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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10246
Species: Mus musculus
RGD Object: Gene
Symbol: Brca1
Name: breast cancer 1, early onset
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]PMID:16489025 PMID:18259752
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