Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10869
Species: Mus musculus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhbaffects expressionEXP 6480464CTDbisphenol A affects the expression of LHB mRNAPMID:22875908
Lhbdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LHB proteinPMID:32407858 PMID:38021376
Lhbincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LHB mRNA; bisphenol A results in increased expression of LHB proteinPMID:24532816 PMID:38440074
Lhbincreases secretionEXP 6480464CTDbisphenol A results in increased secretion of LHB proteinPMID:32488702
Lhbmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased secretion of LHB protein; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased secretion of LHB protein]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of LHB mRNA]; KISS1 protein inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; KISS1R protein promotes the reaction [bisphenol A results in increased expression of LHB mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of CPLX1 mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of EVX2 mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of GGN mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of MARCKS mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of MS4A6C mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of POC1B mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of PPP1R3A mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of SASS6 mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of TPX2 mRNA]; LHB protein affects the reaction [bisphenol A results in decreased expression of WDR19 mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of ATP6V1E2 mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of BBS4 mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of CYP7A1 mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of JRK mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of KLHL18 mRNA]; LHB protein affects the reaction [bisphenol A results in increased expression of PEX2 mRNA]PMID:17706920 PMID:24532816 PMID:32407858 PMID:32488702 PMID:37364641
Lhbaffects expressionISOLHB (Homo sapiens)6480464CTDbisphenol A affects the expression of LHBPMID:26021997
Lhbdecreases activityISOLHB (Homo sapiens)6480464CTDbisphenol A results in decreased activity of LHB proteinPMID:31212720
Lhbdecreases expressionISOLhb (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of LHB mRNA; bisphenol A results in decreased expression of LHB proteinPMID:14605012 PMID:19479018 PMID:19782717 PMID:19837096 PMID:20144698 PMID:25181051 PMID:27539358 PMID:31063457 PMID:31424294 PMID:35465754 PMID:36864339 PMID:38513920
Lhbdecreases secretionISOLhb (Rattus norvegicus)6480464CTDbisphenol A results in decreased secretion of LHB proteinPMID:25575453
Lhbincreases expressionISOLhb (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of LHB mRNA; bisphenol A results in increased expression of LHB proteinPMID:21303948 PMID:25575453 PMID:27296223 PMID:28641706 PMID:31697385
Lhbincreases expressionISOLHB (Homo sapiens)6480464CTDbisphenol A results in increased expression of LHB proteinPMID:24786630
Lhbincreases secretionISOLhb (Rattus norvegicus)6480464CTDbisphenol A results in increased secretion of LHB proteinPMID:30228064 PMID:31129395
Lhbmultiple interactionsISOLhb (Rattus norvegicus)6480464CTD4-nonylphenol inhibits the reaction [bisphenol A results in increased secretion of LHB protein]; [bisphenol A co-treated with tributyltin] results in increased secretion of LHB protein; bisphenol A inhibits the reaction [4-nonylphenol results in increased secretion of LHB protein]; bisphenol A inhibits the reaction [Estradiol results in increased secretion of LHB protein]; bisphenol A inhibits the reaction [GNRH1 protein results in increased expression of LHB protein]; bisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]; Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; p-271 peptide inhibits the reaction [bisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]]; p-coumaric acid inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]PMID:19479018 PMID:20951796 PMID:21303948 PMID:30228064 PMID:31129395 PMID:35465754 PMID:38513920
Go Back to source page   Continue to Ontology report