| Hsd:SD |
blood monocyte count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
monocyte quantity |
female |
84.0 days
| 10 |
0.29 |
x 1000 cells/ul |
0.14 |
0.44 |
automated hematology analysis |
|
|
|
|
|
|
106052 |
3021 |
| Hsd:SD |
brain weight to body weight ratio |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
brain mass |
female |
84.0 days
| 10 |
0.74 |
% |
0.03 |
0.1 |
post excision weight measurement |
|
|
|
|
|
|
105908 |
3021 |
| Hsd:SD |
red blood cell count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
erythrocyte quantity |
female |
84.0 days
| 10 |
7.47 |
x 10E6 cells/ul |
0.21 |
0.66 |
automated hematology analysis |
|
|
|
|
|
|
105932 |
3021 |
| Hsd:SD |
blood hemoglobin level |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
blood hemoglobin amount |
female |
84.0 days
| 10 |
14.05 |
g/dl |
0.48 |
1.52 |
automated hematology analysis |
|
|
|
|
|
|
105944 |
3021 |
| Hsd:SD |
mean corpuscular hemoglobin concentration |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
blood hemoglobin amount |
female |
84.0 days
| 10 |
32.48 |
g/dl |
0.68 |
2.15 |
automated hematology analysis |
|
|
|
|
|
|
105992 |
3021 |
| Hsd:SD |
liver weight as percentage of body weight |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
liver mass |
female |
84.0 days
| 10 |
3.65 |
% |
0.2 |
0.63 |
post excision weight measurement |
|
0.0 |
|
|
|
|
105720 |
3021 |
| Hsd:SD |
white blood cell count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
leukocyte quantity |
female |
84.0 days
| 10 |
9.42 |
x 1000 cells/ul |
2.25 |
7.12 |
automated hematology analysis |
|
|
|
|
|
|
106016 |
3021 |
| Hsd:SD |
spleen weight to body weight ratio |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
spleen mass |
female |
84.0 days
| 10 |
0.3 |
% |
0.03 |
0.09 |
post excision weight measurement |
|
|
|
|
|
|
105896 |
3021 |
| Hsd:SD |
mean corpuscular volume |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
erythrocyte size trait |
female |
84.0 days
| 10 |
57.96 |
fl |
1.26 |
3.98 |
automated hematology analysis |
|
|
|
|
|
|
105968 |
3021 |
| Hsd:SD |
platelet count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
platelet quantity |
female |
84.0 days
| 10 |
1308.4 |
x 1000 /ul |
220.08 |
695.95 |
automated hematology analysis |
|
|
|
|
|
|
106004 |
3021 |
| Hsd:SD |
photopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled visible light condition (30 cd x s/m2) then visible light stimulus (12 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
cone electrophysiology trait |
both |
days
| 4 |
51.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
photopic b-wave ERG |
108644 |
3128 |
| Hsd:SD |
serum alanine aminotransferase activity level |
fasting (between 12 and 15 hours) then vehicle control condition (for 1 days) |
McGill MR, et al., Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94. doi: 10.1016/j.taap.2012.08.015. Epub 2012 Aug 23. |
blood alanine transaminase amount |
not specified |
56.0 days-84.0 days |
4 |
30.0 |
U/l |
1.0 |
2.0 |
spectrophotometry |
|
0.0 |
|
|
|
|
84757 |
1601 |
| Hsd:SD |
blood lymphocyte count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
lymphocyte quantity |
female |
84.0 days
| 10 |
7.36 |
x 1000 cells/ul |
1.77 |
5.6 |
automated hematology analysis |
|
|
|
|
|
|
106040 |
3021 |
| Hsd:SD |
blood eosinophil count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
eosinophil quantity |
female |
84.0 days
| 10 |
0.13 |
x 1000 cells/ul |
0.14 |
0.44 |
automated hematology analysis |
|
|
|
|
|
|
106064 |
3021 |
| Hsd:SD |
scotopic A wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
days
| 4 |
142.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
scotopic a-wave ERG |
108642 |
3128 |
| Hsd:SD |
both ovaries weight to body weight ratio |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
ovary mass |
female |
84.0 days
| 10 |
0.05 |
% |
0.01 |
0.03 |
post excision weight measurement |
|
|
|
|
|
|
105920 |
3021 |
| Hsd:SD |
hematocrit |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
erythrocyte quantity |
female |
84.0 days
| 10 |
43.31 |
% |
1.49 |
4.71 |
automated hematology analysis |
|
|
|
|
|
|
105956 |
3021 |
| Hsd:SD |
blood neutrophil count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
neutrophil quantity |
female |
84.0 days
| 10 |
1.48 |
x 1000 cells/ul |
0.85 |
2.69 |
automated hematology analysis |
|
|
|
|
|
|
106028 |
3021 |
| Hsd:SD |
thymus weight to body weight ratio |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
thymus mass |
female |
84.0 days
| 10 |
1.5 |
mg/g |
0.35 |
1.11 |
post excision weight measurement |
|
|
|
|
|
|
105884 |
3021 |
| Hsd:SD |
mean corpuscular hemoglobin |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
blood hemoglobin amount |
female |
84.0 days
| 10 |
18.82 |
pg |
0.44 |
1.39 |
automated hematology analysis |
|
|
|
|
|
|
105980 |
3021 |
| Hsd:SD |
blood basophil count |
vehicle control condition (5 ml/kg) (for 28 days) |
Harrill JA, et al., J Appl Toxicol. 2016 Jun;36(6):802-14. doi: 10.1002/jat.3211. Epub 2015 Aug 17. |
basophil quantity |
female |
84.0 days
| 10 |
0.07 |
x 1000 cells/ul |
0.03 |
0.09 |
automated hematology analysis |
|
|
|
|
|
|
106076 |
3021 |
| Hsd:SD |
scotopic B wave amplitude of ERG waveform |
vehicle control condition (2 ul) then controlled exposure to darkness (for 12 hours) then visible light stimulus (5 cd/m2) |
Conlon TJ, et al., Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8. doi: 10.1089/humc.2013.037. Epub 2013 Apr 3. |
rod electrophysiology trait |
both |
days
| 4 |
338.0 |
uV |
|
|
electroretinography |
cornea |
0.0 |
subretinal injection |
30 |
days |
scotopic b-wave ERG |
108640 |
3128 |