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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10430
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b2decreases activityISOCYP11B2 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP11B2 proteinPMID:15743198
Cyp11b2increases expressionISOCYP11B2 (Homo sapiens)6480464CTDKetoconazole results in increased expression of CYP11B2 mRNAPMID:16935330
Cyp11b2multiple interactionsISOCYP11B2 (Homo sapiens)6480464CTDKetoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]PMID:16935330 PMID:31982514
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