Phenominer Database Results (103 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Record ID Study ID
ACI/SegHsd percentage of study population developing pituitary tumors during a period of time 17 beta-estradiol (27.5 mg) (between 146 and 202 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 pituitary gland integrity trait female 207 days-265 days 21 100.0 % ex vivo visual assessment 0 0 65551 76
F344.BN-(D16Mit5-D16Rat75) serum estradiol level orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) and 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood estradiol amount male 0 days 5 25.7 pg/ml 2.33 5.2 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67444 655
BN/SsNHsd percentage of study population developing mammary tumors during a period of time 17 beta-estradiol (27.5 mg) (between 196 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 259 days 13 0.0 % manual palpation method 0 crystalline implant 0 65765 81
BN/SsNHsd binary logarithm of pituitary gland wet weight surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Shull JD, et al., Mamm Genome. 2007 Sep 18;. pituitary gland mass female 252 days-266 days 10 3.79 null 0.07 0.21 post excision weight measurement pituitary gland 0 0 logarithm of pituitary wet weight 65768 331
ACI/SegHsd mammary tumor number 17 beta-estradiol (27.5 mg) (between 99 and 197 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 mammary gland integrity trait female 160 days-260 days 20 5.6 null necropsy 0.0 0 tumor size reach 1-1.5 cm 11377 76
COP/OlaHsd mammary tumor number 17 beta-estradiol (27.5 mg) (between 212 and 330 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 271 days-397 days 20 0.4 null 0.13 0.6 manual palpation method 0 0 11753 144
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 99 and 197 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 mammary gland integrity trait female 160 days-260 days 21 serial mean 145.0 d manual palpation method mammary gland 0.0 0 66104 76
F344.BN-(D16Mit5-D16Rat75) ratio of proliferating cell nuclear antigen-positive cells to total liver tumorous lesion cells orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 3.55 % 0.98 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal pcna index 68107 655
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 0.18 cm3 x 10000 0.11 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67793 655
SR/JrHsd single kidney wet weight controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. kidney mass female 0 days 0 0.88 g 0.02 post excision weight measurement 0.0 0 102199 2681
SR/JrHsd single kidney wet weight controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. kidney mass female 0 days 0 1.11 g 0.02 post excision weight measurement 0.0 0 102200 2681
SS.ZUC-Leprfa-/-/Slc retroperitoneal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. retroperitoneal fat pad mass female 91 days 7 377.0 mg/mm 33.0 87.31 post excision weight measurement 0.0 ovariectomy 42 days 101702 2622
SS.ZUC-Leprfa+/+/Slc inguinal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. inguinal fat pad mass female 91 days 12 19.0 mg/mm 1.0 3.46 post excision weight measurement 0.0 ovariectomy 42 days sf/tl 101704 2622
SS/JrHsd uterus weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. uterus mass female 112 days 6 0.44 g 0.01 0.02 post excision weight measurement 0.0 ovx 63 days 102354 2686
SS.ZUC-Leprfa+/+/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 12 39.0 ms 1.0 3.46 echocardiography 0.0 ovariectomy 42 days 101736 2622
SS.ZUC-Leprfa+/+/Slc left ventricular end-diastolic blood pressure bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 12 4.03 mmHg 0.28 0.97 vascular transducer tipped catheter 0.0 ovariectomy 42 days 101744 2622
SS.ZUC-Leprfa-/-/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 7 62.4 ms 3.3 8.73 echocardiography 0.0 ovariectomy 42 days 101750 2622
ACI.COP-(D6Rat80-D6Rat146)/Shul post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 0 days-259 days 17 165.0 d manual palpation method 0 0 median 11371 75
SS/JrHsd body weight controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. body mass female 0 days 0 211.0 g 4.6 body weighing method 0.0 0 102193 2681
COP/CrCrl mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 7 0.1 null 0.15 0.4 necropsy 0 11370 75
COP/OlaHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 212 and 330 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 212 days-330 days 7 median 195.0 d manual palpation method 0 median 11751 144
SR/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 42.9 pg/ml 12.6 30.86 radioimmunoassay 0.0 ovx 63 days 102363 2686
SS/JrHsd single kidney wet weight controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. kidney mass female 0 days 0 1.1 g 0.07 post excision weight measurement 0.0 0 102205 2681
SR/JrHsd glomerular filtration rate to kidney weight ratio controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. glomerular filtration trait female 0 days 0 1.97 ml/min/g 0.25 inulin analysis by liquid phase colorimetry 0.0 0 102215 2681
SS.ZUC-Leprfa-/-/Slc heart weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart mass female 91 days 7 0.35 g/cm 0.0 0.0 post excision weight measurement 0.0 ovariectomy 42 days 101694 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 7 2.16 mm 0.06 0.16 echocardiography 0.0 ovariectomy 42 days 101714 2622
SS.ZUC-Leprfa+/+/Slc calculated heart left ventricle weight bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 12 589.0 mg 31.0 107.39 echocardiography 0.0 ovariectomy 42 days 101724 2622
SS.ZUC-Leprfa+/+/Slc E wave deceleration time bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 12 53.6 ms 1.4 4.85 echocardiography 0.0 ovariectomy 42 days 101732 2622
BN/SsNHsd pituitary gland wet weight surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Shull JD, et al., Mamm Genome. 2007 Sep 18;. pituitary gland mass female 252 days-266 days 10 0.01 g 0.0 0.0 post excision weight measurement pituitary gland 0.0 0 13102 331
ACI/SegHsd mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 21 7.0 null 1.16 5.3 necropsy 0 11368 75
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 103.0 fmol/mg 13.0 radioimmunoassay 0.0 0 102227 2681
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 90.2 fmol/mg 9.9 radioimmunoassay 0.0 0 102232 2681
SS.ZUC-Leprfa+/+/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 12 0.15 cm 0.0 0.01 echocardiography 0.0 ovariectomy 42 days 101708 2622
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 99 and 197 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 mammary gland integrity trait female 160 days-260 days 21 median 143.0 d manual palpation method mammary gland 0.0 0 66111 76
ACI.COP-(D10Mgh8-D10Rat4)/Shul mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 12 4.8 null 1.04 3.6 necropsy 0 11366 75
ACI/SegHsd percentage of study population developing mammary tumors during a period of time bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 mammary gland integrity trait female 201 days-203 days 11 0.0 % manual palpation method mammary gland 0 0 11379 76
COP/OlaHsd percentage of study population developing mammary tumors during a period of time 17 beta-estradiol (27.5 mg) (between 212 and 330 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 212 days-330 days 7 43.8 % manual palpation method 0 0 mean 66113 144
ACI/SegHsd percentage of study population developing mammary tumors during a period of time 17 beta-estradiol (27.5 mg) (for 197 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 mammary gland integrity trait female 160 days-260 days 21 100.0 % manual palpation method mammary gland 0 0 65549 76
SS.ZUC-Leprfa-/-/Slc heart left ventricle weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 7 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 ovariectomy 42 days 101698 2622
SS.ZUC-Leprfa-/-/Slc inguinal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. inguinal fat pad mass female 91 days 7 155.0 mg/mm 14.0 37.04 post excision weight measurement 0.0 ovariectomy 42 days sf/tl 101706 2622
SS.ZUC-Leprfa-/-/Slc body weight bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 7 339.0 g 13.0 34.39 body weighing method 0.0 ovariectomy 42 days 101664 2622
SS.ZUC-Leprfa+/+/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 12 33.6 mm 0.2 0.69 body length measuring method 0.0 ovariectomy 42 days 101666 2622
SS.ZUC-Leprfa-/-/Slc tibia straight segment length bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. tibia length female 91 days 7 31.8 mm 0.6 1.59 body length measuring method 0.0 ovariectomy 42 days 101668 2622
SS.ZUC-Leprfa+/+/Slc heart rate bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 12 392.0 beats/min 5.0 17.32 tail cuff plethysmography 0.0 ovariectomy 42 days 101674 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 7 7.1 mm 0.12 0.32 echocardiography 0.0 ovariectomy 42 days 101718 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle fractional shortening bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 7 61.3 % 2.7 7.14 echocardiography 0.0 ovariectomy 42 days 101722 2622
SS/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 82.7 fmol/mg 5.8 radioimmunoassay 0.0 0 102231 2681
F344.BN-(D16Mit5-D16Rat75) serum testosterone level orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. blood testosterone amount male 0 days 5 0.85 ng/ml 0.03 0.07 immunoassay 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67443 655
ACI/SegHsd percentage of study population developing pituitary tumors during a period of time bilateral ovariectomy then 17 beta-estradiol (27.5 mg) (for 140 days) Shull JD, et al., Carcinogenesis. 1997 Aug;18(8):1595-601 pituitary gland integrity trait female 201 days-203 days 11 100.0 % ex vivo visual assessment 0 0 65561 76
SS.ZUC-Leprfa-/-/Slc myocardial performance index bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 7 0.99 null 0.03 0.08 echocardiography 0.0 ovariectomy 42 days 101742 2622
SS.ZUC-Leprfa+/+/Slc time constant of left ventricular pressure decay bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 12 46.8 ms 2.9 10.05 echocardiography 0.0 ovariectomy 42 days 101748 2622
SS/JrHsd body weight controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. body mass female 0 days 0 228.0 g 6.1 body weighing method 0.0 0 102194 2681
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 143 days-259 days 22 median 133.0 d manual palpation method 0 crystalline implant 0 65763 81
ACI.COP-(D6Rat80-D6Rat146)/Shul mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 17 2.4 null 0.41 1.7 necropsy 0 11360 75
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 143 days-259 days 22 136.0 d 6.0 28.14 manual palpation method 0.0 crystalline implant 0 11383 81
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 147 and 195 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 206 days-264 days 31 141.0 d 4.85 27.0 manual palpation method 0 mean 11748 144
COP/OlaHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 212 and 330 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 212 days-330 days 7 208.0 d 7.56 20.0 manual palpation method 0 mean 11749 144
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (between 147 and 195 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 206 days-264 days 31 median 140.0 d manual palpation method 0 median 11750 144
SR/JrHsd body weight controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. body mass female 0 days 0 213.0 g 2.2 body weighing method 0.0 0 102188 2681
SS/JrHsd mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. arterial blood pressure trait female 0 days 0 132.0 mmHg 2.0 vascular fluid filled catheter 0.0 0 102212 2681
SS/JrHsd glomerular filtration rate to kidney weight ratio controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. glomerular filtration trait female 0 days 0 1.96 ml/min/g 0.04 inulin analysis by liquid phase colorimetry 0.0 0 102218 2681
SS.ZUC-Leprfa+/+/Slc heart left ventricle weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 12 0.18 g/cm 0.0 0.01 post excision weight measurement 0.0 ovariectomy 42 days lv/tl 101696 2622
SS/JrHsd body weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. body mass female 112 days 6 241.6 g 5.0 12.25 body weighing method 0.0 ovx 63 days 102342 2686
SR/JrHsd body weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. body mass female 112 days 6 209.5 g 5.3 12.98 body weighing method 0.0 ovx 63 days 102345 2686
SR/JrHsd both kidneys wet weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. kidney mass female 112 days 6 1.53 g 0.05 0.12 post excision weight measurement 0.0 ovx 63 days 102351 2686
SR/JrHsd uterus weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. uterus mass female 112 days 6 0.46 g 0.01 0.02 post excision weight measurement 0.0 ovx 63 days 102357 2686
SS.ZUC-Leprfa-/-/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 7 0.81 mmHg/mm 0.03 0.08 echocardiography 0.0 ovariectomy 42 days 101754 2622
SS.ZUC-Leprfa+/+/Slc body weight bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. body mass female 91 days 12 220.0 g 4.0 13.86 body weighing method 0.0 ovariectomy 42 days 101662 2622
SS.ZUC-Leprfa+/+/Slc systolic blood pressure bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. arterial blood pressure trait female 91 days 12 undefined 141.0 mmHg 4.0 13.86 tail cuff plethysmography 0.0 ovariectomy 42 days 101670 2622
SS.ZUC-Leprfa-/-/Slc heart rate bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 7 366.0 beats/min 8.0 21.17 tail cuff plethysmography 0.0 ovariectomy 42 days 101676 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle fractional shortening bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 12 55.2 % 1.9 6.58 echocardiography 0.0 ovariectomy 42 days 101720 2622
SS.ZUC-Leprfa-/-/Slc calculated heart left ventricle weight bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle mass female 91 days 7 1176.0 mg 46.0 121.7 echocardiography 0.0 ovariectomy 42 days 101726 2622
SS.ZUC-Leprfa-/-/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 7 61.0 % 2.0 5.29 echocardiography 0.0 ovariectomy 42 days 101730 2622
SS.ZUC-Leprfa-/-/Slc left ventricular end-diastolic blood pressure bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 7 5.91 mmHg 0.18 0.48 vascular transducer tipped catheter 0.0 ovariectomy 42 days 101746 2622
SR/JrHsd adrenal angiotensin II type 1 receptor density controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. adrenal gland molecular composition trait female 0 days 0 94.8 fmol/mg 9.2 radioimmunoassay 0.0 0 102228 2681
F344.BN-(D16Mit5-D16Rat75) volume of liver occupied by tumorous lesions as percentage of total liver volume orchiectomy then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 19.0 % 5.4 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal 67446 655
ACI/SegHsd binary logarithm of pituitary gland wet weight surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Shull JD, et al., Mamm Genome. 2007 Sep 18;. pituitary gland mass female 252 days-266 days 9 7.15 null 0.12 0.36 post excision weight measurement pituitary gland 0 0 logarithm of pituitary wet weight 65770 331
ACI/SegHsd pituitary gland wet weight surgical implantation then 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Shull JD, et al., Mamm Genome. 2007 Sep 18;. pituitary gland mass female 252 days-266 days 9 0.15 g 0.01 0.04 post excision weight measurement pituitary gland 0 0 13093 331
ACI/SegHsd post-insult time to mammary tumor formation 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 0 days-259 days 21 145.0 d manual palpation method 0 0 median 11375 75
ACI/SegHsd percentage of study population developing mammary tumors during a period of time 17 beta-estradiol (27.5 mg) (between 147 and 195 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 206 days-264 days 31 100.0 % manual palpation method 0 0 mean 66112 144
ACI.COP-(D3Rat130-D3Rat114)/Shul mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 17 4.5 null 0.73 3.0 necropsy 0 11364 75
ACI/SegHsd mammary tumor number 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 143 days-259 days 22 8.8 null 1.4 6.57 manual palpation method 0.0 crystalline implant 0 11382 81
F344.BN-(D16Mit5-D16Rat75) liver tumorous lesion number to liver volume ratio orchiectomy then N-nitrosodiethylamine (200 mg/kg) (for 56 days) then 17 beta-estradiol (3.3 mg/kg) (for 21 days) then 17 beta-estradiol (10 mg/kg) (for 35 days) De Miglio MR, et al., Cancer Res. 2006 Nov 1;66(21):10384-90. liver integrity trait male 0 days 0 16820.0 /cm3 5100.0 ex vivo light microscopy with digital image analysis 0.0 N-nitrosodiethylamine injection at 200mg/kg 56 days intraperitoneal Add 67445 655
ACI/SegHsd mammary tumor number 17 beta-estradiol (27.5 mg) (between 144 and 195 days) Shull JD, et al., Endocrinology 2001 Dec;142(12):5124-30 mammary gland integrity trait female 203 days-264 days 34 3.9 null 0.6 3.5 manual palpation method 0 0 11752 144
SS/JrHsd plasma estradiol level controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. blood estradiol amount female 112 days 6 21.2 pg/ml 3.2 7.84 radioimmunoassay 0.0 ovx 63 days 102360 2686
SR/JrHsd body weight controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. body mass female 0 days 0 200.0 g 2.5 body weighing method 0.0 0 102187 2681
SS/JrHsd single kidney wet weight controlled sodium chloride content diet (4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. kidney mass female 0 days 0 1.71 g 0.08 post excision weight measurement 0.0 0 102206 2681
SR/JrHsd mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 14 days) then bilateral ovariectomy then 17 beta-estradiol (10 ug/d) (for 14 days) Zheng W, et al., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1508-13. doi: 10.1152/ajpheart.01322.2007. Epub 2008 Feb 1. arterial blood pressure trait female 0 days 0 112.0 mmHg 5.0 vascular fluid filled catheter 0.0 0 102209 2681
SS.ZUC-Leprfa-/-/Slc heart ventricle septal wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 7 0.21 cm 0.01 0.01 echocardiography 0.0 ovariectomy 42 days 101710 2622
SS/JrHsd both kidneys wet weight controlled sodium content diet (0.1 %) (for 112 days) then bilateral ovariectomy (between 56 and 63 days) and 17 beta-estradiol (5 mg) (between 56 and 63 days) Esqueda ME, et al., Hypertension. 2007 Oct;50(4):768-72. Epub 2007 Aug 13. kidney mass female 112 days 6 1.95 g 0.09 0.22 post excision weight measurement 0.0 ovx 63 days 102348 2686
SS.ZUC-Leprfa-/-/Slc systolic blood pressure bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. arterial blood pressure trait female 91 days 7 undefined 202.0 mmHg 6.0 15.87 tail cuff plethysmography 0.0 ovariectomy 42 days 101672 2622
SS.ZUC-Leprfa+/+/Slc heart weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart mass female 91 days 12 0.23 g/cm 0.0 0.01 post excision weight measurement 0.0 ovariectomy 42 days 101682 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle posterior wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle posterior wall thickness female 91 days 12 1.4 mm 0.02 0.07 echocardiography 0.0 ovariectomy 42 days 101712 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle end-diastolic diameter bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle end-diastolic diameter female 91 days 12 6.5 mm 0.17 0.59 echocardiography 0.0 ovariectomy 42 days 101716 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricle relative wall thickness bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricle wall thickness female 91 days 12 45.0 % 1.0 3.46 echocardiography 0.0 ovariectomy 42 days 101728 2622
SS.ZUC-Leprfa-/-/Slc E wave deceleration time bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 7 59.9 ms 1.0 2.65 echocardiography 0.0 ovariectomy 42 days 101734 2622
SS.ZUC-Leprfa-/-/Slc heart isovolumetric relaxation time bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart muscle relaxation trait female 91 days 7 57.9 ms 4.2 11.11 echocardiography 0.0 ovariectomy 42 days 101738 2622
SS.ZUC-Leprfa+/+/Slc heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart left ventricular blood pressure trait female 91 days 12 0.63 mmHg/mm 0.05 0.17 echocardiography 0.0 ovariectomy 42 days 101752 2622
ACI/SegHsd percentage of study population developing mammary tumors during a period of time 17 beta-estradiol (27.5 mg) (between 193 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 143 days-259 days 22 94.0 % manual palpation method 0 crystalline implant 0 65764 81
ACI.COP-(D3Mgh16-D3Rat119)/Shul mammary tumor number 17 beta-estradiol (27.5 mg) (for 196 days) Kurz SG, et al., Endocrinology. 2008 Apr 17 mammary gland integrity trait female 259 days 8 4.3 null 1.13 3.2 necropsy 0 11362 75
BN/SsNHsd mammary tumor number 17 beta-estradiol (27.5 mg) (between 196 and 199 days) Schaffer BS, et al., Cancer Res. 2006 Aug 1;66(15):7793-800 mammary gland integrity trait female 259 days 13 0.0 null manual palpation method crystalline implant 0 11381 81
SS.ZUC-Leprfa+/+/Slc retroperitoneal fat pad weight to tibia length ratio bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. retroperitoneal fat pad mass female 91 days 12 49.0 mg/mm 3.0 10.39 post excision weight measurement 0.0 ovariectomy 42 days vf/tl 101700 2622
SS.ZUC-Leprfa+/+/Slc myocardial performance index bilateral ovariectomy (for 42 days) then 17 beta-estradiol (0.5 mg) (for 35 days) Murase T, et al., Hypertension. 2012 Mar;59(3):694-704. doi: 10.1161/HYPERTENSIONAHA.111.180976. Epub 2012 Jan 23. heart pumping trait female 91 days 12 0.57 null 0.03 0.1 echocardiography 0.0 ovariectomy 42 days 101740 2622