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GENE - TERM ANNOTATION REPORT

RGD ID: 1304979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Usp8
Name: ubiquitin specific peptidase 8
Acc ID: DOID:3946
Term: pituitary-dependent Cushing's disease
Definition: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Definition Source(s): MESH:D047748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Usp8 ISOUSP8 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:25485838
Usp8 ISOUSP8 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Pituitary dependent hypercortisolismPMID:25675982 PMID:25741868 PMID:25942478 PMID:28492532
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