| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
15 |
0.03 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56235 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
99.64 |
% |
0.36 |
1.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56305 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
-8.48 |
null |
0.05 |
0.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56018 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
15 |
-8.57 |
null |
0.06 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56023 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
16 |
0.04 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
55734 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
16 |
-8.53 |
null |
0.09 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54608 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
-8.61 |
null |
0.06 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
54613 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
0.04 |
10E-7mol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56230 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
0.03 |
10E-7mol/l |
0.0 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
55739 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
15 |
98.67 |
% |
1.2 |
4.64 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56310 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
16 |
99.44 |
% |
0.44 |
1.75 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56464 |
522 |
| SS.BN-(D12Arb13-D12Rat79)/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
99.57 |
% |
0.31 |
1.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
Moms and pups used in studies were fed Teklad |
56469 |
522 |