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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of PINK1 mRNA; Carbon Tetrachloride results in decreased expression of PINK1 proteinPMID:26882442 PMID:31150632
Pink1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 mRNA]PMID:26882442 PMID:31150632
Pink1increases expressionISOPink1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of PINK1 proteinPMID:35405287
Pink1multiple interactionsISOPink1 (Mus musculus)6480464CTDSirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of PINK1 protein]PMID:35405287
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