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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:36386
Term: dichloroacetic acid
Definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
Chemical ID: MESH:D003999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases methylationEXP 6480464CTDDichloroacetic Acid results in decreased methylation of MYC gene; Dichloroacetic Acid results in decreased methylation of MYC promoterPMID:10774822 PMID:11284051 PMID:11532874 PMID:16014735
Mycincreases expressionEXP 6480464CTDDichloroacetic Acid results in increased expression of MYC mRNA; Dichloroacetic Acid results in increased expression of MYC proteinPMID:10774822 PMID:11532874 PMID:28962523
Mycmultiple interactionsEXP 6480464CTD[Dichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]; Methionine inhibits the reaction [[Dichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA]; Methionine inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC protein]PMID:10774822 PMID:11532874 PMID:16014735
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