Phenominer Database Results (168 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.35 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15290 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 110.93 breaths/min 8.36 28.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14851 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.36 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13980 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.29 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13985 381
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19790 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 111.21 breaths/min 5.04 16.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18327 381
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 78.92 mmHg 4.85 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49943 461
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 7 109.14 mmol/l 0.7 1.86 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39173 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 8.94 x 10E6 cells/ul 0.1 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 39293 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 6 0.43 mg/dl 0.05 0.12 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39637 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 7 0.32 x 1000 cells/ul 0.04 0.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 39730 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 32.47 g/dl 0.25 0.67 automated blood cell counting method Moms and pups used in studies were fed Teklad 39833 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 7 1.7 g/dl 0.03 0.08 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40606 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 7 48.07 % 1.54 4.06 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59318 526
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 7 9.56 mg/dl 0.38 1.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37650 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 7 7.23 x 1000 cells/ul 0.41 1.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 40982 401
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 15 1.38 g/kg 0.04 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59713 526
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 5.47 mmol/l 0.24 0.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38122 401
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 6 4.32 mmol/l 0.27 0.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38127 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41703 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 7 138.29 mg/dl 1.87 4.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38586 401
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 0.53 IU/g 0.08 0.23 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47462 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 257.14 beats/min 8.39 25.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47637 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 81.85 mmHg 6.08 19.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48684 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 86.88 % 6.39 19.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48811 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 96.28 % 4.53 13.6 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48816 461
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 13.43 ml/min/kg 0.72 2.38 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57654 526
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.27 degrees C 0.15 0.48 digital rectal thermometry Moms and pups used in studies were fed Teklad 16634 381
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 12 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58550 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 15 0.43 null 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58789 526
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 5.33 ml/min/g 0.36 1.03 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44773 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 4.86 mmHg 0.41 1.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47252 461
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 104.28 % 7.07 23.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54047 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 127.74 mmHg 7.4 16.55 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14336 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 2 26.75 mmHg 4.15 5.87 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17252 381
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 0.0 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19796 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 43.24 ml/min 4.31 14.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18719 381
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 6 199.17 U/l 29.69 72.72 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36440 401
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 6 9.48 mg/dl 0.27 0.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36685 401
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 30.86 ml/min 2.29 7.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20270 381
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 0.11 degrees C 0.25 0.86 digital rectal thermometry Moms and pups used in studies were fed Teklad 20366 381
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 6 844.83 s 29.58 72.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49354 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 11.09 % 2.64 7.92 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49758 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1134.3 s 50.23 158.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50287 461
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 7 59.33 fl 0.48 1.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 38806 401
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 6 109.5 mmol/l 0.92 2.26 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39178 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 6 144.5 mmol/l 1.09 2.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39449 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 7 0.2 x 1000 cells/ul 0.05 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 39735 401
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 14 131.0 g 7.5 28.0 whole body digital scale Moms and pups used in studies were fed Teklad 59123 526
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 6 50.67 U/l 7.6 18.61 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40775 401
SS-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 7 23.43 mg/dl 1.25 3.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40884 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 7 5.56 x 1000 cells/ul 0.69 1.82 automated blood cell counting method Moms and pups used in studies were fed Teklad 40987 401
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59608 526
SS-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 16.96 g/dl 0.27 0.7 automated blood cell counting method Moms and pups used in studies were fed Teklad 38024 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 6 154.33 mg/dl 18.87 46.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38591 401
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 268.88 beats/min 13.6 40.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47642 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 26.21 % 6.91 20.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48582 461
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 6 1.51 mg/kg 0.37 0.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58967 526
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 6.19 g/kg 0.33 1.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45640 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 88.16 mmHg 5.92 18.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45789 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 6.31 mmHg 0.25 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47257 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 78.73 % 3.86 11.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48355 461
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 131.71 % 6.41 22.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13737 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 123.77 % 9.64 31.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53814 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 113.73 % 4.34 15.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53941 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 109.67 % 6.85 22.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53946 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 120.99 breaths/min 8.33 28.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18322 381
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 6 5.27 g/dl 0.11 0.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37023 401
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 7 5.56 g/dl 0.13 0.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37018 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 7 76.71 mg/dl 3.68 9.74 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37153 401
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 -41.7 mmHg 8.05 16.11 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19469 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 -58.5 mmHg 10.7 15.13 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19475 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 61.05 mmHg 2.85 4.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20487 381
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 932.6 s 36.18 114.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49359 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 8 20.92 % 5.35 15.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49753 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 34.5 mmHg 3.14 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50057 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1046.22 s 43.57 130.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50282 461
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 6 20.17 mmol/l 1.11 2.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42123 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 6 3.77 g/dl 0.13 0.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42294 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 8.12 x 10E6 cells/ul 0.28 0.73 automated blood cell counting method Moms and pups used in studies were fed Teklad 39298 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 7 88.29 U/l 4.25 11.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42826 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 6 67.83 U/l 5.58 13.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42831 401
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 117.12 % 6.91 23.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54382 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 124.51 % 10.02 33.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54387 381
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 31.96 g/dl 0.21 0.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 39838 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 7 0.78 x 1000 cells/ul 0.07 0.19 automated blood cell counting method Moms and pups used in studies were fed Teklad 43280 401
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 6 11.27 mg/dl 0.7 1.72 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37655 401
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 7 4.58 x 1000 cells/ul 0.68 1.79 automated blood cell counting method Moms and pups used in studies were fed Teklad 41564 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 6 19.0 mmol/l 1.84 4.52 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38322 401
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 56.19 mmHg 4.66 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46472 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 59.04 mmHg 4.3 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46477 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 87.22 mmHg 4.06 12.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48679 461
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 14.94 ml/min/kg 1.39 4.8 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57659 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 19.73 ml/min/kg 1.38 4.59 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57856 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 14 0.41 null 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58794 526
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.39 g/kg 0.36 1.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45634 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 10.41 ml/min/g 1.05 2.96 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46708 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 9.12 ml/min/g 0.68 2.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46713 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 18.62 IU/g 3.31 9.36 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45978 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 15.78 IU/g 1.02 3.22 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45983 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 88.25 % 1.92 5.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48350 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 30.01 mmHg 4.66 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45330 461
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15295 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 111.3 breaths/min 5.55 18.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14856 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 140.79 mmHg 7.38 16.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14342 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 131.38 % 6.78 22.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13742 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 107.12 % 5.25 18.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53809 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -5.0 mmHg 1.05 2.09 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19638 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 32.36 ml/min 2.01 6.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18724 381
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 406.64 beats/min 9.8 21.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17515 381
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 7 9.1 mg/dl 0.1 0.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36680 401
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.15 degrees C 0.22 0.72 digital rectal thermometry Moms and pups used in studies were fed Teklad 20371 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 61.72 mmHg 1.84 4.51 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20481 381
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 89.04 mmHg 6.57 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49948 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 28.0 mmHg 1.77 5.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50052 461
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 7 58.47 fl 0.54 1.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 38801 401
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 7 21.57 mmol/l 1.17 3.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42118 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 52.26 % 0.74 1.95 automated blood cell counting method Moms and pups used in studies were fed Teklad 39047 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 7 3.86 g/dl 0.11 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42289 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 18.99 pg 0.26 0.69 automated blood cell counting method Moms and pups used in studies were fed Teklad 42601 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 18.96 pg 0.12 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 42606 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 7 144.0 mmol/l 0.58 1.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39444 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 7 0.31 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39632 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 7 0.76 x 1000 cells/ul 0.14 0.36 automated blood cell counting method Moms and pups used in studies were fed Teklad 43285 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 6 1.5 g/dl 0.04 0.09 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40611 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 6 0.15 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41929 401
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.62 g 0.04 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45460 461
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.75 g 0.04 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45465 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 32.48 % 4.75 14.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48587 461
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.36 degrees C 0.22 0.75 digital rectal thermometry Moms and pups used in studies were fed Teklad 16629 381
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 60.83 ml/min/kg 8.03 26.62 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58060 526
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.43 null 0.03 0.12 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58174 526
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 11 1.2 mg/kg 0.21 0.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58962 526
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 92.09 mmHg 3.83 11.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45784 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 55.22 % 6.66 18.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47132 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 48.99 % 3.5 11.07 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47137 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 228.17 beats/min 8.63 24.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45203 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 201.83 beats/min 12.42 39.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45208 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 22.73 mmHg 5.51 16.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45325 461
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 110.05 % 5.59 19.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54042 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 6 29.25 mmHg 1.05 2.58 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17246 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 -6.65 mmHg 1.05 1.48 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19644 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17054 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 7.52 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17060 381
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 7 251.29 U/l 14.1 37.3 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36435 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 6 84.67 mg/dl 3.35 8.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37158 401
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 400.21 beats/min 26.78 59.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17509 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 37.93 ml/min 3.4 11.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20265 381
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 117.1 g 6.8 21.5 whole body digital scale Moms and pups used in studies were fed Teklad 49536 461
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 122.4 g 5.6 17.6 whole body digital scale Moms and pups used in studies were fed Teklad 49542 461
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 48.07 % 1.54 4.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 39052 401
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 15 184.0 g 12.4 47.9 whole body digital scale Moms and pups used in studies were fed Teklad 59118 526
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 7 58.71 U/l 3.84 10.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40770 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 52.26 % 0.74 1.95 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59313 526
SS-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 6 30.67 mg/dl 2.47 6.06 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40889 401
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59603 526
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 12 1.45 g/kg 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59718 526
SS-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 15.39 g/dl 0.48 1.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 38029 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 7 18.71 mmol/l 1.08 2.87 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38317 401
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 7 6.12 x 1000 cells/ul 0.44 1.15 automated blood cell counting method Moms and pups used in studies were fed Teklad 41559 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41708 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41924 401
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.39 IU/g 0.03 0.11 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47467 461
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 25.32 ml/min/kg 2.58 8.95 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57861 526
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 12 47.56 ml/min/kg 6.07 21.04 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58055 526
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.47 null 0.04 0.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58169 526
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 14 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58545 526
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 4.3 ml/min/g 0.16 0.5 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44778 461