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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307261
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsdmd
Name: gasdermin D
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsdmdmultiple interactionsISOGsdmd (Mus musculus)6480464CTDandrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased cleavage of GSDMD protein]PMID:37987454
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