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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812
Species: Mus musculus
RGD Object: Gene
Symbol: Ins2
Name: insulin II
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2multiple interactionsEXP 6480464CTD[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the susceptibility to Ethanol] which results in increased secretion of CCL2 protein; [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the susceptibility to Ethanol] which results in increased secretion of IL6 protein; [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the susceptibility to Ethanol; Ethanol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; Ethanol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased secretion of ADIPOQ protein]PMID:32171850
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