GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jun | decreases expression | EXP | | 6480464 | CTD | pyrazolanthrone results in decreased expression of JUN protein | PMID:18593901 | Jun | decreases phosphorylation | EXP | | 6480464 | CTD | pyrazolanthrone results in decreased phosphorylation of JUN protein | PMID:25237887 | Jun | multiple interactions | EXP | | 6480464 | CTD | pyrazolanthrone inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [monobutyl phthalate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein] | PMID:12774022 PMID:16166651 PMID:16322078 PMID:17460151 PMID:19768117 PMID:23103562 PMID:26209791 PMID:28697429 PMID:30768131 PMID:32738922 | Jun | decreases activity | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | pyrazolanthrone results in decreased activity of JUN protein | PMID:15196213 | Jun | decreases phosphorylation | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | pyrazolanthrone results in decreased phosphorylation of JUN protein | PMID:17950587 | Jun | decreases phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | pyrazolanthrone results in decreased phosphorylation of JUN protein | PMID:15034932 PMID:15850772 PMID:16061660 PMID:16932349 PMID:20148354 PMID:30709899 | Jun | increases degradation | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | pyrazolanthrone results in increased degradation of JUN protein | PMID:12169099 | Jun | multiple interactions | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | [cypermethrin co-treated with pyrazolanthrone] results in decreased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Amphetamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [cypermethrin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Indolinone A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Patulin results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]] | PMID:15194466 PMID:15252869 PMID:15342272 PMID:15838870 PMID:16337876 PMID:18021293 PMID:19002563 PMID:19225867 PMID:19418558 PMID:24111524 PMID:28087833 PMID:28474156 PMID:34794910 PMID:34896196 PMID:35172196 PMID:35512476 | Jun | multiple interactions | ISO | JUN (Homo sapiens) | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]; [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein]; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [Estradiol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Leflunomide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Methyl Methanesulfonate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Quercetin affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA] | PMID:12393500 PMID:12663670 PMID:12832416 PMID:15019843 PMID:15028728 PMID:15322261 PMID:15677771 PMID:15923621 PMID:15930183 PMID:16041517 PMID:16061660 PMID:16357177 PMID:16407847 PMID:16872482 PMID:17125918 PMID:18633430 PMID:18982426 PMID:19292871 PMID:19812349 PMID:20148354 PMID:20301194 PMID:20338993 PMID:20632440 PMID:21062976 PMID:21165570 PMID:21911303 PMID:22003962 PMID:22020770 PMID:22166487 PMID:22288910 PMID:23082001 PMID:23219847 PMID:23791922 PMID:23836369 PMID:24469321 PMID:24967690 PMID:25200491 PMID:26514923 PMID:26630137 PMID:28474156 PMID:28988120 PMID:30133131 PMID:30261343 PMID:30709899 PMID:33677747 PMID:33959992 PMID:35689653 | | ||||||||||||||||||||||
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