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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10550
Species: Mus musculus
RGD Object: Gene
Symbol: Esd
Name: esterase D/formylglutathione hydrolase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esdincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ESD mRNAPMID:14625279 PMID:15034205 PMID:15894712 PMID:19770486 PMID:21569818 PMID:22228805 PMID:25908611
Esdmultiple interactionsEXP 6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ESD mRNA; [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ESD mRNA]PMID:14625279 PMID:15894712
Esdaffects methylationISOESD (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ESD promoterPMID:27901495
Esdincreases methylationISOESD (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ESD 5' UTRPMID:27901495
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