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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Traf6
Name: TNF receptor associated factor 6
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Traf6decreases response to substanceISOTRAF6 (Homo sapiens)6480464CTDTRAF6 mRNA results in decreased susceptibility to CamptothecinPMID:25269479
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