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GENE - TERM ANNOTATION REPORT

RGD ID: 12255827
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: RAPGEF3
Name: Rap guanine nucleotide exchange factor 3
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RAPGEF3enablesIEAUniProtKB:O95398 or UniProtKB:Q8VCC8 or ensembl:ENSMUSP00000116426 or ensembl:ENSP00000395708150520179Ensembl GO_REF:0000107
RAPGEF3enablesIEAInterPro:IPR001895 or InterPro:IPR008937 or InterPro:IPR019804 or InterPro:IPR036964150520179InterPro GO_REF:0000002
RAPGEF3enablesIEAPANTHER:PTHR23113:SF24150520179TreeGrafter GO_REF:0000118
RAPGEF3enablesIEAUniProtKB-KW:KW-0344150520179UniProt GO_REF:0000043
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