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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo2
Name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo2affects activityISONQO2 (Homo sapiens)6480464CTDMelatonin affects the activity of NQO2 proteinPMID:22289031
Nqo2multiple interactionsISONQO2 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]PMID:20399199
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