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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Clic1
Name: chloride intracellular channel 1
Acc ID: CHEBI:31653
Term: glafenine
Definition: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Chemical ID: MESH:D005897
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Clic1increases expressionEXP 6480464CTDGlafenine results in increased expression of CLIC1 mRNAPMID:24136188
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