Phenominer Database Results (308 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 124.46 breaths/min 7.44 28.81 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15506 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 104.23 breaths/min 4.64 17.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15507 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 16 425.19 beats/min 13.38 53.54 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15756 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 16 113.71 mmHg 3.83 15.33 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13664 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 48.46 mmHg 1.59 4.2 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17311 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.13 % 8.25 31.97 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13899 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 101.13 breaths/min 4.32 16.73 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17933 381
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 5 55.2 % 11.56 25.85 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36283 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 3 7.6 mg/dl 1.69 2.92 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36296 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 3 5.33 g/dl 0.67 1.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36343 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 4 65.2 fl 0.92 1.83 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36714 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 16 9.63 mg/dl 0.17 0.7 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36729 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 5 236.6 mg/dl 27.35 61.16 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36739 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 3 9.43 mg/dl 1.51 2.61 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36838 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 5 11.76 mg/dl 0.58 1.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36837 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 2 22.0 mmol/l 0.0 0.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36845 401
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 51.25 ml/min 3.04 11.78 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19297 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 19 37.05 degrees C 0.21 0.89 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20292 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 7 -51.59 mmHg 1.82 4.8 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20407 381
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 58.59 % 29.76 51.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49269 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 3 61.67 mmHg 7.8 13.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49596 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 2 post-ischemic value/pre-ischemic value x 100% 84.42 % 22.3 31.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49656 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 905.67 s 30.38 96.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49664 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 13 1034.7 s 53.29 192.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49663 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 3 316.28 beats/min 18.91 32.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49979 461
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 5 6.22 mmol/l 0.2 0.46 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38860 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 17 117.12 U/l 6.96 28.7 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42173 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 5 2.2 g/dl 0.18 0.39 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38974 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 2 21.5 mmol/l 0.5 0.71 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42339 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 18 44.11 U/l 3.56 15.12 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42344 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 5 26.6 mg/dl 1.69 3.78 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39986 401
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 39.48 ml/min/kg 5.03 12.33 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59029 526
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 16 106.0 mmol/l 0.47 1.9 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40657 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 5 364.0 U/l 185.15 414.01 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37569 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 3 0.33 mg/dl 0.09 0.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37578 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 18 21.56 mg/dl 1.12 4.74 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40811 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 5 144.0 mmol/l 2.35 5.24 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37785 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 5 114.4 U/l 38.38 85.82 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41169 401
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 261.19 beats/min 14.7 25.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46504 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 304.18 beats/min 25.52 76.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46632 461
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.42 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16324 381
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 8 1.02 g/kg 0.03 0.09 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58196 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 7 0.33 null 0.03 0.07 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58318 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 8 212.4 g 4.8 13.6 whole body digital scale Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58436 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 20.29 ml/min/kg 1.74 4.27 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58466 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 19.67 ml/min/kg 1.66 4.07 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58708 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 5 1.01 mg/kg 0.28 0.63 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58883 526
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 3 68.36 mmHg 3.47 6.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45910 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 73.83 % 5.99 10.38 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47891 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 3 6.54 mmHg 0.24 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48015 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 50.56 % 3.84 13.85 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48116 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 49.04 % 6.43 21.32 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48117 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 3 1.37 g 0.05 0.1 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45033 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 11 12.69 ml/min/g 1.22 4.04 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45053 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 3 0.04 IU/g 0.01 0.02 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48386 461
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 0.48 ml 0.02 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14008 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 69.69 ml/min 4.23 9.46 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19716 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 0.08 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20696 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 12 27.16 mmHg 0.72 2.48 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17017 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 138.6 % 6.48 25.11 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17019 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 54.97 ml/min 5.38 12.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18962 381
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 5 9.06 mg/dl 0.61 1.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36295 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 5 20.48 pg 0.82 1.84 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36568 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 16 141.94 mmol/l 0.48 1.91 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36593 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 18 142.56 mmol/l 0.93 3.96 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36595 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 5 25.0 mmol/l 0.84 1.87 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36844 401
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 %change=VE during 2-3 min hypoxia/control during standard conditions 187.88 % 14.16 31.67 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19300 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 37.05 degrees C 0.19 0.76 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20293 381
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 114.45 mmHg 11.98 20.75 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49277 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 3 0.33 IU/g 0.14 0.24 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49620 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 97.19 mmHg 8.19 21.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49623 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 81.12 % 6.24 19.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49626 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 116.33 mmHg 7.03 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49650 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 2 140.09 mmHg 12.52 17.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49805 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 2 123.77 mmHg 11.21 15.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49809 461
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 56.82 % 0.48 1.86 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38851 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 18.24 g/dl 0.12 0.47 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38874 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 3 3.5 g/dl 0.5 0.87 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42337 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 16 54.13 U/l 5.89 23.57 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42342 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 4 34.63 g/dl 1.12 2.24 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42503 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 18 22.83 mmol/l 0.78 3.33 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39487 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 15 0.41 x 1000 cells/ul 0.08 0.32 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39535 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 18 0.47 mg/dl 0.03 0.11 automated plasma creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39543 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 18 92.39 mg/dl 4.17 17.69 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43106 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 5 163.4 % 14.9 33.32 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54525 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 102.66 % 4.05 15.68 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54567 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 118.15 % 4.62 17.89 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53570 381
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 3 20.67 mg/dl 0.33 0.58 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39987 401
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 21.73 ml/min/kg 1.16 3.08 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59027 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 8 0.37 null 0.02 0.05 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59145 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 6 0.38 null 0.03 0.08 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59146 526
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 4 1.52 x 1000 cells/ul 0.49 0.98 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40664 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 16 0.26 mg/dl 0.02 0.07 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37532 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 3 166.67 U/l 22.42 38.84 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37570 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 19.41 pg 0.12 0.49 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37565 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 16 9.18 mg/dl 0.14 0.57 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37573 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 16 61.14 fl 0.35 1.4 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37801 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 15 61.77 fl 0.65 2.53 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37799 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37805 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 16 0.07 x 1000 cells/ul 0.03 0.11 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37807 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 32.08 g/dl 0.12 0.46 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41117 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 31.77 g/dl 0.16 0.64 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41119 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 16 9.08 x 10E6 cells/ul 0.18 0.71 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38194 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 4 0.06 x 1000 cells/ul 0.03 0.06 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41609 401
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 9.75 IU/g 1.75 5.24 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45488 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 63.36 mmHg 7.08 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46531 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 2 post-ischemic value/pre-ischemic value x 100% 55.97 % 5.53 7.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47529 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 11 0.24 IU/g 0.04 0.12 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48707 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 7 21.24 % 3.11 8.22 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48740 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 2 410.89 beats/min 17.95 25.39 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16122 381
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57782 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 4 1.42 mg/kg 0.31 0.63 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57983 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 5 1.14 g/kg 0.03 0.07 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58197 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 14.43 ml/min/kg 0.99 2.42 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58707 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58711 526
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 7.5 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17455 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 0.41 ml 0.03 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16032 381
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 119.08 mmHg 9.14 25.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47784 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 65.05 mmHg 23.59 40.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45906 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 27.26 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46963 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 81.22 % 6.92 11.99 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47887 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 634.09 s 50.65 160.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47895 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 35.35 mmHg 4.97 13.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46148 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.2 mmHg 0.29 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48169 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 13 1.56 g 0.05 0.18 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45062 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 1082.73 s 172.33 298.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45106 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 3 1111.09 s 144.75 250.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45110 461
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 98.48 % 7.58 16.96 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54197 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 113.27 mmHg 6.46 20.44 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13663 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.54 % 7.3 28.27 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13898 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 -6.5 mmHg automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20980 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 5 37.68 degrees C 0.32 0.73 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19990 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 -0.86 degrees C 0.24 0.97 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20672 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 121.58 breaths/min 8.14 31.52 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17932 381
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 7.51 null automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18090 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 141.14 % 5.99 23.18 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17018 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 12 -8.11 mmHg 1.01 3.51 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18818 381
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 16 221.0 U/l 15.8 63.19 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37278 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 4 162.5 U/l 11.27 22.55 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36725 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 3 215.0 mg/dl 55.0 95.26 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36740 401
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 37.43 ml/min 1.6 6.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19298 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 5 144.23 breaths/min 7.06 15.79 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18206 381
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 3 19.87 % 11.92 20.64 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49033 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 3 9.47 % 2.98 5.16 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49037 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 3 0.31 IU/g 0.07 0.12 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49622 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 86.7 mmHg 7.37 23.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49624 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 2 post-ischemic value/pre-ischemic value x 100% 88.39 % 1.7 2.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49660 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 380.39 beats/min 29.41 88.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49849 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 349.14 beats/min 30.12 85.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49848 461
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 3 6.17 mmol/l 0.52 0.91 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38861 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 17.64 g/dl 0.3 1.19 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38876 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 5 20.4 mmol/l 1.12 2.51 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42338 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 5 31.4 g/dl 1.02 2.29 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42502 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 4 20.4 g/dl 1.16 2.33 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39372 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 16 0.3 x 1000 cells/ul 0.04 0.17 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39537 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 16 0.41 mg/dl 0.02 0.1 automated plasma creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39541 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 15 7.95 x 1000 cells/ul 0.63 2.44 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39547 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 16 5.93 x 1000 cells/ul 0.48 1.94 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39549 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 18 4.34 g/dl 0.07 0.3 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42965 401
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 108.45 % 3.59 13.89 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54568 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 117.74 % 11.68 26.11 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53612 381
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 15 1.0 x 1000 cells/ul 0.13 0.49 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43407 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 16 2.26 g/dl 0.08 0.34 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40497 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 18 2.28 g/dl 0.08 0.32 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40499 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 5 91.0 mg/dl 11.77 26.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37528 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 18 0.25 mg/dl 0.01 0.06 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37534 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 16 20.75 mg/dl 0.8 3.19 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40809 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 5 0.1 x 1000 cells/ul 0.03 0.08 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41608 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 5 0.54 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41730 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 4 0.5 x 1000 cells/ul 0.06 0.12 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41831 401
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 2 272.73 beats/min 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46508 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 56.3 mmHg 4.75 15.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46532 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 2 post-ischemic value/pre-ischemic value x 100% 52.78 % 35.43 50.11 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47525 461
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57773 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 57.83 % 0.47 1.24 microhematocrit tube assay with visual assessment Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57777 526
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.37 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16325 381
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 8 1.52 mg/kg 0.29 0.81 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57982 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 6 0.08 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58096 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 7 0.38 null 0.02 0.05 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58316 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 18.56 ml/min/kg 0.73 1.93 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58428 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 30.66 ml/min/kg 2.45 5.99 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58430 526
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 5 0.95 null 0.07 0.16 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58438 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 11.96 ml/min/kg 0.33 0.88 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58464 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 6 216.7 g 8.0 19.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58598 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 8 317.5 g 3.7 10.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58597 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 7 1.03 g/kg 0.02 0.05 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58703 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 53.57 % 1.73 4.57 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58816 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 5 57.32 % 0.36 0.81 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58817 526
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 2 133.65 mmHg 12.39 17.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47669 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 2 117.08 mmHg 11.54 16.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47673 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 3 49.18 mmHg 6.63 11.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45940 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 25.36 % 4.89 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46962 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 6.53 mmHg 0.12 0.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48011 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 13 12.15 ml/min/g 1.17 4.22 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45052 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 3 9.99 ml/min/g 1.73 2.99 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45086 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 3 9.7 ml/min/g 0.85 1.47 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45090 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 10 427.86 beats/min 13.06 41.31 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15755 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 54.19 mmHg 0.97 3.35 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17312 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 5 %change=VE during7-9 min hypoxia/control during standard conditions 145.08 % 6.1 13.63 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17333 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 2 115.72 mmHg 14.37 20.32 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13876 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 -0.47 degrees C 0.26 1.12 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20671 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 49.35 mmHg automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17006 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 7 28.14 mmHg 1.03 2.73 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17016 381
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 4 58.8 % 1.58 3.17 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36284 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 5 6.16 g/dl 0.19 0.43 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36342 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 18 6.63 g/dl 0.12 0.51 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37410 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 18 18.17 mmol/l 0.44 1.86 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36589 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 5 65.28 fl 1.27 2.84 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36713 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 18 9.51 mg/dl 0.06 0.27 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36731 401
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 -47.88 mmHg 2.49 8.64 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20408 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 5 0.34 degrees C 0.25 0.56 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19154 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 11 48.89 mmHg 4.88 16.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49161 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 3 117.54 mmHg 9.47 16.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49281 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 75.29 % 7.5 21.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49625 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 76.76 % 4.67 14.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49813 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 306.3 beats/min 21.43 37.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49975 461
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 5 3.96 g/dl 0.07 0.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42336 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 18 4.13 mmol/l 0.08 0.35 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39335 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 137.4 % 6.97 26.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53541 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 5 150.44 % 11.99 26.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53601 381
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 18 105.67 mmol/l 0.87 3.71 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40659 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 2 82.5 mg/dl 2.5 3.54 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37529 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 18 8.86 mg/dl 0.16 0.68 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37575 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 5 0.34 mg/dl 0.02 0.05 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37577 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 3 141.0 mmol/l 2.52 4.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37786 401
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.8 null 0.05 0.12 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59744 526
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 8.92 x 10E6 cells/ul 0.3 1.18 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38192 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 5 2.4 x 1000 cells/ul 0.54 1.21 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41732 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 5 0.71 x 1000 cells/ul 0.15 0.33 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41830 401
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 17.99 IU/g 4.36 10.69 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45487 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 264.79 beats/min 37.41 105.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46631 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 0.13 IU/g 0.04 0.09 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48706 461
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57774 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57781 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 12.87 ml/min/kg 1.13 2.76 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57784 526
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 29.5 mmHg automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16363 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 0.04 null automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16665 381
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.72 null 0.06 0.16 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58439 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58713 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 1.61 mg/kg 0.31 0.83 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58881 526
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 6 27.62 ml/min/kg 1.83 4.48 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60093 526
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17454 381
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 49.4 mmHg 11.63 20.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45936 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 30.4 mmHg 6.89 21.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46149 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 3 7.07 ml/min/g 0.32 0.55 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46183 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 11 1.3 g 0.1 0.34 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45063 461
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.46 ml 0.03 0.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13834 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.4 ml 0.02 0.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13835 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 0.07 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20697 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 132.93 % 5.74 22.25 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53967 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 127.71 % 5.44 21.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53968 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 -50.4 mmHg automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20686 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 5 133.26 breaths/min 6.2 13.86 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17556 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 7 -8.6 mmHg 1.68 4.44 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18817 381
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 18 123.06 U/l 9.73 41.27 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37280 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 16 6.31 g/dl 0.11 0.43 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37408 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 4 22.58 pg 0.94 1.88 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36569 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 16 17.38 mmol/l 0.64 2.55 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36587 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 3 105.0 U/l 14.43 25.0 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36726 401
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 40.2 ml/min 2.09 8.09 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19435 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 54.3 ml/min 3.56 13.81 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19434 381
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 13 49.58 mmHg 4.1 14.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49160 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 86.24 % 8.12 14.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49265 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 3 63.33 mmHg 11.57 20.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49592 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 124.98 mmHg 8.52 24.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49649 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 66.38 % 10.23 28.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49812 461
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 16 55.51 % 1.05 4.2 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38853 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 16 92.06 U/l 5.43 21.71 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42171 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 3 1.83 g/dl 0.18 0.31 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38975 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 16 4.46 mmol/l 0.13 0.53 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39333 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 5 17.64 g/dl 3.77 8.42 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39371 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 16 23.13 mmol/l 0.81 3.22 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39485 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 16 4.05 g/dl 0.06 0.24 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42963 401
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 16 75.13 mg/dl 2.81 11.22 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43104 401
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 131.46 % 5.91 22.91 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53542 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 113.26 % 5.31 20.56 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53569 381
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 16 0.8 x 1000 cells/ul 0.12 0.49 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43409 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 16 4.77 x 1000 cells/ul 0.4 1.59 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40515 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 15 6.5 x 1000 cells/ul 0.51 1.96 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40513 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 5 1.57 x 1000 cells/ul 0.4 0.9 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40663 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 19.85 pg 0.24 0.93 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37563 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 3 46.67 U/l 6.67 11.55 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41170 401
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.87 null 0.06 0.16 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59742 526
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 5 8.55 x 10E6 cells/ul 1.82 4.07 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37946 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 4 9.01 x 10E6 cells/ul 0.15 0.3 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37947 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 5 105.0 mmol/l 2.47 5.52 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38374 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 3 104.33 mmol/l 1.2 2.08 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38375 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 3 0.37 mg/dl 0.12 0.21 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41731 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 4 2.08 x 1000 cells/ul 0.47 0.94 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41733 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 18 170.72 mg/dl 4.42 18.76 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38627 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 16 187.88 mg/dl 5.73 22.93 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38625 401
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 13 15.23 % 2.26 8.15 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48739 461
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 7 54.11 % 1.48 3.92 microhematocrit tube assay with visual assessment Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57779 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 10.22 ml/min/kg 0.81 1.99 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57783 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 7 0.13 mmHg-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58094 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 7 323.6 g 4.5 12.0 whole body digital scale Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58434 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 6 1.2 g/kg 0.07 0.16 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58705 526
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 5 15.62 ml/min/kg 0.67 1.49 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60092 526
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 111.22 mmHg 7.0 20.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47785 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 13 5.82 ml/min/g 0.48 1.72 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46841 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 7.09 ml/min/g 0.94 2.97 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46842 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 13 699.88 s 51.24 184.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47894 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 3 8.32 ml/min/g 1.98 3.42 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46179 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 2 90.87 s 18.17 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48123 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 3 102.04 s 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48127 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 5.57 mmHg 0.9 2.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48168 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 3 1.23 g 0.07 0.11 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45037 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 3 0.02 IU/g 0.01 0.01 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48382 461