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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307189
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb2
Name: nuclear factor kappa B subunit 2
Acc ID: CHEBI:192710
Term: SM-164
Definition: A potent cell-permeable and bivalent Smac mimetic which binds to XIAP, cIAP-1 and cIAP-2 proteins (Ki = 0.56 nM, 0.31 nM and 1.1 nM, respectively). It induces apoptosis and tumor regression in cancer xenograft models.
Chemical ID: MESH:C533467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb2increases metabolic processingISONFKB2 (Homo sapiens)6480464CTDSM 164 results in increased metabolism of NFKB2 proteinPMID:22241084
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