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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306919
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sumo1
Name: small ubiquitin-like modifier 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sumo1affects localizationISOSUMO1 (Homo sapiens)6480464CTDTretinoin affects the localization of SUMO1 proteinPMID:9834237
Sumo1decreases expressionISOSUMO1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of SUMO1 mRNA; Tretinoin results in decreased expression of SUMO1 protein; Tretinoin results in decreased expression of SUMO1 protein modified formPMID:17218384 PMID:24819975
Sumo1increases expressionISOSUMO1 (Homo sapiens)6480464CTDTretinoin results in increased expression of SUMO1 mRNAPMID:10673743
Sumo1multiple interactionsISOSUMO1 (Homo sapiens)6480464CTDarsenic trioxide promotes the reaction [Tretinoin results in increased expression of SUMO1 mRNA]; SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]; SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of EGR1 mRNA]; SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of PXN mRNA]; SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]PMID:10673743 PMID:24819975
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