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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pycr1
Name: pyrroline-5-carboxylate reductase 1
Acc ID: CHEBI:71957
Term: XL147
Definition: A sulfonamide that is the N-4-toluenesulfonyl (N-tosyl) derivative of N-(2,1,3-benzothiadiazol-5-yl)quinoxaline-2,3-diamine. A selective PI3K inhibitor used in cancer treatment.
Chemical ID: MESH:C581157
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pycr1multiple interactionsISOPycr1 (Mus musculus)6480464CTD[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PYCR1 mRNA; XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PYCR1 mRNA]PMID:27935865 PMID:29891994
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