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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf6
Name: activating transcription factor 6
Acc ID: CHEBI:63952
Term: arsenic trichloride
Definition: A arsenic molecular entity that consists of a single arsenic atom bearing three chloro substituents.
Chemical ID: MESH:C050510
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf6multiple interactionsISOATF6 (Homo sapiens)6480464CTD[arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6 promoter]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of ATF6 protein; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA]PMID:35625704
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