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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10594
Species: Mus musculus
RGD Object: Gene
Symbol: Fn1
Name: fibronectin 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fn1decreases expressionISOFn1 (Rattus norvegicus)6480464CTDRotenone results in decreased expression of FN1 mRNAPMID:28374803
Fn1decreases expressionISOFN1 (Homo sapiens)6480464CTDRotenone results in decreased expression of FN1 mRNAPMID:17651460
Fn1decreases secretionISOFN1 (Homo sapiens)6480464CTDRotenone results in decreased secretion of FN1 proteinPMID:17651460
Fn1multiple interactionsISOFN1 (Homo sapiens)6480464CTDRotenone inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]; Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]; Rotenone inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]; Rotenone inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein]; Rotenone inhibits the reaction [Glucose results in increased secretion of FN1 protein]PMID:15086456 PMID:17395008
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