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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1decreases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of PINK1 proteinPMID:24475098
Pink1affects response to substanceISOPINK1 (Homo sapiens)6480464CTDPINK1 protein affects the susceptibility to 1-Methyl-4-phenylpyridiniumPMID:16226715
Pink1increases expressionISOPINK1 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PINK1 proteinPMID:36078115
Pink1increases response to substanceISOPINK1 (Homo sapiens)6480464CTDPINK1 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridiniumPMID:20547144
Pink1multiple interactionsISOPINK1 (Homo sapiens)6480464CTDPINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; PINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]PMID:21366594
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