| LE/BluGill |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80.0 days-99.0 days |
7 |
|
1.18 |
mEq/d |
0.06 |
0.15 |
flame atomic emission spectrometry |
|
|
urine potassium analysis |
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52926 |
482 |
| LE/BluGill |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80.0 days-99.0 days |
6 |
|
2.56 |
ml/min |
0.2 |
0.5 |
urine creatinine analysis |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52291 |
482 |
| LE/BluGill |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80.0 days-99.0 days |
9 |
|
2.14 |
ml/min |
0.15 |
0.45 |
urine creatinine analysis |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52290 |
482 |
| LE/BluGill |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80.0 days-99.0 days |
7 |
|
7.25 |
mg/d |
1.35 |
3.56 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52434 |
482 |
| LE/BluGill |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80.0 days-99.0 days |
8 |
|
3.46 |
ng/ml/h |
1.44 |
4.09 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52578 |
482 |
| LE/BluGill |
percent change in ventilation |
controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82.0 days-99.0 days |
10 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
153.14 |
% |
14.59 |
46.14 |
stop flow air displacement plethysmography |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
19305 |
381 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
33.71 |
% |
3.38 |
12.65 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55002 |
522 |
| LE/BluGill |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
-8.48 |
null |
0.06 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55116 |
522 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
11 |
|
44.91 |
% |
2.37 |
7.87 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56708 |
522 |
| LE/BluGill |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
14 |
|
-8.37 |
null |
0.09 |
0.34 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56743 |
522 |
| LE/BluGill |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80.0 days-99.0 days |
9 |
|
5.33 |
mg/d |
0.83 |
2.48 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52433 |
482 |
| LE/BluGill |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
14 |
|
0.01 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57434 |
522 |
| LE/BluGill |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
62.79 |
% |
2.82 |
10.56 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55387 |
522 |
| LE/BluGill |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70.0 days-84.0 days |
14 |
|
393.6 |
g |
8.2 |
30.7 |
whole body digital scale |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56077 |
522 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
10 |
|
37.7 |
% |
1.82 |
5.76 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56712 |
522 |
| LE/BluGill |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70.0 days-84.0 days |
14 |
|
1.71 |
g/mg |
0.13 |
0.47 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56870 |
522 |
| LE/BluGill |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80.0 days-99.0 days |
9 |
|
16.09 |
mEq/d |
2.02 |
6.07 |
flame atomic emission spectrometry |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52827 |
482 |
| LE/BluGill |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80.0 days-99.0 days |
7 |
|
112.29 |
mmHg |
0.72 |
1.91 |
vascular fluid filled catheter |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52242 |
482 |
| LE/BluGill |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80.0 days-99.0 days |
6 |
|
0.32 |
mg/dl |
0.02 |
0.05 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52240 |
482 |
| LE/BluGill |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80.0 days-99.0 days |
9 |
|
429.78 |
beats/min |
17.94 |
53.83 |
vascular fluid filled catheter |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52629 |
482 |
| LE/BluGill |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80.0 days-99.0 days |
7 |
|
382.48 |
beats/min |
3.97 |
10.5 |
vascular fluid filled catheter |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52630 |
482 |
| LE/BluGill |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80.0 days-99.0 days |
9 |
|
36.08 |
mg/d |
5.08 |
15.23 |
automated urine total protein analysis |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52729 |
482 |
| LE/BluGill |
percent change in ventilation |
controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82.0 days-99.0 days |
13 |
%change=VE during7-9 min hypoxia/control during standard conditions |
144.14 |
% |
5.01 |
18.07 |
stop flow air displacement plethysmography |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
17342 |
381 |
| LE/BluGill |
percent change in ventilation |
controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82.0 days-99.0 days |
13 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
151.33 |
% |
5.57 |
20.09 |
stop flow air displacement plethysmography |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
19309 |
381 |
| LE/BluGill |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
13 |
|
44.31 |
% |
5.54 |
19.96 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55391 |
522 |
| LE/BluGill |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
0.52 |
E-7mole |
0.13 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55983 |
522 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
|
29.36 |
% |
3.99 |
14.92 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55006 |
522 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
|
37.29 |
% |
4.05 |
15.17 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56834 |
522 |
| LE/BluGill |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
15 |
|
2.3 |
g/mg |
0.16 |
0.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56866 |
522 |
| LE/BluGill |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80.0 days-99.0 days |
7 |
|
23.29 |
mEq/d |
1.27 |
3.37 |
flame atomic emission spectrometry |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52828 |
482 |
| LE/BluGill |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80.0 days-99.0 days |
9 |
|
0.33 |
mg/dl |
0.02 |
0.07 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52239 |
482 |
| LE/BluGill |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80.0 days-99.0 days |
6 |
|
4.74 |
ng/ml/h |
1.34 |
3.27 |
radioimmunoassay |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52579 |
482 |
| LE/BluGill |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80.0 days-99.0 days |
7 |
|
39.37 |
mg/d |
5.21 |
13.77 |
automated urine total protein analysis |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52730 |
482 |
| LE/BluGill |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
13 |
|
0.88 |
E-7mole |
0.18 |
0.63 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55987 |
522 |
| LE/BluGill |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
-7.41 |
null |
0.09 |
0.33 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
54748 |
522 |
| LE/BluGill |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
13 |
|
-7.17 |
null |
0.09 |
0.33 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
54752 |
522 |
| LE/BluGill |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
|
-8.28 |
null |
0.06 |
0.24 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
55120 |
522 |
| LE/BluGill |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
15 |
|
-8.67 |
null |
0.04 |
0.17 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
EC50 value is moles/liter |
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56739 |
522 |
| LE/BluGill |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
0.04 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56767 |
522 |
| LE/BluGill |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
|
0.08 |
10E-7mol/l |
0.02 |
0.08 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56771 |
522 |
| LE/BluGill |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56856 |
522 |
| LE/BluGill |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70.0 days-84.0 days |
14 |
|
99.21 |
% |
0.53 |
1.97 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56860 |
522 |
| LE/BluGill |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80.0 days-99.0 days |
9 |
|
1.09 |
mEq/d |
0.1 |
0.29 |
flame atomic emission spectrometry |
|
|
urine potassium analysis |
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52925 |
482 |
| LE/BluGill |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80.0 days-99.0 days |
9 |
|
113.88 |
mmHg |
4.03 |
12.09 |
vascular fluid filled catheter |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan |
52241 |
482 |
| LE/BluGill |
percent change in ventilation |
controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82.0 days-99.0 days |
10 |
%change=VE during7-9 min hypoxia/control during standard conditions |
139.08 |
% |
9.71 |
30.72 |
stop flow air displacement plethysmography |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
17338 |
381 |
| LE/BluGill |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70.0 days-84.0 days |
15 |
|
0.0 |
umol/l |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57430 |
522 |
| LE/BluGill |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70.0 days-84.0 days |
15 |
|
272.5 |
g |
6.3 |
24.6 |
whole body digital scale |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56073 |
522 |
| LE/BluGill |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70.0 days-84.0 days |
14 |
|
43.07 |
% |
2.87 |
10.74 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
56830 |
522 |