Phenominer Database Results (168 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.28 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13929 381
FHH-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 29.99 mmHg 0.74 1.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17257 381
FHH-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.03 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19797 381
FHH-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19801 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 104.26 % 6.56 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53997 381
FHH-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.94 mg/dl 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36630 401
FHH-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.73 degrees C 0.24 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20318 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -49.48 mmHg 4.51 7.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19476 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 35.73 ml/min 3.8 10.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20217 381
FHH-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.4 mmol/l 0.87 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39394 401
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 124.66 % 4.58 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54333 381
FHH-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.26 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39582 401
FHH-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39585 401
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 51.14 % 0.58 1.85 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59266 526
FHH-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 7.39 x 1000 cells/ul 0.36 1.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40935 401
FHH-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 43.4 U/l 1.94 6.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40723 401
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 245.4 beats/min 4.61 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47591 461
FHH-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 47.32 % 5.61 16.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48533 461
FHH-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 47.6 % 4.84 14.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48536 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.32 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47472 461
FHH-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 140.4 mg/dl 4.65 14.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38539 401
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 21.73 ml/min/kg 1.03 3.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57806 526
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 17.42 ml/min/kg 0.27 0.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57607 526
FHH-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.04 degrees C 0.21 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16578 381
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.53 ml/min/g 0.91 2.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46659 461
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.44 mmHg 0.25 0.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47203 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 56.64 mmHg 4.95 14.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45279 461
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 148.7 g 7.2 22.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49545 461
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 133.84 breaths/min 4.86 14.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14800 381
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 119.24 % 5.44 17.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53760 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 116.72 % 5.29 14.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53896 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.63 mmHg 1.0 2.63 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19649 381
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 358.54 beats/min 27.09 60.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17516 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 38.76 ml/min 1.82 5.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18668 381
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 137.36 breaths/min 4.44 13.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18271 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 37.17 ml/min 1.82 5.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20214 381
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 105.6 mmHg 2.82 8.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49897 461
FHH-Chr 20BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 977.4 s 34.87 110.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49305 461
FHH-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 16.6 mmol/l 0.78 2.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42068 401
FHH-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 141.5 mmol/l 0.79 2.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39397 401
FHH-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.2 U/l 2.66 8.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42779 401
FHH-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.96 x 10E6 cells/ul 0.81 2.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39243 401
FHH-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.59 x 10E6 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39246 401
FHH-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.27 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39683 401
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.05 mg/kg 0.17 0.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58915 526
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 193.2 g 4.2 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59068 526
FHH-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 55.1 U/l 2.98 9.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40720 401
FHH-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59553 526
FHH-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.51 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59663 526
FHH-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.66 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59666 526
FHH-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.62 mmol/l 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38072 401
FHH-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 6.05 x 1000 cells/ul 0.33 1.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41512 401
FHH-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 19.9 mmol/l 0.5 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38270 401
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 26.25 ml/min/kg 1.45 4.58 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57809 526
FHH-Chr 20BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 84.71 % 3.58 10.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48765 461
FHH-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.43 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58119 526
FHH-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.6 null 0.05 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58739 526
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 35.61 % 2.71 8.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47086 461
FHH-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 114.28 mmHg 6.39 14.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14343 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.28 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15239 381
FHH-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.51 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36971 401
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 149.0 breaths/min 16.24 45.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14803 381
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 4.89 mmHg 0.29 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47206 461
FHH-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.93 g/kg 0.43 1.35 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45643 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.32 ml/min/g 0.28 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44727 461
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 48.96 mmHg 3.32 9.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46426 461
FHH-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.43 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40559 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.9 pg 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42554 401
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 114.4 % 8.7 26.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53892 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.34 % 8.03 24.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53993 381
FHH-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 69.2 mg/dl 1.37 4.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37103 401
FHH-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 6.05 % 0.89 2.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49707 461
FHH-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1197.0 s 39.77 125.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50233 461
FHH-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 38.44 mmHg 2.69 8.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50006 461
FHH-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.3 mmol/l 0.76 2.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39126 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 29.73 g/dl 2.34 7.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39783 401
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.66 mg/kg 0.28 0.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58912 526
FHH-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.55 mg/dl 0.15 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37600 401
FHH-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.8 mg/dl 0.88 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40834 401
FHH-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.03 x 1000 cells/ul 0.94 2.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40932 401
FHH-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.11 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41656 401
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 18.88 IU/g 1.15 3.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45987 461
FHH-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.6 % 3.88 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48304 461
FHH-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 405.9 U/l 10.71 33.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36385 401
FHH-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 266.9 U/l 5.05 15.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36388 401
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 187.11 beats/min 10.69 32.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45154 461
FHH-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.09 g/kg 0.19 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45645 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 20.03 IU/g 3.07 9.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45984 461
FHH-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 7.45 % 1.65 4.68 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49704 461
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 148.3 g 2.9 9.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49547 461
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 217.63 beats/min 20.74 65.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47588 461
FHH-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.52 null 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58742 526
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.07 pg 1.32 4.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42551 401
FHH-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 116.3 mmHg 4.26 11.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14347 381
FHH-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 66.4 mg/dl 1.53 4.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37106 401
FHH-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 143.06 % 12.34 37.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13686 381
FHH-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 149.2 % 4.58 12.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13689 381
FHH-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17065 381
FHH-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.83 mg/dl 0.09 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36633 401
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 146.72 breaths/min 16.37 46.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18274 381
FHH-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 55.0 mmHg 2.89 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20488 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -41.8 mmHg 3.3 8.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19480 381
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.07 % 0.71 2.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38997 401
FHH-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 4.02 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42239 401
FHH-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.0 mmol/l 0.68 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39123 401
FHH-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 54.51 fl 3.97 12.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38751 401
FHH-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.55 fl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38754 401
FHH-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 90.8 U/l 3.09 9.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42776 401
FHH-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.38 x 1000 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39680 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.75 g/dl 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39786 401
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.07 % 0.71 2.25 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59263 526
FHH-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 18.9 mg/dl 0.59 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40837 401
FHH-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.06 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41653 401
FHH-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.6 mmol/l 0.52 1.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38267 401
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 121.05 mmHg 4.97 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48633 461
FHH-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.03 g 0.07 0.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45411 461
FHH-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 1.05 g 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45414 461
FHH-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.89 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16581 381
FHH-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 52.28 ml/min/kg 3.39 10.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58005 526
FHH-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 58.25 ml/min/kg 2.6 8.23 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58008 526
FHH-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.46 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58122 526
FHH-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58495 526
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 192.48 beats/min 9.16 27.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45157 461
FHH-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 112.41 % 29.28 87.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48301 461
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 132.74 % 8.34 23.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53764 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -2.03 mmHg 3.08 5.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19645 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.24 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15242 381
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.31 % 4.08 12.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47083 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 58.25 mmHg 7.17 21.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45276 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.26 ml/min/g 0.48 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46662 461
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 104.04 mmHg 3.81 11.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49894 461
FHH-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 31.3 mmHg 3.08 9.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50003 461
FHH-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.49 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40556 401
FHH-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.85 g/dl 3.68 11.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37974 401
FHH-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.25 g/dl 0.16 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37977 401
FHH-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 4 31.59 mmHg 2.26 4.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17253 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13932 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 38.71 ml/min 3.64 10.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18671 381
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 368.52 beats/min 21.37 56.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17520 381
FHH-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 55.26 mmHg 2.42 6.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20492 381
FHH-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 -0.43 degrees C 0.22 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20315 381
FHH-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1165.78 s 51.59 154.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50236 461
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 51.14 % 0.58 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39000 401
FHH-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.08 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42242 401
FHH-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 17.5 mmol/l 0.64 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42071 401
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 129.01 % 5.06 14.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54337 381
FHH-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.88 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43230 401
FHH-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.97 x 1000 cells/ul 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43233 401
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 162.0 g 3.9 12.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59071 526
FHH-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.2 mg/dl 0.2 0.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37603 401
FHH-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.18 mmol/l 0.14 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38075 401
FHH-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.51 x 1000 cells/ul 0.56 1.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41509 401
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.39 IU/g 0.07 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47470 461
FHH-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41877 401
FHH-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 156.8 mg/dl 5.62 17.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38536 401
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 15.18 ml/min/kg 0.59 1.86 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57604 526
FHH-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58498 526
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 128.38 mmHg 4.83 15.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45735 461
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 125.94 mmHg 4.99 14.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45738 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.28 ml/min/g 0.84 2.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44724 461
FHH-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.47 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17061 381
FHH-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.51 g/dl 0.05 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36968 401
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 45.79 mmHg 4.22 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46423 461
FHH-Chr 20BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 930.56 s 49.65 148.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49308 461
FHH-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41874 401
FHH-Chr 20BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 81.76 % 3.44 10.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48762 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 122.94 mmHg 4.72 14.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48630 461
FHH-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59556 526