Phenominer Database Results (421 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 116.7 breaths/min 8.69 28.82 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15581 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.36 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15286 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 134.35 mmHg 4.77 13.5 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14411 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 49 130.29 breaths/min 3.56 24.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14858 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14900 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.43 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14905 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13645 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 172.87 % 8.4 29.11 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14145 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 159.89 % 9.61 37.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13733 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.9 % 17.25 51.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14037 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 138.45 % 8.14 31.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53750 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 109.53 % 2.79 19.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53886 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20114 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.66 degrees C 0.13 0.38 digital rectal thermometry Moms and pups used in studies were fed Dyets 19574 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 8 -0.26 degrees C 0.28 0.8 digital rectal thermometry Moms and pups used in studies were fed Dyets 19579 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 16 -6.89 mmHg 0.45 1.81 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19653 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 152.3 breaths/min 10.08 30.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17689 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.15 degrees C 0.16 0.54 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17723 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 -50.36 mmHg 4.55 13.65 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17936 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during7-9 min hypoxia/control during standard conditions 154.66 % 8.19 28.38 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18373 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 39.71 ml/min 1.83 12.81 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18726 381
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 7 0.24 mg/dl 0.03 0.08 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37069 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 18.9 pg 0.08 0.22 automated blood cell counting method Moms and pups used in studies were fed Dyets 37072 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 18.83 pg 0.09 0.23 automated blood cell counting method Moms and pups used in studies were fed Dyets 37075 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 18 70.17 mg/dl 2.03 8.62 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37149 401
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 7 9.19 mg/dl 0.12 0.33 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37293 401
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 420.82 beats/min 18.01 59.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17506 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 30.27 mmHg 0.64 1.42 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18166 381
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 17 127.0 g 8.9 36.8 whole body digital scale Moms and pups used in studies were fed Teklad 49532 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 7 13.77 % 4.64 12.29 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49628 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 7 42.43 mmHg 3.78 10.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49797 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 54.4 mmHg 9.24 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49821 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 1379.23 s 73.12 163.5 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50099 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 48 1204.79 s 33.56 232.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50289 461
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 49 57.32 fl 0.3 2.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 38808 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 7 22.0 mmol/l 0.98 2.58 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39087 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 51 110.27 mmol/l 0.58 4.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39180 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 16 9.28 x 10E6 cells/ul 0.14 0.56 automated blood cell counting method Moms and pups used in studies were fed Teklad 39289 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 7 186.71 mg/dl 29.64 78.41 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39324 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 17.99 g/dl 0.28 0.75 automated blood cell counting method Moms and pups used in studies were fed Dyets 39474 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 49 0.25 x 1000 cells/ul 0.02 0.16 automated blood cell counting method Moms and pups used in studies were fed Teklad 39737 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 16 0.38 x 1000 cells/ul 0.08 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 43276 401
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 111.46 % 4.4 14.59 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53575 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 112.07 % 7.16 22.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53732 381
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 7 0.4 mg/dl 0.02 0.06 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 40381 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.23 mmHg x min x kg x ml-1 0.02 0.06 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59032 526
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 31.97 g/dl 0.12 0.33 automated blood cell counting method Moms and pups used in studies were fed Dyets 40533 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 50 61.3 U/l 3.07 21.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40777 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 49 9.31 mg/dl 0.26 1.85 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37657 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 49 5.31 x 1000 cells/ul 0.32 2.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 40989 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 7 4.95 x 1000 cells/ul 0.57 1.52 automated blood cell counting method Moms and pups used in studies were fed Dyets 41145 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 7 58.43 U/l 8.37 22.16 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41155 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 54 0.17 mmHg x min x kg x ml-1 0.0 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59610 526
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 64 1.54 g/kg 0.01 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59720 526
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 9.52 x 10E6 cells/ul 0.16 0.41 automated blood cell counting method Moms and pups used in studies were fed Dyets 37916 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 47 17.74 g/dl 0.17 1.15 automated blood cell counting method Moms and pups used in studies were fed Teklad 38031 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 16 3.07 x 1000 cells/ul 0.43 1.71 automated blood cell counting method Moms and pups used in studies were fed Teklad 41555 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 56.0 % 0.88 2.34 automated blood cell counting method Moms and pups used in studies were fed Dyets 38355 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 7 109.14 mmol/l 0.8 2.12 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38410 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 7 105.29 mmol/l 0.68 1.8 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38413 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 16 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41699 401
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 44 54.15 mmHg 1.95 12.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46479 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 6 320.02 beats/min 37.3 91.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46516 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 5 53.8 mmHg 9.11 20.36 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47566 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 41 117.07 mmHg 3.07 19.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48686 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 25.24 % 8.35 18.67 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48712 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 84.63 % 2.95 11.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48807 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 938.97 s 47.32 125.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48923 461
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 10.38 ml/min/kg 0.62 2.07 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57650 526
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 53 13.26 ml/min/kg 0.46 3.37 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57661 526
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 48 36.9 degrees C 0.13 0.9 digital rectal thermometry Moms and pups used in studies were fed Teklad 16636 381
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.43 null 0.05 0.18 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58165 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 51 0.53 null 0.04 0.28 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58176 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 3 6.85 mg/kg 0.94 1.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58603 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 7 230.7 g 10.0 26.4 whole body digital scale Moms and pups used in studies were fed Dyets 58822 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 7 0.46 null 0.02 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58889 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 51 3.06 mg/kg 0.29 2.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58969 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 1.09 null 0.12 0.2 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60090 526
FHH/EurMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 60 7.26 g/kg 0.19 1.44 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45649 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 122.53 mmHg 4.73 17.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45780 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 42 122.34 mmHg 2.99 19.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45791 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 15 12.01 ml/min/g 0.67 2.61 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46704 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 152.8 mmHg 8.32 18.59 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45866 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 77.49 % 7.64 17.08 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45925 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 66.25 % 3.81 8.53 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48003 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 47.86 % 4.55 10.18 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47173 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 6.21 mmHg 0.14 0.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47248 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 184.12 beats/min 23.58 52.73 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45078 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 5 225.17 beats/min 14.97 33.48 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45080 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 5 5.24 IU/g 1.89 4.22 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45115 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 6 11.17 ml/min/g 1.07 2.63 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46285 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 47 5.45 mmHg 0.12 0.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47259 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 383.18 beats/min 58.34 154.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45252 461
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 129.83 breaths/min 11.4 39.49 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15585 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 126.12 mmHg 5.73 14.04 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14415 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.46 ml 0.05 0.18 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14623 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.42 ml 0.02 0.07 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14627 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.47 ml 0.04 0.14 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14631 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 125.82 mmHg 3.56 10.69 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14667 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 109.41 mmHg 4.87 16.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14333 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 18 123.86 mmHg 3.79 16.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14351 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 16 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17069 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 16 29.09 mmHg 0.6 2.4 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17261 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 0.3 ml 0.01 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13987 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 16 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19805 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 57.94 ml/min 5.35 18.53 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20126 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 50.99 mmHg 1.52 4.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19550 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 46.04 mmHg 0.7 1.97 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19555 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17606 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 130.54 % 9.23 29.17 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17914 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 135.33 % 11.27 33.81 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17919 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 420.82 beats/min 24.13 72.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18102 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 431.68 beats/min 10.13 30.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18107 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17051 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 55.18 mmHg 0.83 1.86 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18973 381
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 50 390.88 U/l 9.22 65.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36442 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 50 5.36 g/dl 0.07 0.51 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37025 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 7 19.43 mmol/l 2.07 5.47 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37049 401
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 19 402.94 beats/min 12.75 55.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17524 381
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 50 9.28 mg/dl 0.08 0.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36687 401
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 4 -8.16 mmHg 2.47 4.94 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19328 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 -42.13 mmHg 3.04 9.6 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19466 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 112.83 breaths/min 6.95 23.04 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18147 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 141.81 breaths/min 13.13 45.47 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18151 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 29.33 mmHg 1.22 2.11 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18170 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.02 degrees C 0.1 0.3 digital rectal thermometry Moms and pups used in studies were fed Dyets 18230 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 51.66 mmHg 1.26 3.98 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20478 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 0.07 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20539 381
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 14 6.49 % 2.33 8.7 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49749 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 14 34.29 mmHg 2.76 10.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50048 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 48 33.83 mmHg 1.68 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50059 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 5 0.31 IU/g 0.04 0.09 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50091 461
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 16 57.06 fl 0.28 1.12 automated blood cell counting method Moms and pups used in studies were fed Teklad 38797 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 7 6.6 mmol/l 0.41 1.09 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 38829 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 5.73 mmol/l 0.33 0.88 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 38832 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 18 16.17 mmol/l 0.75 3.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42114 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 7 5.4 g/dl 0.12 0.32 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42194 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 7 8.6 mg/dl 0.39 1.02 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42317 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 7 9.74 mg/dl 0.32 0.84 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42320 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 7 222.57 mg/dl 15.07 39.88 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39321 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 18.71 g/dl 0.64 1.69 automated blood cell counting method Moms and pups used in studies were fed Dyets 39477 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 7 1.21 x 1000 cells/ul 0.31 0.82 automated blood cell counting method Moms and pups used in studies were fed Dyets 42750 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 7 1.69 g/dl 0.06 0.16 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39964 401
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 111.16 % 8.05 25.47 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54563 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 111.38 % 4.21 14.59 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53578 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 139.48 % 6.01 20.81 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53594 381
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 8 0.49 null 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58886 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 20 165.3 g 2.4 10.9 whole body digital scale Moms and pups used in studies were fed Teklad 59114 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 64 185.3 g 5.2 41.2 whole body digital scale Moms and pups used in studies were fed Teklad 59125 526
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 18 52.56 U/l 3.75 15.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40766 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 46 55.29 % 0.42 2.83 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59320 526
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 7.85 mg/dl 0.36 1.47 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37646 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 7 24.0 mg/dl 0.82 2.16 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41384 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 18 19.89 mmol/l 1.23 5.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38313 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 51 19.69 mmol/l 0.49 3.47 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38324 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 49 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41710 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 18 152.78 mg/dl 5.46 23.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38582 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 48 149.63 mg/dl 2.92 20.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38593 401
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 5 1151.06 s 61.18 136.81 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45389 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 17 0.98 g 0.05 0.22 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45456 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 6 349.16 beats/min 39.15 95.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46512 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 49 0.27 IU/g 0.02 0.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47476 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 6.14 mmHg 0.8 2.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47537 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 15 230.48 beats/min 12.06 46.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47633 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 117.36 mmHg 4.86 16.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48675 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 137.71 mmHg 7.66 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48732 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 1096.9 s 77.69 205.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48927 461
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 53 20.85 ml/min/kg 1.06 7.71 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57863 526
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 34.35 ml/min/kg 3.54 11.73 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58051 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 8 204.8 g 6.7 18.9 whole body digital scale Moms and pups used in studies were fed Dyets 58819 526
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 7 1.71 IU/g 1.07 2.83 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45695 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 5 2.98 IU/g 1.84 4.11 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45709 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 7 761.08 s 60.27 159.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45839 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 5 234.91 beats/min 11.76 26.29 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45871 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 5 14.34 % 2.21 4.94 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48000 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 5 3.59 ml/min/g 0.36 0.81 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44902 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 150.73 % 36.24 95.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46036 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 15 post-ischemic value/pre-ischemic value x 100% 29.06 % 3.05 11.8 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47128 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 47 post-ischemic value/pre-ischemic value x 100% 44.87 % 2.27 15.58 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47139 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 30.69 % 5.02 13.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48131 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 5 6.29 ml/min/g 0.78 1.75 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45094 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 7 4.46 ml/min/g 0.36 0.94 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45098 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 5 4.61 IU/g 1.58 3.53 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45117 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 7 10.32 ml/min/g 0.4 1.05 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46289 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 45 post-ischemic value/pre-ischemic value x 100% 92.48 % 7.69 51.6 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48357 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 13 147.76 beats/min 12.14 43.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45199 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 40.6 mmHg 11.99 26.8 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45246 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 306.93 beats/min 30.38 80.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45248 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 40.02 mmHg 8.66 32.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45321 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 143.57 mmHg 7.4 19.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45373 461
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 0.29 ml 0.01 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15297 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.4 ml 0.02 0.07 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14619 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.44 ml 0.04 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13650 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.45 degrees C 0.14 0.48 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14131 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 0.36 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13976 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 105.11 % 3.3 23.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53987 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 -8.18 mmHg 0.79 2.51 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19635 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17611 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.25 degrees C 0.14 0.47 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17719 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 -50.89 mmHg 2.79 7.89 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17941 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 114.91 breaths/min 5.08 19.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18318 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 431.15 beats/min 29.19 71.49 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18759 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18789 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 57.47 mmHg 5.33 9.23 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18977 381
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 7 136.29 mmol/l 0.78 2.06 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36335 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 7 137.71 mmol/l 0.61 1.6 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36338 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 18 5.37 g/dl 0.08 0.33 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37014 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 50 76.3 mg/dl 1.7 12.01 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37160 401
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 -41.67 mmHg 7.22 12.51 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18644 381
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 7 94.71 mg/dl 5.0 13.24 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36708 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 7 84.71 mg/dl 4.64 12.28 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36711 401
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 16 -46.33 mmHg 4.5 18.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19484 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 8 36.63 degrees C 0.18 0.52 digital rectal thermometry Moms and pups used in studies were fed Dyets 18235 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 48 0.09 degrees C 0.16 1.11 digital rectal thermometry Moms and pups used in studies were fed Teklad 20373 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 16 51.87 mmHg 1.3 5.22 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20496 381
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 95.0 mmHg 6.2 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49159 461
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 60 140.1 g 5.5 42.2 whole body digital scale Moms and pups used in studies were fed Teklad 49551 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 7 10.42 % 3.58 9.47 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49632 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 0.37 IU/g 0.07 0.18 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 49680 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 62.2 mmHg 6.18 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49819 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 44 92.22 mmHg 2.74 18.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49950 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 5 1453.88 s 54.23 121.26 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50101 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 15 1229.89 s 43.51 168.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50278 461
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 51 18.31 mmol/l 0.54 3.88 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42125 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 7 3.6 g/dl 0.07 0.19 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42397 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 47 9.69 x 10E6 cells/ul 0.09 0.63 automated blood cell counting method Moms and pups used in studies were fed Teklad 39300 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 18 141.33 mmol/l 0.86 3.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39440 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 7 0.96 x 1000 cells/ul 0.2 0.52 automated blood cell counting method Moms and pups used in studies were fed Dyets 42753 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 18 96.89 U/l 4.74 20.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42822 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 51 105.61 U/l 4.06 28.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42833 401
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 140.58 % 6.55 25.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54323 381
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 49 31.91 g/dl 0.07 0.52 automated blood cell counting method Moms and pups used in studies were fed Teklad 39840 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 7 1.8 g/dl 0.07 0.18 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39967 401
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 119.75 % 7.07 22.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53551 381
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 7 146.0 U/l 28.35 75.0 standard blood chemistry panel Moms and pups used in studies were fed Dyets 43412 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 7 138.0 U/l 35.86 94.88 standard blood chemistry panel Moms and pups used in studies were fed Dyets 43415 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 5 0.23 mmHg x min x kg x ml-1 0.02 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59035 526
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 18 1.76 g/dl 0.04 0.17 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40602 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 18 21.5 mg/dl 0.78 3.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40880 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 16 3.71 x 1000 cells/ul 0.51 2.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 40978 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 7 2.34 x 1000 cells/ul 0.3 0.8 automated blood cell counting method Moms and pups used in studies were fed Dyets 41142 401
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59599 526
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 9.92 x 10E6 cells/ul 0.3 0.79 automated blood cell counting method Moms and pups used in studies were fed Dyets 37919 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 17.0 g/dl 0.3 1.18 automated blood cell counting method Moms and pups used in studies were fed Teklad 38020 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 7 3.83 x 1000 cells/ul 0.51 1.36 automated blood cell counting method Moms and pups used in studies were fed Dyets 41483 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 49 4.14 x 1000 cells/ul 0.26 1.8 automated blood cell counting method Moms and pups used in studies were fed Teklad 41566 401
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 42.99 % 2.18 5.76 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47517 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 98.29 mmHg 6.85 18.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48724 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 135.29 mmHg 10.69 28.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48736 461
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 14 36.63 degrees C 0.26 0.96 digital rectal thermometry Moms and pups used in studies were fed Teklad 16625 381
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 52 43.96 ml/min/kg 2.44 17.56 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58062 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 7 56.0 % 0.88 2.34 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 58199 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 58.54 % 1.94 5.14 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 58202 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 64 0.43 null 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58796 526
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 63.83 ml/min 4.33 14.99 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17472 381
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 40.86 mmHg 5.98 15.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45686 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 50 10.18 ml/min/g 0.32 2.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46715 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 7 1.54 g 0.06 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 45831 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 91.06 % 7.2 16.09 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45927 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 5 15.32 % 6.67 14.91 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47998 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 43.17 % 6.93 15.49 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47171 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 43 223.63 beats/min 17.45 114.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45210 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 44 38.03 mmHg 2.76 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45332 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 6 10.58 IU/g 3.03 7.41 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45365 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 5 1.52 g 0.08 0.17 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45382 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 5 1007.72 s 59.97 134.11 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45387 461
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 144.25 breaths/min 8.62 27.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15372 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 138.24 breaths/min 8.02 24.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15377 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 113.88 mmHg 7.4 22.19 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14662 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 15 113.45 breaths/min 6.73 26.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14847 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 156.95 % 10.95 36.31 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14141 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 10 28.32 mmHg 0.61 1.93 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17243 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19787 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 59.1 ml/min 5.55 16.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20705 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 113.88 % 4.92 19.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53882 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 116.27 % 4.95 19.18 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53983 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 7.54 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20118 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 -8.56 mmHg 0.38 1.14 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17708 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 49 133.43 breaths/min 3.84 26.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18329 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during7-9 min hypoxia/control during standard conditions 156.96 % 15.53 51.5 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18369 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 466.65 beats/min 11.1 31.39 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18755 381
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 18 268.28 U/l 12.37 52.5 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36431 401
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 7 9.41 mg/dl 0.17 0.45 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37296 401
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 4 -46.41 mmHg 2.24 4.48 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18640 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 41.82 ml/min 3.95 15.31 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18715 381
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 7 337.43 U/l 18.28 48.37 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36734 401
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 -7.0 mmHg 3.86 6.68 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19332 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 37.21 ml/min 1.74 12.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20272 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20544 381
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 15 1006.31 s 59.16 229.13 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49350 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 49 6.87 % 0.99 6.91 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49760 461
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 7 5.27 g/dl 0.16 0.42 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42191 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 47 55.55 % 0.52 3.59 automated blood cell counting method Moms and pups used in studies were fed Teklad 39054 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 18 110.11 mmol/l 0.59 2.49 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39169 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 49 18.29 pg 0.1 0.69 automated blood cell counting method Moms and pups used in studies were fed Teklad 42608 401
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 18 0.31 mg/dl 0.02 0.1 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39628 401
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 116.53 % 3.75 12.43 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54305 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 115.73 % 5.36 18.56 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54308 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 49 123.2 % 3.15 22.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54327 381
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 32.08 g/dl 0.08 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 39829 401
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 118.99 % 5.87 18.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54551 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 111.2 % 8.37 25.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54554 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 151.92 % 8.03 27.8 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53540 381
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 8 1.31 g/kg 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58874 526
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 136.94 % 11.45 34.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53735 381
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 7 0.43 mg/dl 0.04 0.1 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 40378 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 7 0.48 x 1000 cells/ul 0.13 0.34 automated blood cell counting method Moms and pups used in studies were fed Dyets 40387 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 7 0.19 x 1000 cells/ul 0.06 0.16 automated blood cell counting method Moms and pups used in studies were fed Dyets 40384 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 32.13 g/dl 0.1 0.27 automated blood cell counting method Moms and pups used in studies were fed Dyets 40530 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 50 1.7 g/dl 0.05 0.35 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40613 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 16 52.99 % 0.9 3.61 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59309 526
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 22.13 ml/min/kg 2.51 7.09 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59750 526
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 7 32.29 mg/dl 1.51 3.99 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41381 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 43 5.28 mmol/l 0.1 0.65 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38129 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 7 58.96 fl 0.34 0.91 automated blood cell counting method Moms and pups used in studies were fed Dyets 38168 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 7 0.09 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Dyets 38197 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 7 0.08 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms and pups used in studies were fed Dyets 38200 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 7 6.47 x 1000 cells/ul 0.82 2.17 automated blood cell counting method Moms and pups used in studies were fed Dyets 41486 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 58.54 % 1.94 5.14 automated blood cell counting method Moms and pups used in studies were fed Dyets 38358 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 18 0.18 mg/dl 0.02 0.09 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41920 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 51 0.13 mg/dl 0.01 0.07 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41931 401
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 60 1.0 g 0.04 0.31 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45467 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 5.86 mmHg 0.7 1.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47533 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 5 44.6 mmHg 4.59 10.26 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47564 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 66.8 % 5.74 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48504 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 21.53 % 4.31 9.63 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48710 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 93.29 mmHg 8.38 22.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48728 461
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 11.08 ml/min/kg 2.42 4.18 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57571 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 5 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 57759 526
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 27.86 mmHg 0.76 2.28 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16448 381
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 13.1 ml/min/kg 0.52 1.72 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57852 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 20 0.33 null 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58785 526
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 32.0 mmHg 7.47 19.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45690 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 5 8.54 ml/min/g 0.65 1.45 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46635 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 5 7.62 ml/min/g 0.77 1.73 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46637 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 7 1.46 g 0.05 0.14 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 45827 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 7 611.92 s 56.78 150.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45835 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 38 17.04 IU/g 1.18 7.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45990 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 14 3.64 ml/min/g 0.36 1.35 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44769 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 48 4.68 ml/min/g 0.24 1.68 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44780 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 5 3.68 ml/min/g 0.63 1.4 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44900 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 113.74 % 29.64 78.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46032 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 60.29 mmHg 2.65 7.02 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45055 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 61.29 mmHg 5.44 14.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45059 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 15 0.12 IU/g 0.04 0.14 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47459 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 32.2 mmHg 5.63 12.6 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45244 461
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 -0.34 degrees C 0.14 0.49 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14135 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 49 %change=VE during 2-3 min hypoxia/control during standard conditions 133.12 % 3.59 25.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13744 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 131.09 % 6.07 19.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14032 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 57.86 ml/min 2.51 7.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20700 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 49 121.35 % 3.9 27.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53754 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 46.57 ml/min 3.14 10.4 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20122 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 145.7 breaths/min 8.4 26.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17684 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -7.59 mmHg 1.29 3.64 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17713 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 58.76 ml/min 2.75 8.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18068 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 65.09 ml/min 5.58 16.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18073 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 4 0.03 null 0.03 0.06 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18785 381
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 7 11.71 mmol/l 1.11 2.93 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37046 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 7 0.23 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37066 401
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 18 9.04 mg/dl 0.09 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36676 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 7 408.57 U/l 19.44 51.43 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36737 401
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 15 41.29 ml/min 3.2 12.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20261 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 14 -0.61 degrees C 0.22 0.82 digital rectal thermometry Moms and pups used in studies were fed Teklad 20362 381
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 104.4 mmHg 6.24 13.96 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49157 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 48 978.1 s 33.1 229.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49361 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 7 0.35 IU/g 0.06 0.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 49676 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 7 50.14 mmHg 4.97 13.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49793 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 102.61 mmHg 5.43 20.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49939 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 5 0.31 IU/g 0.1 0.23 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50093 461
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 16 52.99 % 0.9 3.61 automated blood cell counting method Moms and pups used in studies were fed Teklad 39043 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 7 18.71 mmol/l 1.6 4.23 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39090 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 18 3.61 g/dl 0.07 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42285 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 50 3.66 g/dl 0.05 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42296 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 7 3.59 g/dl 0.11 0.3 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42394 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 16 18.3 pg 0.11 0.45 automated blood cell counting method Moms and pups used in studies were fed Teklad 42597 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 51 142.63 mmol/l 0.47 3.35 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39451 401
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 51 0.33 mg/dl 0.01 0.09 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39639 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 16 0.22 x 1000 cells/ul 0.05 0.19 automated blood cell counting method Moms and pups used in studies were fed Teklad 39726 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 49 0.88 x 1000 cells/ul 0.1 0.72 automated blood cell counting method Moms and pups used in studies were fed Teklad 43287 401
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 123.05 % 8.43 25.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54566 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 134.27 % 7.41 24.57 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53537 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 112.41 % 9.21 27.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53554 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 140.04 % 11.02 36.55 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53591 381
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 19 4.0 mg/kg 1.04 4.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58958 526
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 51 24.51 mg/dl 0.7 5.03 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40891 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 7 63.0 U/l 16.41 43.42 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41158 401
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 20 1.88 g/kg 0.04 0.17 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59709 526
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 5 15.82 ml/min/kg 2.38 5.33 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59753 526
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 17 4.69 mmol/l 0.15 0.61 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38118 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 7 58.81 fl 0.27 0.71 automated blood cell counting method Moms and pups used in studies were fed Dyets 38165 401
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 58.59 mmHg 4.4 16.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46468 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 47.87 % 9.4 24.86 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47513 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 50 235.28 beats/min 4.68 33.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47644 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 69.19 % 5.13 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48500 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 32.96 % 6.26 23.41 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48578 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 39 post-ischemic value/pre-ischemic value x 100% 33.93 % 2.79 17.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48589 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 42 post-ischemic value/pre-ischemic value x 100% 78.72 % 2.67 17.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48818 461
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 11.82 ml/min/kg 0.95 2.68 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57568 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 16.98 ml/min/kg 1.54 4.37 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57712 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 14.05 ml/min/kg 0.89 1.54 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57715 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 6 0.03 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 57756 526
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 30.04 mmHg 0.46 1.3 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16453 381
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 11 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58541 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 54 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58552 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 3 5.76 mg/kg 2.11 3.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58600 526
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 6 1.32 g/kg 0.07 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58877 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.81 null 0.09 0.24 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60087 526
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 47.43 ml/min 3.32 11.01 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17468 381
FHH/EurMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 17 8.05 g/kg 0.41 1.71 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45630 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 158.4 mmHg 7.97 17.83 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45813 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 173.2 mmHg 14.01 31.33 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45815 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 167.6 mmHg 14.06 31.44 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45868 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 5 250.62 beats/min 16.49 36.87 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45873 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 5 post-ischemic value/pre-ischemic value x 100% 56.18 % 5.69 12.73 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48005 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 post-ischemic value/pre-ischemic value x 100% 23.52 % 4.91 13.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48135 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 5 5.6 mmHg 0.51 1.14 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47376 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 5 5.6 mmHg 0.51 1.14 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47378 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 post-ischemic value/pre-ischemic value x 100% 64.18 % 8.58 32.11 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48346 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 13.17 IU/g 2.67 6.54 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45369 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 7 141.43 mmHg 10.28 27.21 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45377 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 5 1.94 g 0.15 0.34 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45384 461