Phenominer Database Results (44 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS.BN-(D12Arb13-D12Rat79)/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 9 1.96 ml/min 0.15 0.44 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52142 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 9 0.49 ng/ml/h 0.16 0.49 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52436 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 10 41.24 mg/d 7.04 22.27 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52585 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 -7.36 null 0.11 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56081 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 0.03 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56235 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 99.64 % 0.36 1.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56305 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 40.23 % 4.6 16.59 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55078 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 0.88 E-7mole 0.18 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56496 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -7.15 null 0.08 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56891 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 10 184.5 mg/d 28.5 90.11 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52685 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 1.26 g/mg 0.06 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57310 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 1.57 g/mg 0.07 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57318 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 52.09 % 4.31 14.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54764 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -7.27 null 0.1 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56089 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 0.06 umol/l 0.01 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54882 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 39.62 % 4.85 17.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56278 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 15 292.6 g 3.2 12.2 whole body digital scale Moms and pups used in studies were fed Teklad 55161 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 0.91 E-7mole 0.19 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56504 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 8 1.68 ml/min 0.46 1.31 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52146 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 9 181.29 mmHg 4.8 14.41 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52834 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 8 0.34 mg/dl 0.04 0.1 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52195 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 10 415.28 beats/min 9.27 29.32 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52632 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 12 15.1 mEq/d 1.32 4.57 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52732 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 10 10.85 mEq/d 1.44 4.55 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52736 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 45.83 % 4.05 14.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54756 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -8.48 null 0.05 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56018 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 -8.57 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56023 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 15 196.5 g 3.4 13.0 whole body digital scale Moms and pups used in studies were fed Teklad 55168 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 35.3 % 5.41 17.11 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57141 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 10 190.68 mmHg 5.29 16.74 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52830 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 12 1.33 mEq/d 0.07 0.25 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52928 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 9 427.95 beats/min 12.74 38.22 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52636 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 12 302.91 mg/d 22.58 78.21 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52681 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.04 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56230 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 35.07 % 3.43 12.82 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55073 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 37.42 % 4.68 16.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57136 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 10 0.95 mEq/d 0.12 0.39 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52932 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 9 0.38 mg/dl 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52191 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 8 1.01 ng/ml/h 0.34 0.95 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52440 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 12 86.57 mg/d 11.34 39.28 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52581 482
SS.BN-(D12Arb13-D12Rat79)/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.07 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54890 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 34.0 % 3.98 14.88 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56273 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 98.67 % 1.2 4.64 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56310 522
SS.BN-(D12Arb13-D12Rat79)/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 11 -7.15 null 0.1 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56899 522