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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304625
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k6affects expressionISOMAP3K6 (Homo sapiens)6480464CTDCisplatin affects the expression of MAP3K6 mRNAPMID:23300844
Map3k6multiple interactionsISOMAP3K6 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of MAP3K6 mRNAPMID:27392435
Map3k6multiple interactionsISOMap3k6 (Mus musculus)6480464CTD[Cisplatin co-treated with RELB mutant form] results in decreased expression of MAP3K6 mRNAPMID:23625948
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