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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306585
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrrc8c
Name: leucine rich repeat containing 8 VRAC subunit C
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrrc8caffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of LRRC8C mRNAPMID:22298810 PMID:34747641
Lrrc8cincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LRRC8C mRNAPMID:32109520
Lrrc8caffects expressionISOLrrc8c (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of LRRC8C mRNAPMID:21570461 PMID:26377647
Lrrc8cincreases expressionISOLrrc8c (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LRRC8C mRNAPMID:21889950 PMID:25975270
Lrrc8cmultiple interactionsISOLrrc8c (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRRC8C promoter]PMID:19654925
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