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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10370
Species: Mus musculus
RGD Object: Gene
Symbol: Cnr1
Name: cannabinoid receptor 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cnr1multiple interactionsEXP 6480464CTDCycloheximide results in decreased expression of and affects the localization of CNR1 proteinPMID:27513693
Cnr1multiple interactionsISOCNR1 (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]PMID:17041005 PMID:22258905
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