SD |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
24.0 |
% |
5.8 |
10.05 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106117 |
3028 |
SD |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
26.3 |
% |
5.7 |
9.87 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106118 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
88.0 |
% |
29.7 |
51.44 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106126 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
42 days-56 days |
3 |
10.3 |
% |
1.1 |
1.91 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106146 |
3028 |
SD |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
0.96 |
% |
0.05 |
0.08 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106155 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
1.83 |
% |
0.07 |
0.12 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106163 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
14.0 |
% |
7.3 |
12.64 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106162 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
55.9 |
% |
13.2 |
22.86 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106144 |
3028 |
SD |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and vehicle control condition (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
0.99 |
% |
0.35 |
0.61 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106153 |
3028 |
SD-Abcb1aem1Sage-/- |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
42 days-56 days |
3 |
1.68 |
% |
0.07 |
0.12 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106164 |
3028 |
SD-Abcb1aem1Sage-/- |
aqueous humor uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
42 days-56 days |
3 |
11.0 |
% |
0.5 |
0.87 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106145 |
3028 |
SD |
brain uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
blood-brain barrier morphology trait |
male |
35 days-49 days |
3 |
1.18 |
% |
0.2 |
0.35 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106154 |
3028 |
SD |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
35 days-49 days |
3 |
27.9 |
% |
5.7 |
9.87 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106119 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
18.8 |
% |
3.1 |
5.37 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106127 |
3028 |
SD-Abcb1aem1Sage-/- |
retinal uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
retina blood vessel morphology trait |
male |
42 days-56 days |
3 |
27.0 |
% |
3.2 |
5.54 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106128 |
3028 |
SD |
aqueous humor uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and digoxin (0.01 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
15.8 |
% |
3.5 |
6.06 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106136 |
3028 |
SD |
aqueous humor uptake index of digoxin |
tritiated digoxin (10 uCi) (for 0 hours) and verapamil (3 mmol/l) (for 0 hours) |
Fujii S, et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819. |
aqueous humor morphology trait |
male |
35 days-49 days |
3 |
9.48 |
% |
0.55 |
0.95 |
liquid scintillation counting |
0.0 |
carotid injection |
15 |
sec post excision |
digoxin uptake index |
106137 |
3028 |