Phenominer Database Results (168 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15228 381
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 2 26.1 mmHg 0.5 0.71 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17238 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.29 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13918 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 115.86 % 10.91 34.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53878 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 7.55 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17041 381
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 7 286.86 U/l 9.86 26.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36377 401
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 2 369.86 beats/min 16.67 23.57 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17501 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 130.2 breaths/min 13.87 41.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18263 381
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 839.88 s 32.23 91.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49297 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 87.98 mmHg 4.28 12.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49886 461
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 8 4.05 g/dl 0.03 0.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42228 401
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 8 0.15 x 1000 cells/ul 0.05 0.15 automated blood cell counting method Moms and pups used in studies were fed Teklad 39669 401
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 7 0.33 x 1000 cells/ul 0.07 0.19 automated blood cell counting method Moms and pups used in studies were fed Teklad 39672 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 8 31.83 g/dl 0.15 0.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 39772 401
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 8 0.57 x 1000 cells/ul 0.08 0.23 automated blood cell counting method Moms and pups used in studies were fed Teklad 43219 401
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 218.1 g 7.1 22.6 whole body digital scale Moms and pups used in studies were fed Teklad 59060 526
SS-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 7 1.77 g/dl 0.02 0.05 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40548 401
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 8 10.41 mg/dl 0.51 1.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37589 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 8 22.75 mg/dl 1.18 3.33 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40823 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 7 21.43 mg/dl 1.25 3.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40826 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 8 5.89 x 1000 cells/ul 0.32 0.92 automated blood cell counting method Moms and pups used in studies were fed Teklad 40921 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 8 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41642 401
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.91 g 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45403 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 253.0 beats/min 10.05 30.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47577 461
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 85.95 % 4.33 12.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48754 461
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 21.14 ml/min/kg 0.92 2.59 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57798 526
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.5 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58111 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 1.06 mg/kg 0.12 0.32 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58904 526
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 12.16 ml/min/g 0.6 1.7 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46651 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 30.89 IU/g 3.64 10.3 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45971 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 39.65 % 4.17 12.52 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47072 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 47.71 % 4.02 11.37 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47075 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 5.28 mmHg 0.39 1.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47192 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 4.4 mmHg 0.33 0.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47195 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 64.7 mmHg 2.72 7.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46415 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 0.41 IU/g 0.1 0.28 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47453 461
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 131.74 % 9.32 27.96 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13678 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 -7.1 mmHg 0.7 0.99 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19630 381
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 8 178.5 U/l 6.51 18.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36374 401
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 8 5.71 g/dl 0.07 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36957 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 7 73.71 mg/dl 4.38 11.6 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37095 401
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 7 9.54 mg/dl 0.08 0.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36622 401
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 41.93 ml/min 2.51 7.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20206 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.13 degrees C 0.41 1.3 digital rectal thermometry Moms and pups used in studies were fed Teklad 20304 381
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 60.43 mmHg 5.98 8.45 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20468 381
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 1056.33 s 32.23 96.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50222 461
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 8 63.58 fl 0.4 1.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 38740 401
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 7 62.46 fl 0.47 1.24 automated blood cell counting method Moms and pups used in studies were fed Teklad 38743 401
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 8 22.38 mmol/l 0.73 2.07 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42057 401
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 7 3.64 g/dl 0.04 0.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42231 401
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 8 105.13 mmol/l 0.74 2.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39112 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 8 68.5 U/l 3.16 8.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42765 401
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 169.5 g 4.2 13.4 whole body digital scale Moms and pups used in studies were fed Teklad 59057 526
SS-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 8 1.66 g/dl 0.05 0.13 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40545 401
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.52 g/kg 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59652 526
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 17.76 g/dl 0.1 0.27 automated blood cell counting method Moms and pups used in studies were fed Teklad 37966 401
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 8 5.14 x 1000 cells/ul 0.29 0.82 automated blood cell counting method Moms and pups used in studies were fed Teklad 41498 401
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 7 0.14 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41866 401
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 37.36 % 4.24 12.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48522 461
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 14.63 ml/min/kg 0.62 1.75 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57596 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 55.93 ml/min/kg 6.51 19.53 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57994 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 43.81 ml/min/kg 2.49 7.48 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57997 526
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58487 526
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.18 g/kg 0.19 0.61 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45623 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 5.85 ml/min/g 0.63 1.79 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44716 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 74.5 % 4.01 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48290 461
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 118.96 breaths/min 6.82 20.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14792 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 2 103.61 mmHg 24.88 35.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14328 381
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 2 26.73 mmHg 1.43 2.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17234 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.38 ml 0.04 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13921 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 112.01 % 9.49 28.47 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53881 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 -30.72 mmHg 4.68 6.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19456 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 155.27 breaths/min 13.8 43.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18260 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 31.66 ml/min 1.84 5.83 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20203 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 0.58 degrees C 0.18 0.55 digital rectal thermometry Moms and pups used in studies were fed Teklad 20307 381
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 158.7 g 4.5 14.3 whole body digital scale Moms and pups used in studies were fed Teklad 49520 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 7 20.24 % 3.13 8.28 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49696 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 36.13 mmHg 2.72 7.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49995 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 1037.38 s 26.13 73.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50225 461
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 7 20.71 mmol/l 0.42 1.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42060 401
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 55.91 % 0.38 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 38989 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 8 8.54 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 39232 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 19.86 pg 0.15 0.4 automated blood cell counting method Moms and pups used in studies were fed Teklad 42543 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 7 142.0 mmol/l 1.36 3.61 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39386 401
SS-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 7 0.33 mg/dl 0.04 0.1 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39574 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 31.76 g/dl 0.09 0.24 automated blood cell counting method Moms and pups used in studies were fed Teklad 39775 401
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 7 152.57 mg/dl 5.16 13.65 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38528 401
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 8 0.15 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41863 401
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 266.65 beats/min 6.08 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47580 461
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 22.32 % 4.85 13.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48525 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 96.09 mmHg 5.9 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48619 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 96.51 mmHg 5.2 14.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48622 461
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.44 null 0.02 0.05 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58728 526
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.44 null 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58731 526
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 101.37 mmHg 6.0 18.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45724 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 100.91 mmHg 5.01 14.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45727 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 11.02 ml/min/g 0.65 1.95 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46648 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 59.85 mmHg 4.35 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46412 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 81.76 % 4.45 10.89 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48293 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 23.28 mmHg 4.42 12.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45268 461
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 122.56 breaths/min 6.84 21.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14789 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 124.62 mmHg 13.43 26.85 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14323 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 115.2 % 8.47 25.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53749 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 105.11 % 6.89 21.8 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53979 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 105.46 % 5.47 16.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53982 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 -8.27 mmHg 0.03 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19626 381
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 7 5.41 g/dl 0.04 0.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36960 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 8 68.0 mg/dl 2.49 7.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37092 401
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 46.63 ml/min 3.67 11.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18660 381
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 403.95 beats/min 35.32 70.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17496 381
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 8 9.64 mg/dl 0.1 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36619 401
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 66.4 mmHg automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20473 381
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 824.78 s 43.86 131.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49294 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 16.26 % 3.05 9.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49693 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 40.22 mmHg 4.9 14.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49992 461
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 8 54.24 % 0.54 1.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 38986 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 8 20.24 pg 0.09 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 42540 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 8 141.5 mmol/l 1.05 2.98 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39383 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 7 84.0 U/l 5.39 14.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42768 401
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 149.73 % 14.83 46.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54319 381
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 7 0.84 x 1000 cells/ul 0.1 0.27 automated blood cell counting method Moms and pups used in studies were fed Teklad 43222 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 8 47.38 U/l 3.78 10.69 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40709 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 7 61.43 U/l 4.58 12.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40712 401
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.28 g/kg 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59655 526
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 8 3.99 mmol/l 0.14 0.39 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38061 401
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 4.6 mmol/l 0.22 0.57 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38064 401
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 7 19.0 mmol/l 0.65 1.73 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38259 401
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 7 6.16 x 1000 cells/ul 0.44 1.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 41501 401
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 8 144.38 mg/dl 2.77 7.84 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38525 401
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.9 g 0.05 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45400 461
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 18.26 ml/min/kg 0.72 2.17 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57593 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 7 1.59 mg/kg 0.55 1.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58901 526
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 23.95 IU/g 2.61 7.82 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45969 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 6 222.21 beats/min 12.58 30.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45146 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 187.87 beats/min 11.71 35.13 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45143 461
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.36 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15231 381
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 162.77 % 10.09 31.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13675 381
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 0.04 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19777 381
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 0.02 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19782 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 118.23 % 8.27 26.14 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53746 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 7.5 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17046 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 43.46 ml/min 3.61 11.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18657 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 -34.8 mmHg automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19461 381
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 176.0 g 3.0 9.5 whole body digital scale Moms and pups used in studies were fed Teklad 49525 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 94.24 mmHg 2.77 8.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49883 461
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 7 106.86 mmol/l 1.16 3.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39115 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 8.95 x 10E6 cells/ul 0.09 0.24 automated blood cell counting method Moms and pups used in studies were fed Teklad 39235 401
SS-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 8 0.38 mg/dl 0.03 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39571 401
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 125.58 % 14.01 42.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54322 381
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 8 54.24 % 0.54 1.53 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59252 526
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 55.91 % 0.38 0.99 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59255 526
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 7 10.1 mg/dl 0.33 0.86 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37592 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 7 7.33 x 1000 cells/ul 0.55 1.45 automated blood cell counting method Moms and pups used in studies were fed Teklad 40924 401
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 0.12 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59542 526
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.15 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59545 526
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 8 17.27 g/dl 0.21 0.58 automated blood cell counting method Moms and pups used in studies were fed Teklad 37963 401
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 8 17.88 mmol/l 0.61 1.73 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38256 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 7 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method Moms and pups used in studies were fed Teklad 41645 401
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 94.83 % 4.7 14.11 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48751 461
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 27.52 ml/min/kg 1.56 4.67 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57795 526
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.06 degrees C 0.41 1.3 digital rectal thermometry Moms and pups used in studies were fed Teklad 16567 381
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 37.27 degrees C 0.25 0.75 digital rectal thermometry Moms and pups used in studies were fed Teklad 16570 381
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 0.53 null 0.04 0.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58108 526
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58484 526
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.69 g/kg 0.26 0.81 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45618 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 4.47 ml/min/g 0.63 1.88 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44713 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 0.2 IU/g 0.05 0.16 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47449 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 34.39 mmHg 3.29 9.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45265 461