Phenominer Database Results (475 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 13.75 mmHg 2.88 6.44 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51737 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 14.06 mmHg 2.07 2.92 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51738 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 36.87 mmHg 3.95 11.85 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51767 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 27.49 mmHg 2.28 9.69 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51769 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 35.87 mmHg 2.98 10.33 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51772 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 16.69 mmHg 3.46 10.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51777 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 16.08 mmHg 3.41 9.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51779 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 22.76 beats/min 15.34 34.3 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51792 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 13.26 mmHg 1.18 2.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51865 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 16.83 mmHg 2.71 7.17 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51870 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 29.83 mmHg 4.13 8.26 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51912 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -26.7 beats/min 9.39 18.78 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51928 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 7.17 beats/min 11.83 33.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51927 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -46.2 beats/min 14.43 38.19 vascular fluid filled catheter 51940 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 12.69 beats/min 16.61 43.95 vascular fluid filled catheter 51938 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 16.58 mmHg 2.37 7.11 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51961 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 19.47 mmHg 4.39 10.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51972 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -0.9 mmHg 3.53 9.35 vascular fluid filled catheter 52026 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -6.25 beats/min 7.6 21.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52059 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -14.34 beats/min 12.39 32.79 vascular fluid filled catheter 52075 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -73.2 beats/min 18.38 55.13 vascular fluid filled catheter 52078 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 11.58 mmHg 5.14 10.28 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50544 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -24.45 beats/min 31.16 62.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50590 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -9.39 beats/min 43.01 96.17 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50594 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -58.76 beats/min 39.1 103.44 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50596 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -52.77 beats/min 23.98 67.84 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50597 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 3.22 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50604 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -1.7 mmHg 1.59 4.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50608 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 83.6 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50679 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 13 17.49 beats/min 12.18 43.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50680 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 20.24 beats/min 10.4 25.47 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50685 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -5.23 beats/min 21.31 56.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50686 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -60.45 beats/min 16.96 50.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50716 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 28.48 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50720 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -5.86 beats/min 17.62 46.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50724 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -12.7 beats/min 20.48 40.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50727 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -37.71 beats/min 15.71 47.14 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50726 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -25.21 beats/min 19.43 54.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50728 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.9 mmHg 2.1 5.56 vascular fluid filled catheter 50771 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 2.19 mmHg 1.66 4.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50772 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 4.89 mmHg 4.16 11.0 vascular fluid filled catheter 50769 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 5.95 mmHg 2.39 9.25 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50774 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 4.84 mmHg 2.48 8.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50779 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -0.7 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50819 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 16.8 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50823 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -31.59 beats/min 11.86 31.37 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50848 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 -1.05 mmHg 1.42 5.31 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50849 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 7.74 mmHg 2.21 5.42 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50858 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -42.8 beats/min 16.6 40.66 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50866 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 4.25 mmHg 0.13 0.18 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50914 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 2.88 mmHg 1.84 5.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50926 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 1.42 mmHg 2.41 7.24 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50925 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 3.68 mmHg 1.76 3.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50928 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 1.04 mmHg 1.37 4.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50932 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 7.36 mmHg 1.31 3.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50959 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 4.14 mmHg 2.16 4.83 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50992 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.59 mmHg 3.89 7.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50991 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -47.6 beats/min 15.76 47.28 vascular fluid filled catheter 51040 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -1.22 mmHg 1.22 2.99 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51080 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 1.42 mmHg 1.42 2.0 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51083 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 8.89 mmHg 2.26 9.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51101 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 16.96 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51103 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 0.45 mmHg 3.08 9.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51109 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 15.03 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51128 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 -1.56 mmHg 2.17 8.42 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51132 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 0.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51232 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -22.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51235 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -22.66 beats/min 17.34 45.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51239 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -1.39 beats/min 7.41 20.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51240 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -15.3 beats/min 12.74 54.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51368 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 12 -17.82 beats/min 8.09 28.03 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51371 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -14.77 beats/min 11.54 39.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51373 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -37.73 beats/min 10.68 26.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51375 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 10.88 beats/min 4.58 12.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51378 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 20.44 mmHg 5.29 11.82 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51490 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -4.71 mmHg 2.19 6.57 vascular fluid filled catheter 51624 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 30.91 mmHg 4.23 11.18 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51665 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -20.24 beats/min 14.12 31.57 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50337 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -57.41 beats/min 0.99 1.4 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50338 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -51.54 beats/min 9.58 23.46 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50343 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -21.75 beats/min 16.71 64.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50355 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.88 beats/min 7.63 18.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50364 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 -0.61 mmHg 2.07 4.64 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50432 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.02 mmHg 7.38 14.75 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50431 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 12 37.32 beats/min 16.66 57.7 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50507 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -0.13 beats/min 12.28 42.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50509 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 23.0 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50508 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 43.14 beats/min 20.88 55.24 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50510 481
GH/Omr kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 1.22 g 0.01 0.05 post excision weight measurement ng/kg/min 11525 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 16 1.17 g 0.06 0.23 post excision weight measurement 0.0 ng/kg/min 68331 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 19 1.13 g 0.03 0.15 post excision weight measurement 0.0 ng/kg/min 68330 101
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 128.6 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69537 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 135.6 mmHg 3.2 14.31 vascular indwelling catheter method left femoral artery 120.0 69539 151
LL/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 350.0 days 7 119.0 mmHg 7.0 18.52 vascular fluid filled catheter 0.0 104576 2970
LH/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 350.0 days 7 5.8 ml/min/g 0.3 0.79 ultrasonic flowmeter 0.0 104581 2970
LL/Mav glomerular filtration rate to kidney weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112.0 days 6 1.25 ml/min/g 0.07 0.17 ultrasonic flowmeter 0.0 104610 2970
LH/Mav urine sodium excretion rate to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine sodium amount male 112.0 days 8 0.79 uEq/min/g 0.18 0.51 urine sodium analysis 0.0 104617 2970
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 14.83 mmHg 6.29 12.58 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51736 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 31.28 mmHg 4.3 10.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51776 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.69 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51773 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 30.33 mmHg 2.51 5.03 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51778 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 15.53 beats/min 17.94 50.74 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51795 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 21.98 mmHg 3.61 10.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51862 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.77 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51868 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 21.65 mmHg 1.26 2.52 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51910 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -0.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51919 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -7.24 beats/min 8.54 33.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51920 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -30.53 beats/min 12.42 30.42 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51924 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -30.67 beats/min 12.69 49.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51925 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 21.3 beats/min 54.9 77.64 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51921 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.28 beats/min 7.95 19.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51929 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -5.13 beats/min 19.47 58.41 vascular fluid filled catheter 51939 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 4.62 mmHg 5.89 8.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51964 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -0.9 mmHg 1.72 4.22 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51967 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 25.27 mmHg 3.22 12.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51966 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 13.53 mmHg 3.99 10.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51969 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 7.06 mmHg 2.33 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51970 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 1.21 mmHg 4.28 11.33 vascular fluid filled catheter 52024 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -37.49 beats/min 6.24 18.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52047 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -28.65 beats/min 9.43 39.99 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52049 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 12 -22.97 beats/min 15.42 53.41 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52052 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 75.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52053 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.07 beats/min 14.76 36.15 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52056 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -65.74 beats/min 24.24 72.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52057 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -6.75 beats/min 8.96 17.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52058 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -33.41 beats/min 13.0 39.01 vascular fluid filled catheter 52074 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -14.49 beats/min 8.94 23.64 vascular fluid filled catheter 52079 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 32.45 beats/min 10.27 29.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50514 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 3.84 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50545 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -47.6 beats/min 14.39 35.25 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50592 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -47.96 beats/min 18.32 51.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50589 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -30.56 beats/min 50.56 101.11 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50593 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 2.83 mmHg 1.4 4.19 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50598 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 2.63 mmHg 2.19 4.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50609 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 0.93 mmHg 2.33 6.16 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50780 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.65 mmHg 0.84 1.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50782 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 14 16.67 beats/min 10.47 39.18 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50791 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 14 2.72 beats/min 8.95 33.48 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50824 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 61.4 beats/min 12.22 29.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50821 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 0.02 mmHg 3.23 8.55 vascular fluid filled catheter 50831 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 14.15 mmHg 3.96 11.89 vascular fluid filled catheter 50828 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 14 -24.64 beats/min 8.37 31.31 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50847 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -1.91 mmHg 0.73 1.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50850 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 16.23 mmHg 3.7 7.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50859 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -48.95 beats/min 23.61 47.22 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50865 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 37.0 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50868 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 10.04 mmHg 1.85 7.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50913 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 8.16 mmHg 3.34 10.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50911 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 10.49 mmHg 2.42 9.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50916 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 6.66 mmHg 2.3 7.96 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50918 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 4.68 mmHg 2.12 5.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50920 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 13.28 mmHg 2.14 8.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50958 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 14 -49.54 beats/min 10.68 39.97 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50974 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -15.18 beats/min 19.55 58.66 vascular fluid filled catheter 51042 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 0.65 mmHg 2.07 5.48 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51084 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 0.1 mmHg 1.74 4.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51136 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.88 mmHg 3.75 7.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51137 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 10.55 beats/min 16.42 63.61 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51233 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -21.84 beats/min 4.82 18.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51236 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 2.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51372 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.21 mmHg 3.42 9.04 vascular fluid filled catheter 51395 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -1.66 mmHg 4.53 11.99 vascular fluid filled catheter 51397 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -31.0 beats/min 19.2 50.79 vascular fluid filled catheter 51414 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 33.19 mmHg 3.65 5.16 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51491 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 28.44 mmHg 4.62 11.33 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51488 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 14 -22.14 beats/min 6.77 25.31 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51614 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -1.38 mmHg 1.79 4.73 vascular fluid filled catheter 51623 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -1.31 mmHg 3.14 9.41 vascular fluid filled catheter 51622 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 25.88 mmHg 1.67 2.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51660 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 32.43 mmHg 3.05 11.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51659 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 28.46 mmHg 1.34 5.03 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51664 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 21.07 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51661 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 23.04 mmHg 2.89 8.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51666 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 3.31 mmHg 1.5 5.62 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50341 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -40.59 beats/min 39.51 88.34 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50345 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 8.0 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50354 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -47.44 beats/min 16.66 49.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50353 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -46.72 beats/min 12.48 48.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50360 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -23.6 beats/min 13.04 31.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50359 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -53.43 beats/min 9.22 35.73 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50358 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -34.84 beats/min 18.09 51.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50362 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 12.31 mmHg 3.92 7.83 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50385 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -10.18 beats/min 11.58 32.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50418 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -35.02 beats/min 11.98 50.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50419 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -57.2 beats/min 18.02 40.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50420 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 12 -34.09 beats/min 18.25 63.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50422 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -47.58 beats/min 14.04 48.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50424 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -8.48 beats/min 15.29 43.23 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50429 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 0.44 mmHg 2.74 7.75 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50435 481
BN.GH-(D2Rat22-D2Mgh11)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 19 1.15 g 0.03 0.15 post excision weight measurement ng/kg/min 11532 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132.0 days-146.0 days 16 299.9 g 6.0 24.0 body weighing method 11541 101
GH/Omr heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 1.69 g 0.03 0.13 post excision weight measurement 0.0 ng/kg/min 68329 101
BN/Elh heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 3.7 mg/g 0.13 0.6 post excision weight measurement 0.0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68338 101
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 69535 151
LL/Mav mean arterial blood pressure bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 35.0 days 9 86.0 mmHg 3.0 9.0 vascular fluid filled catheter 0.0 104572 2970
LL/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112.0 days 6 111.0 mmHg 3.0 7.35 vascular fluid filled catheter 0.0 104574 2970
LL/Mav glomerular filtration rate to kidney weight ratio bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 35.0 days 9 1.01 ml/min/g 0.07 0.21 ultrasonic flowmeter 0.0 104590 2970
LL/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112.0 days 6 1.25 ml/min/g 0.07 0.17 ultrasonic flowmeter 0.0 104592 2970
LL/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 350.0 days 7 1.18 ml/min/g 0.25 0.66 ultrasonic flowmeter 0.0 104594 2970
LH/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112.0 days 8 0.99 ml/min/g 0.08 0.23 ultrasonic flowmeter 0.0 104591 2970
LH/Mav renal blood flow rate right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112.0 days 8 8.7 ml/min/g 0.6 1.7 ultrasonic flowmeter 0.0 104601 2970
LL/Mav mean arterial blood pressure right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112.0 days 6 111.0 mmHg 3.0 7.35 vascular fluid filled catheter 0.0 104598 2970
BN/Elh change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132.0 days-146.0 days 14 -2.28 (beats/min)/(ug/kg) 0.07 0.26 vascular indwelling catheter method 0.0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138470 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132.0 days-146.0 days 11 -1.25 (beats/min)/(ug/kg) 0.05 0.17 vascular indwelling catheter method 0.0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138469 101
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 39.0 mmHg 6.0 21.63 vascular indwelling catheter method left femoral artery 0.0 67302 151
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 15.64 mmHg 2.38 5.84 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51735 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 22.54 mmHg 3.92 10.38 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51739 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 24.22 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51771 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 29.89 mmHg 2.83 9.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51774 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 14.65 beats/min 53.53 107.05 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51791 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 24.92 mmHg 2.29 8.57 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51860 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 3.0 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51866 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 6.46 mmHg 2.32 6.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51863 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 18.85 mmHg 1.94 8.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51864 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 7.1 mmHg 2.79 8.38 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51872 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 14.07 mmHg 1.28 3.13 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51911 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -16.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51922 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.94 mmHg 2.68 5.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51971 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -11.05 beats/min 21.23 60.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52048 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -25.42 beats/min 8.98 26.95 vascular fluid filled catheter 52076 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 2.86 beats/min 18.13 47.96 vascular fluid filled catheter 52077 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 3.0 mmHg 3.86 7.72 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50542 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 1.97 mmHg 2.32 5.68 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50543 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 13.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50584 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -93.61 beats/min 7.41 10.48 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50595 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.56 mmHg 1.17 3.31 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50599 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 2.06 mmHg 2.57 10.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50600 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 1.29 mmHg 2.0 4.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50607 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 3.46 mmHg 3.06 10.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50605 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.7 mmHg 0.63 1.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50610 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 34.55 beats/min 25.93 51.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50688 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -26.53 beats/min 23.92 67.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50717 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 24.53 mmHg 3.8 11.4 vascular fluid filled catheter 50768 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -1.39 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50776 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 0.2 mmHg 1.98 5.25 vascular fluid filled catheter 50829 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -76.42 beats/min 10.6 21.21 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50867 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 26.0 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50894 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 5.44 beats/min 14.96 29.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50891 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 7.16 mmHg 5.12 13.55 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50919 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 2.79 mmHg 5.37 13.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50922 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 31.89 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50931 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 2.23 mmHg 1.67 4.71 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50937 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 3.95 mmHg 4.82 9.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50936 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -18.72 beats/min 14.13 28.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50954 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -5.6 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50955 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 8.59 mmHg 3.45 8.45 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50990 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 4.37 mmHg 1.82 5.15 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50995 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 5.65 mmHg 3.11 8.22 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50994 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 9.74 mmHg 1.98 6.85 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51104 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 5.27 mmHg 1.01 3.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51106 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 8.62 mmHg 1.62 4.27 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51107 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 6.71 mmHg 3.2 7.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51108 481
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 13 -2.4 ml/min/g 0.6 2.16 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67308 151
BN.GH-(D2Rat22-D2Mgh11)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132.0 days-146.0 days 19 330.6 g 5.96 26.0 body weighing method 11534 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 1.17 g 0.04 0.2 post excision weight measurement ng/kg/min 11546 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132.0 days-146.0 days 21 315.2 g 5.24 24.0 body weighing method 11548 101
BN/Elh single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 3.6 g/kg 0.09 0.4 post excision weight measurement ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11554 101
BN/Elh body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132.0 days-146.0 days 21 310.3 g 7.64 35.0 body weighing method 11555 101
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 8.96 mmHg 2.29 4.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51110 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -3.2 mmHg 2.21 5.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51133 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 4.02 mmHg 2.34 9.04 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51129 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 -6.04 mmHg 3.13 4.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51130 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.51 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51131 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -18.16 beats/min 10.99 29.07 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51215 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -9.45 beats/min 15.69 44.36 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51216 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -5.9 beats/min 15.92 38.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51237 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 2.17 beats/min 10.28 29.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51367 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -9.47 beats/min 6.99 20.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51366 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -10.48 beats/min 3.86 8.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51369 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 1.07 mmHg 3.41 10.22 vascular fluid filled catheter 51394 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 32.17 mmHg 4.7 13.29 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51493 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 1.15 mmHg 3.77 9.97 vascular fluid filled catheter 51625 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 4.2 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51658 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 25.5 mmHg 3.34 10.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51657 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 0.48 mmHg 1.96 4.81 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51663 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 31.19 mmHg 2.1 4.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51667 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 26.33 mmHg 3.02 7.4 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51668 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 4.15 beats/min 23.97 47.94 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51673 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 3.42 mmHg 1.85 4.89 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50342 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -71.27 beats/min 21.14 42.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50344 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -45.24 beats/min 26.63 70.44 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50347 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -45.27 beats/min 22.01 44.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50363 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 2.93 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50386 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -41.3 beats/min 29.44 88.33 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50427 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -3.15 beats/min 20.75 41.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50428 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 -0.2 mmHg 4.63 12.24 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50434 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 0.91 mmHg 0.26 0.36 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50433 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 3.03 mmHg 1.25 4.68 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50500 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -4.08 beats/min 19.02 42.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50505 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 31.47 beats/min 18.3 44.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50511 481
GH/Omr heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 4.7 mg/g 0.15 0.7 post excision weight measurement 0.0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68334 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 3.7 mg/g 0.07 0.3 post excision weight measurement 0.0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68337 101
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 159.0 mmHg 6.4 23.08 vascular indwelling catheter method left femoral artery 120.0 69538 151
LH/Mav renal blood flow rate bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 35.0 days 9 3.3 ml/min/g 0.2 0.6 ultrasonic flowmeter 0.0 104577 2970
LH/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 350.0 days 7 148.0 mmHg 5.0 13.23 vascular fluid filled catheter 0.0 104575 2970
LH/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112.0 days 8 8.7 ml/min/g 0.6 1.7 ultrasonic flowmeter 0.0 104579 2970
LL/Mav renal blood flow rate right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112.0 days 6 10.6 ml/min/g 0.7 1.71 ultrasonic flowmeter 0.0 104602 2970
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 16.22 mmHg 3.11 8.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51768 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 36.2 mmHg 2.54 6.73 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51775 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -3.3 beats/min 0.3 0.42 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51793 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 25.17 mmHg 2.4 8.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51867 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 21.1 mmHg 4.61 11.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51871 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -27.75 beats/min 7.94 30.77 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51923 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.68 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51962 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 24.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51965 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 15.84 mmHg 2.33 8.7 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51968 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -0.47 mmHg 3.39 10.17 vascular fluid filled catheter 52025 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 91.52 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52051 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 20.6 beats/min 13.45 26.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50513 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -37.31 beats/min 13.25 51.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50582 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -77.5 beats/min 34.7 49.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50583 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -20.32 beats/min 34.38 84.22 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50586 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -30.8 beats/min 7.68 18.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50591 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -21.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50682 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -1.47 beats/min 34.5 84.5 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50684 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.23 beats/min 4.03 9.87 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50689 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -40.21 beats/min 9.65 40.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50718 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 12 -31.9 beats/min 21.48 74.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50721 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 2.22 mmHg 2.02 7.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50777 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 3.46 mmHg 1.52 4.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50781 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 4.02 mmHg 8.2 20.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50783 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 10.07 beats/min 3.47 9.18 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50792 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 6.82 mmHg 1.9 4.64 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50817 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 5.25 beats/min 13.2 26.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50820 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 0.91 mmHg 2.27 4.55 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50818 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -0.2 mmHg 2.08 4.16 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50816 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 17.13 beats/min 16.45 32.89 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50893 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 8.33 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50915 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -3.73 mmHg 1.03 2.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50917 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 5.73 mmHg 2.57 8.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50930 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 11.69 mmHg 6.31 15.46 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50934 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 5.49 mmHg 2.01 2.84 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50993 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 0.07 beats/min 14.92 39.49 vascular fluid filled catheter 51041 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -19.05 beats/min 23.28 61.59 vascular fluid filled catheter 51043 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 0.91 mmHg 0.96 2.14 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51082 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -1.55 mmHg 1.88 3.77 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51081 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 1.56 mmHg 1.66 4.7 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51100 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 15.43 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51105 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 -1.0 mmHg 2.75 7.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51135 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -25.02 beats/min 12.07 26.99 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51213 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -22.91 beats/min 7.09 10.03 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51214 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -11.35 beats/min 12.39 24.77 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51241 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -49.04 beats/min 15.9 47.7 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51376 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 0.75 beats/min 17.84 35.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51377 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -20.91 beats/min 18.11 54.33 vascular fluid filled catheter 51413 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -7.77 beats/min 18.13 44.41 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51674 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -50.41 beats/min 16.19 32.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50336 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -48.51 beats/min 15.93 42.16 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50339 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -33.0 beats/min 25.62 72.46 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50348 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 4.01 mmHg 4.78 9.57 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50383 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -60.38 beats/min 7.16 21.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50417 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 12.97 beats/min 16.28 39.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50426 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 11.19 beats/min 19.05 53.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50503 481
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 19 serial mean 22.0 mmHg 3.0 13.08 vascular indwelling catheter method left femoral artery 0.0 67301 151
GH/Omr single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 3.4 g/kg 0.04 0.2 post excision weight measurement ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11526 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 19 3.7 g/kg 0.07 0.3 post excision weight measurement 0.0 ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11533 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 16 1.12 g 0.05 0.2 post excision weight measurement ng/kg/min 11539 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 16 3.7 g/kg 0.1 0.4 post excision weight measurement ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11540 101
BN/Elh kidney wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 1.12 g 0.02 0.1 post excision weight measurement ng/kg/min 11553 101
BN/Elh heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 1.15 g 0.03 0.13 post excision weight measurement 0.0 ng/kg/min 68333 101
BN.GH-(D2Rat22-D2Mgh11)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 19 3.4 mg/g 0.11 0.5 post excision weight measurement 0.0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68335 101
BN.GH-(D6Mit12-D6Rat15)/Mcwi heart left ventricle weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 16 3.8 mg/g 0.08 0.3 post excision weight measurement 0.0 ng/kg/min Original CMO ID was CMO:0000540. Corrected 2-15-2018. 68336 101
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 168.4 mmHg 7.0 25.24 vascular indwelling catheter method left femoral artery 120.0 69540 151
LH/Mav mean arterial blood pressure right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112.0 days 8 146.0 mmHg 5.0 14.14 vascular fluid filled catheter 0.0 104573 2970
LL/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 112.0 days 6 10.6 ml/min/g 0.7 1.71 ultrasonic flowmeter 0.0 104580 2970
LH/Mav glomerular filtration rate to kidney weight ratio right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 350.0 days 7 0.51 ml/min/g 0.13 0.34 ultrasonic flowmeter 0.0 104593 2970
LH/Mav mean arterial blood pressure right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 112.0 days 8 146.0 mmHg 5.0 14.14 vascular fluid filled catheter 0.0 104597 2970
LH/Mav glomerular filtration rate to kidney weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 112.0 days 8 0.99 ml/min/g 0.08 0.23 ultrasonic flowmeter 0.0 104609 2970
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 9.32 mmHg 2.42 6.86 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51740 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 27.25 mmHg 4.3 9.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51770 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 2.35 beats/min 11.45 28.06 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51790 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 5.85 beats/min 23.31 61.68 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51794 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 21.95 mmHg 2.41 6.38 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51861 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 16.35 mmHg 2.77 9.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51869 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 19.38 mmHg 3.3 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51873 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 13.05 mmHg 2.64 7.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51874 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 18.8 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51913 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -3.32 beats/min 20.7 62.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51918 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -33.57 beats/min 24.8 65.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51926 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -101.53 beats/min 14.79 44.38 vascular fluid filled catheter 51937 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 21.26 mmHg 2.2 8.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51963 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -4.08 mmHg 3.15 9.46 vascular fluid filled catheter 52023 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -32.36 beats/min 13.84 30.95 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52050 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 13.2 beats/min 21.2 56.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52055 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -26.95 beats/min 8.55 29.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52054 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -35.03 beats/min 21.41 56.65 vascular fluid filled catheter 52081 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -10.22 beats/min 19.9 59.69 vascular fluid filled catheter 52080 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -34.01 beats/min 27.27 81.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50580 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -20.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50581 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -48.54 beats/min 8.85 34.28 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50585 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -66.96 beats/min 13.29 51.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50587 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -58.69 beats/min 20.55 54.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50588 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 0.53 mmHg 1.24 2.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50601 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 15.65 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50602 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 12 3.2 mmHg 1.6 5.56 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50603 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 7.61 mmHg 2.63 6.95 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50606 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -18.2 beats/min 46.2 65.34 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50681 481
SS-Chr 20BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 26.95 beats/min 7.31 28.3 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50683 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 2.83 beats/min 19.88 56.24 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50687 481
SS-Chr 16BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 5 -38.96 beats/min 35.44 79.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50719 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 24.4 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50722 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -50.68 beats/min 14.96 51.82 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50723 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -11.63 beats/min 18.33 44.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50725 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -0.91 mmHg 3.29 9.86 vascular fluid filled catheter 50770 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 2.17 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50773 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 2 2.52 mmHg 6.42 9.08 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50775 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -1.42 mmHg 2.23 5.46 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50778 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 10.83 beats/min 10.18 20.36 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50822 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 3.21 beats/min 10.2 26.99 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50825 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -0.68 mmHg 4.11 12.32 vascular fluid filled catheter 50830 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 6.01 mmHg vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50860 481
Crl:CD(SD) absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 11.78 mmHg 2.52 5.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50857 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 6.57 beats/min 9.35 22.89 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50892 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 4.08 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50912 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.4 mmHg 1.79 3.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50921 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 -5.4 mmHg 2.47 10.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50927 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 1 -6.74 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50929 481
GH/OmrMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 7.25 mmHg 1.97 5.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50933 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -1.98 mmHg 1.94 5.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50935 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -27.15 beats/min 19.46 38.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50952 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -12.2 beats/min 20.46 50.11 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50953 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -53.36 beats/min 15.31 40.5 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50975 481
FHH/EurMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 -0.81 mmHg 2.41 6.83 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51085 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 9.79 mmHg 2.4 7.19 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51099 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 5 3.87 mmHg 2.0 4.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51102 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.6 mmHg 0.68 1.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51111 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 13.1 mmHg 2.68 8.04 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51127 481
SS-Chr 9BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 14 11.29 mmHg 3.25 12.16 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51134 481
SHR/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -0.23 mmHg 3.97 9.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51138 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -13.98 beats/min 6.5 15.92 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51211 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -13.26 beats/min 12.39 24.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51212 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -21.13 beats/min 8.39 25.18 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51231 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 4.3 beats/min 93.3 131.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51234 481
SS-Chr 9BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -15.78 beats/min 13.94 54.0 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51238 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -14.73 beats/min 16.5 40.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51242 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 89.93 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51370 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 19.91 beats/min 16.5 43.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51374 481
LEW/Crl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 0.85 mmHg 4.77 14.32 vascular fluid filled catheter 51396 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -24.26 beats/min 15.5 46.5 vascular fluid filled catheter 51411 481
LEW/Crl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 2.2 beats/min 15.19 40.18 vascular fluid filled catheter 51412 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 21.74 mmHg 2.32 4.63 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51489 481
SS-Chr 16BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 37.22 mmHg 3.1 8.19 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51492 481
Hsd:SD absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -5.39 beats/min 12.75 33.74 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 51615 481
SS-Chr 20BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 36.48 mmHg 2.7 10.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51662 481
Crl:CD(SD) absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 4.73 beats/min 17.72 35.45 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51675 481
F344/DuCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 8.4 beats/min vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 51676 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 6 -6.63 beats/min 20.93 51.28 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50335 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -16.95 beats/min 18.35 51.9 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50340 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -91.71 beats/min 8.29 11.72 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50346 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 2 -34.8 beats/min 65.4 92.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50356 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -32.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50357 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -65.03 beats/min 16.82 44.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50361 481
F344/DuCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 2.78 mmHg 1.91 4.67 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50384 481
SHR/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 105.2 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50423 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 -32.32 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50421 481
GH/OmrMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -16.29 beats/min 8.71 23.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50425 481
SS-Chr 18BN/Mcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 6 -1.93 mmHg 2.59 6.35 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50430 481
Hsd:SD absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.74 mmHg 2.53 6.7 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 50501 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 20.02 beats/min 10.69 32.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50502 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -9.03 beats/min 7.32 31.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50504 481
SS-Chr 18BN/Mcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 1 2.02 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50506 481
FHH/EurMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -24.77 beats/min 14.96 44.88 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50512 481
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 19 -1.4 ml/min/g 0.2 0.87 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67307 151
GH/Omr body weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. body mass male 132.0 days-146.0 days 21 365.4 g 3.71 17.0 body weighing method 11527 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi single kidney wet weight to body weight ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. kidney mass male 132.0 days-146.0 days 21 3.8 g/kg 0.09 0.4 post excision weight measurement ng/kg/min kidney wet weight to body weight ratio (CMO:0003389) 11547 101
BN.GH-(D18Rat41-D18Mgh4)/Mcwi heart left ventricle wet weight angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart left ventricle mass male 132.0 days-146.0 days 21 1.15 g 0.04 0.2 post excision weight measurement 0.0 ng/kg/min 68332 101
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 141.7 mmHg 7.4 26.68 vascular indwelling catheter method left femoral artery 120.0 69536 151
LH/Mav mean arterial blood pressure bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. arterial blood pressure trait male 35.0 days 9 94.0 mmHg 2.0 6.0 vascular fluid filled catheter 0.0 104571 2970
LL/Mav renal blood flow rate bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 35.0 days 9 4.9 ml/min/g 0.3 0.9 ultrasonic flowmeter 0.0 104578 2970
LL/Mav renal blood flow rate right adrenalectomy (between 9 and 10 days) and right nephrectomy (between 9 and 10 days) then left kidney denervation and left adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. renal blood flow trait male 350.0 days 7 10.2 ml/min/g 0.5 1.32 ultrasonic flowmeter 0.0 104582 2970
LH/Mav glomerular filtration rate to kidney weight ratio bilateral renal denervation and bilateral adrenalectomy then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. glomerular filtration trait male 35.0 days 9 0.99 ml/min/g 0.14 0.42 ultrasonic flowmeter 0.0 104589 2970
LH/Mav timed urine volume to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine output male 112.0 days 8 9.3 ul/min/g 1.4 3.96 urine volume measurement method 0.0 104613 2970
LL/Mav timed urine volume to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine output male 112.0 days 6 8.6 ul/min/g 1.6 3.92 urine volume measurement method 0.0 104614 2970
LL/Mav urine sodium excretion rate to body weight ratio right nephrectomy (between 9 and 10 days) then left kidney denervation then aldosterone (66 ng/kg/min) (for 1.5 hours) and hydrocortisone (33 ng/kg/min) (for 1.5 hours) and norepinephrine (333 ng/kg/min) (for 1.5 hours) and argipressin (0.17 ng/kg/min) (for 1.5 hours) then abdominal aorta constriction and celiac artery and superior mesenteric artery constriction Miao CY, et al., J Hypertens. 2005 Jun;23(6):1225-31. urine sodium amount male 112.0 days 6 0.56 uEq/min/g 0.18 0.44 urine sodium analysis 0.0 104618 2970
GH/Omr change in heart rate to change in vasoactive chemical dose ratio angiotensin II (5-50 ng/kg/min) (between 0.2 and 1 hours) then norepinephrine (0.1-1 ug/kg/min) (between 0.2 and 1 hours) then phenylephrine (4 ug/kg) (between 0 and 0 hours) Bilusic M, et al., Croat Med J. 2008 Oct;49(5):586-99. heart pumping trait male 132.0 days-146.0 days 14 -0.87 (beats/min)/(ug/kg) 0.07 0.25 vascular indwelling catheter method 0.0 ng/kg/min change in heart rate to change in vasoactive chemical dose ratio (CMO:0003904), (beats/min)/(ug/kg) 138468 101