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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10700
Species: Mus musculus
RGD Object: Gene
Symbol: Gstt1
Name: glutathione S-transferase, theta 1
Acc ID: CHEBI:165887
Term: N-acetyl-S-phenyl-L-cysteine
Definition: The S-phenyl derivative of N-acetyl-L-cysteine. It is a urinary metabolite of benzene and used as a biomarker to assess benzene exposure.
Chemical ID: MESH:C053003
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstt1affects abundanceISOGSTT1 (Homo sapiens)6480464CTDGSTT1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine; GSTT1 polymorphism affects the abundance of S-phenyl-N-acetylcysteinePMID:20100551 PMID:21300142
Gstt1affects chemical synthesisISOGSTT1 (Homo sapiens)6480464CTDGSTT1 protein polymorphism affects the chemical synthesis of S-phenyl-N-acetylcysteinePMID:15533900 PMID:15935803
Gstt1multiple interactionsISOGSTT1 (Homo sapiens)6480464CTD[GSTT1 gene SNP affects the metabolism of Benzene] which affects the abundance of S-phenyl-N-acetylcysteine; GSTT1 gene polymorphism affects the reaction [GSTM1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine]PMID:20100551 PMID:30086327
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