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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306693
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bach1
Name: BTB domain and CNC homolog 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bach1multiple interactionsISOBACH1 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NDUFB8 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SDHB protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of UQCRC2 protein]; BACH1 gene mutant form results in decreased susceptibility to [lead acetate results in increased abundance of Lead]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein]PMID:36096218
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