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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3bdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of DNMT3B mRNA; Cadmium Chloride results in decreased expression of DNMT3B proteinPMID:33865896
Dnmt3bincreases expressionISODnmt3b (Mus musculus)6480464CTDCadmium Chloride results in increased expression of DNMT3B proteinPMID:27984135
Dnmt3bincreases expressionISODNMT3B (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of DNMT3B mRNA; Cadmium Chloride results in increased expression of DNMT3B proteinPMID:17938735 PMID:25448810 PMID:34520792
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