| SD |
serum creatinine level |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
blood creatinine amount |
female |
days
| 12 |
|
0.93 |
mg/dl |
0.05 |
0.17 |
serum creatinine analysis |
0.0 |
unx |
97 |
days |
|
100640 |
2499 |
| SD |
left kidney wet weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
days
| 5 |
|
1.16 |
g |
0.11 |
0.25 |
post excision weight measurement |
0.0 |
unx |
13 |
days |
remnant kidney |
101545 |
2602 |
| SD |
left kidney wet weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
days
| 5 |
|
1.49 |
g |
0.1 |
0.23 |
post excision weight measurement |
0.0 |
unx |
13 |
days |
remnant kidney |
101546 |
2602 |
| SD |
plasma renin activity level |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
renin activity |
male |
days
| 5 |
|
13.3 |
ng/ml/h |
5.5 |
12.3 |
radioimmunoassay |
0.0 |
unx |
13 |
days |
|
101565 |
2602 |
| SD |
systolic blood pressure |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
arterial blood pressure trait |
male |
days
| 7 |
undefined |
109.0 |
mmHg |
4.16 |
11.0 |
tail cuff plethysmography |
0.0 |
unx |
28 |
days |
|
101585 |
2602 |
| SD |
systolic blood pressure |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
arterial blood pressure trait |
male |
days
| 6 |
undefined |
186.0 |
mmHg |
10.61 |
26.0 |
tail cuff plethysmography |
0.0 |
unx |
28 |
days |
|
101586 |
2602 |
| SD |
heart wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
days
| 7 |
|
0.88 |
g |
0.04 |
0.11 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
|
101589 |
2602 |
| SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
days
| 7 |
|
57.0 |
mg |
1.51 |
4.0 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
|
101601 |
2602 |
| SD |
serum creatinine level |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
blood creatinine amount |
female |
days
| 12 |
|
0.93 |
mg/dl |
0.02 |
0.07 |
serum creatinine analysis |
0.0 |
unx |
97 |
days |
|
100638 |
2499 |
| SD |
body weight |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
body mass |
female |
days
| 12 |
|
290.6 |
g |
6.8 |
23.56 |
body weighing method |
0.0 |
unx |
97 |
days |
|
100635 |
2499 |
| SD |
creatinine clearance |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
glomerular filtration trait |
female |
days
| 12 |
|
0.56 |
ml/min |
0.03 |
0.1 |
serum creatinine analysis |
0.0 |
unx |
97 |
days |
|
100643 |
2499 |
| SD |
serum parathyroid hormone level |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
blood parathyroid hormone amount |
female |
days
| 12 |
|
371.0 |
pg/ml |
100.0 |
346.41 |
serum parathyroid hormone analysis |
0.0 |
unx |
97 |
days |
|
100648 |
2499 |
| SD |
body weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 5 |
|
285.0 |
g |
6.71 |
15.0 |
body weighing method |
0.0 |
unx |
13 |
days |
|
101537 |
2602 |
| SD |
change in body weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 5 |
|
66.0 |
g |
4.92 |
11.0 |
body weighing method |
0.0 |
unx |
13 |
days |
change from surgery weight |
101542 |
2602 |
| SD |
urine total protein excretion rate |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
total urine protein amount |
male |
days
| 5 |
|
31.0 |
mg/d |
5.37 |
12.0 |
urine protein analysis |
0.0 |
unx |
13 |
days |
|
101553 |
2602 |
| SD |
plasma aldosterone level |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
blood aldosterone amount |
male |
days
| 5 |
|
181.0 |
pg/ml |
55.45 |
124.0 |
plasma aldosterone analysis |
0.0 |
unx |
13 |
days |
|
101557 |
2602 |
| SD |
plasma renin activity level |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
renin activity |
male |
days
| 5 |
|
5.2 |
ng/ml/h |
2.24 |
5.0 |
radioimmunoassay |
0.0 |
unx |
13 |
days |
|
101566 |
2602 |
| SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
days
| 7 |
|
1.47 |
g |
0.07 |
0.18 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
remnant kidney |
101581 |
2602 |
| SD |
plasma potassium level |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
blood potassium amount |
male |
days
| 6 |
|
4.5 |
mmol/l |
0.2 |
0.5 |
ex vivo blood analysis |
0.0 |
unx |
28 |
days |
|
101598 |
2602 |
| SD |
body weight |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
body mass |
female |
days
| 12 |
|
281.9 |
g |
4.2 |
14.55 |
body weighing method |
0.0 |
unx |
97 |
days |
|
100633 |
2499 |
| SD |
body weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 5 |
|
302.0 |
g |
6.26 |
14.0 |
body weighing method |
0.0 |
unx |
13 |
days |
|
101538 |
2602 |
| SD |
systolic blood pressure |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
arterial blood pressure trait |
male |
days
| 5 |
undefined |
125.0 |
mmHg |
6.26 |
14.0 |
tail cuff plethysmography |
0.0 |
unx |
13 |
days |
|
101549 |
2602 |
| SD |
change in body weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 7 |
|
97.0 |
g |
7.56 |
20.0 |
body weighing method |
0.0 |
unx |
28 |
days |
change from surgery weight |
101577 |
2602 |
| SD |
urine total protein excretion rate |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
total urine protein amount |
male |
days
| 6 |
|
217.0 |
mg/d |
28.99 |
71.0 |
urine protein analysis |
0.0 |
unx |
28 |
days |
|
101594 |
2602 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 6 |
|
25.3 |
% |
4.53 |
11.1 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
28 |
days |
|
101606 |
2602 |
| SD |
creatinine clearance |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
glomerular filtration trait |
female |
days
| 12 |
|
0.58 |
ml/min |
0.05 |
0.17 |
serum creatinine analysis |
0.0 |
unx |
97 |
days |
|
100645 |
2499 |
| SD |
adrenal gland weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
days
| 5 |
|
56.0 |
mg |
1.79 |
4.0 |
post excision weight measurement |
0.0 |
unx |
13 |
days |
|
101561 |
2602 |
| SD |
adrenal gland weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
days
| 5 |
|
60.0 |
mg |
3.13 |
7.0 |
post excision weight measurement |
0.0 |
unx |
13 |
days |
|
101562 |
2602 |
| SD |
adrenal gland weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
adrenal gland mass |
male |
days
| 6 |
|
60.0 |
mg |
3.27 |
8.0 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
|
101602 |
2602 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 7 |
|
4.7 |
% |
1.97 |
5.2 |
ex vivo light microscopy with histochemistry |
0.0 |
unx |
28 |
days |
|
101605 |
2602 |
| SD |
serum parathyroid hormone level |
controlled calcium content diet (0.6 %) (for 97 days) and controlled content diet (0.9 %) (for 97 days) and unilateral nephrectomy (for 97 days) then paricalcitol (0.8 mg/kg) (for 90 days) and enalapril (25 mg/l) (for 90 days) |
Finch JL, et al., Am J Physiol Renal Physiol. 2011 Sep 28. |
blood parathyroid hormone amount |
female |
days
| 12 |
|
170.0 |
pg/ml |
60.0 |
207.85 |
serum parathyroid hormone analysis |
0.0 |
unx |
97 |
days |
|
100650 |
2499 |
| SD |
change in body weight |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 5 |
|
74.0 |
g |
7.6 |
17.0 |
body weighing method |
0.0 |
unx |
13 |
days |
change from surgery weight |
101541 |
2602 |
| SD |
systolic blood pressure |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
arterial blood pressure trait |
male |
days
| 5 |
undefined |
149.0 |
mmHg |
9.39 |
21.0 |
tail cuff plethysmography |
0.0 |
unx |
13 |
days |
|
101550 |
2602 |
| SD |
urine total protein excretion rate |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
total urine protein amount |
male |
days
| 5 |
|
87.0 |
mg/d |
12.52 |
28.0 |
urine protein analysis |
0.0 |
unx |
13 |
days |
|
101554 |
2602 |
| SD |
plasma aldosterone level |
unilateral nephrectomy (between 12 and 14 days) then enalapril (50 mg/l) (between 12 and 14 days) and losartan (180 mg/l) (between 12 and 14 days) and aldosterone (30-40 mg/kg/d) (between 12 and 14 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
blood aldosterone amount |
male |
days
| 5 |
|
487.0 |
pg/ml |
50.98 |
114.0 |
plasma aldosterone analysis |
0.0 |
unx |
13 |
days |
|
101558 |
2602 |
| SD |
body weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 7 |
|
307.0 |
g |
36.66 |
25.0 |
body weighing method |
0.0 |
unx |
28 |
days |
|
101573 |
2602 |
| SD |
body weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 6 |
|
312.0 |
g |
9.8 |
24.0 |
body weighing method |
0.0 |
unx |
28 |
days |
|
101574 |
2602 |
| SD |
change in body weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
body mass |
male |
days
| 6 |
|
106.0 |
g |
10.61 |
26.0 |
body weighing method |
0.0 |
unx |
28 |
days |
change from surgery weight |
101578 |
2602 |
| SD |
left kidney wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney mass |
male |
days
| 6 |
|
2.03 |
g |
0.2 |
0.48 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
remnant kidney |
101582 |
2602 |
| SD |
heart wet weight |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
heart mass |
male |
days
| 6 |
|
1.28 |
g |
0.05 |
0.12 |
post excision weight measurement |
0.0 |
unx |
28 |
days |
|
101590 |
2602 |
| SD |
urine total protein excretion rate |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
total urine protein amount |
male |
days
| 7 |
|
30.0 |
mg/d |
5.67 |
15.0 |
urine protein analysis |
0.0 |
unx |
28 |
days |
|
101593 |
2602 |
| SD |
plasma potassium level |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
blood potassium amount |
male |
days
| 7 |
|
6.2 |
mmol/l |
0.15 |
0.4 |
ex vivo blood analysis |
0.0 |
unx |
28 |
days |
|
101597 |
2602 |