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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12096923
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: VPS41
Name: VPS41 subunit of HOPS complex
Acc ID: CHEBI:197437
Term: mocetinostat
Definition: A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).
Chemical ID: MESH:C523184
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VPS41decreases expressionEXP 6480464CTDmocetinostat results in decreased expression of VPS41 mRNAPMID:27255383
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