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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307189
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb2
Name: nuclear factor kappa B subunit 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb2affects expressionEXP 6480464CTDOzone affects the expression of NFKB2 mRNAPMID:35112007
Nfkb2increases expressionISONFKB2 (Homo sapiens)6480464CTDOzone results in increased expression of NFKB2 mRNAPMID:31476115
Nfkb2multiple interactionsISONFKB2 (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which affects the expression of NFKB2 mRNA; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of NFKB2 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of NFKB2 mRNA; Aripiprazole promotes the reaction [Ozone results in increased expression of NFKB2 mRNA]PMID:31476115 PMID:32992648 PMID:35430440
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