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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11414885
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hoxa1
Name: homeobox A1
Acc ID: CHEBI:90441
Term: WIN 18446
Definition: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish.
Chemical ID: MESH:C002491
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hoxa1multiple interactionsISOHoxa1 (Mus musculus)6480464CTDN,N'-bis(dichloroacetyl)-1,8-octamethylenediamine inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]PMID:23696197
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