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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sh3tc1affects methylationISOSH3TC1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SH3TC1 5' UTR; Benzo(a)pyrene affects the methylation of SH3TC1 intronPMID:27901495 PMID:30157460
Sh3tc1decreases expressionISOSh3tc1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SH3TC1 mRNAPMID:21569818
Sh3tc1decreases methylationISOSH3TC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SH3TC1 exon; Benzo(a)pyrene results in decreased methylation of SH3TC1 promoterPMID:27901495
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