GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppm1d | decreases expression | EXP | | 6480464 | CTD | Manganese results in decreased expression of PPM1D protein | PMID:25791630 | Ppm1d | multiple interactions | EXP | | 6480464 | CTD | [Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein] | PMID:25791630 | | ||||||||||||||||||||||
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