Phenominer Database Results (214 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 103.98 breaths/min 4.03 11.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15379 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.31 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14906 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.25 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14003 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 109.62 % 4.44 21.31 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53996 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 -7.85 mmHg 1.78 6.16 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19676 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 112.83 breaths/min 4.01 12.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17690 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 123.13 % 6.51 18.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17921 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 449.47 beats/min 14.97 36.66 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18109 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 116.6 breaths/min 7.75 32.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18345 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 110.37 breaths/min 5.06 24.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18344 381
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 20 178.3 U/l 5.17 23.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36457 401
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 17 8.76 mg/dl 0.1 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36703 401
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 -40.3 mmHg 1.83 5.18 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19508 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 -43.74 mmHg 2.47 8.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19507 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 23.31 ml/min 1.35 5.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20288 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 -1.79 degrees C 0.22 0.94 digital rectal thermometry Moms and pups used in studies were fed Teklad 20389 381
BN/NHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 23 931.69 s 37.66 180.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49377 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 110.81 mmHg 3.12 15.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49965 461
BN/NHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 1126.09 s 23.27 113.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50304 461
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 54.18 % 0.53 1.91 automated blood cell counting method Moms and pups used in studies were fed Teklad 39070 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 18.26 pg 0.09 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 42624 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 15 0.18 x 1000 cells/ul 0.05 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 39752 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 123.27 % 3.81 18.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54336 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 102.19 % 5.96 16.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54550 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 107.62 % 6.63 18.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53550 381
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 15 1.01 x 1000 cells/ul 0.51 1.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 43302 401
BN/NHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 13 7.25 x 1000 cells/ul 0.39 1.4 automated blood cell counting method Moms and pups used in studies were fed Teklad 41005 401
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 28 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59625 526
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 32 1.34 g/kg 0.03 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59735 526
BN/NHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 15 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41725 401
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 19 0.78 IU/g 0.09 0.38 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47505 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 247.22 beats/min 10.24 50.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47659 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 128.16 mmHg 3.9 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48702 461
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 16.73 ml/min/kg 1.4 6.87 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57676 526
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 28.92 mmHg 1.0 1.73 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16454 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 35.56 degrees C 0.25 1.05 digital rectal thermometry Moms and pups used in studies were fed Teklad 16652 381
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 26 66.45 ml/min/kg 4.43 22.57 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58078 526
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 0.46 null 0.02 0.12 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58191 526
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 29 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58568 526
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 32 0.32 null 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58812 526
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 24 10.02 ml/min/g 0.75 3.69 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44795 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 227.28 beats/min 6.69 32.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45226 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 71.06 mmHg 3.3 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45347 461
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 99.09 mmHg 1.82 3.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14668 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 96.03 breaths/min 3.91 18.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14873 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.3 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13652 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 119.99 mmHg 5.02 18.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14374 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 29.44 ml/min 1.78 5.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20707 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 50.89 mmHg 1.79 4.72 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19557 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 -1.2 degrees C 0.27 0.76 digital rectal thermometry Moms and pups used in studies were fed Dyets 19581 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 116.03 breaths/min 8.65 24.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17691 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 -6.23 mmHg 1.02 1.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17714 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 -51.1 mmHg 2.72 7.19 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17943 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 -51.1 mmHg 6.77 11.73 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17942 381
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 20 62.0 mg/dl 1.05 4.69 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37175 401
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 273.08 beats/min 29.68 93.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17548 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 37.03 degrees C 0.2 0.56 digital rectal thermometry Moms and pups used in studies were fed Dyets 18237 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.05 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20546 381
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 24 6.26 % 2.01 9.87 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49775 461
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 17 16.53 mmol/l 0.56 2.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42141 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 20 144.75 mmol/l 0.42 1.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39466 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 17 101.29 U/l 8.24 33.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42849 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 17 0.25 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39655 401
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 13 0.95 x 1000 cells/ul 0.28 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 43303 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 19 2.97 mg/kg 0.71 3.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58985 526
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 32 133.1 g 1.3 7.3 whole body digital scale Moms and pups used in studies were fed Teklad 59141 526
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 17 47.94 U/l 5.69 23.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40793 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 20 55.49 % 0.42 1.89 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59335 526
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 17.83 g/dl 0.15 0.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 38046 401
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 20 23.8 mmol/l 0.48 2.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38339 401
BN/NHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 13 0.18 x 1000 cells/ul 0.05 0.18 automated blood cell counting method Moms and pups used in studies were fed Teklad 41726 401
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 23 0.59 g 0.02 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45483 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 21 32.91 mmHg 2.72 12.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46495 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 140.93 mmHg 3.2 15.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48701 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 76.24 % 3.86 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48834 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 post-ischemic value/pre-ischemic value x 100% 78.22 % 1.72 8.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48833 461
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 22.43 ml/min/kg 1.63 8.01 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57878 526
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 27 27.59 ml/min/kg 2.07 10.77 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57879 526
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 24 4.53 g/kg 0.1 0.48 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45678 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 11.48 IU/g 0.82 2.59 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45710 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 22 17.81 ml/min/g 0.68 3.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46730 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 23 post-ischemic value/pre-ischemic value x 100% 55.18 % 3.21 15.39 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47154 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 222.91 beats/min 8.17 40.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45225 461
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.23 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15313 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 12 31.45 mmHg 1.19 4.12 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17284 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 %change=VE during 2-3 min hypoxia/control during standard conditions 141.88 % 3.93 18.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13759 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 154.48 % 7.68 32.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13760 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 0.3 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14002 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 117.29 % 5.01 24.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53895 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 113.63 % 4.18 12.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17920 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 32.31 ml/min 1.43 6.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18741 381
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 20 5.76 g/dl 0.07 0.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37040 401
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 20 8.97 mg/dl 0.12 0.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36702 401
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 23 -1.64 degrees C 0.25 1.18 digital rectal thermometry Moms and pups used in studies were fed Teklad 20388 381
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 24 163.8 g 3.8 18.5 whole body digital scale Moms and pups used in studies were fed Teklad 49580 461
BN/NHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 23 33.83 mmHg 1.95 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50075 461
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 20 16.0 mmol/l 0.42 1.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42140 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 55.28 % 0.49 1.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 39069 401
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 17 3.62 g/dl 0.05 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42312 401
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 17 110.65 mmol/l 0.74 3.04 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39196 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 9.36 x 10E6 cells/ul 0.07 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 39315 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 20 95.1 U/l 6.0 26.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42848 401
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 32.17 g/dl 0.11 0.39 automated blood cell counting method Moms and pups used in studies were fed Teklad 39856 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 116.9 % 7.85 23.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54558 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 114.4 % 4.57 13.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53546 381
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 17 4.83 mmol/l 0.16 0.68 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38145 401
BN/NHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 17 171.94 mg/dl 6.33 26.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38609 401
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 39.16 mmHg 2.2 10.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46494 461
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 32 0.36 null 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58811 526
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 3 34.51 IU/g 7.7 13.34 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46012 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 5.45 mmHg 0.13 0.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47274 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 23 5.44 mmHg 0.17 0.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47275 461
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 107.96 breaths/min 5.4 16.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15378 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 95.6 mmHg 4.17 11.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14669 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.28 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14907 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 121.37 mmHg 4.32 13.66 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14375 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17092 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19827 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 107.67 % 2.68 12.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53763 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 -0.8 degrees C 0.23 0.7 digital rectal thermometry Moms and pups used in studies were fed Dyets 19580 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17613 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -7.15 mmHg 1.45 3.83 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17715 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 40.78 ml/min 3.23 9.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18074 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 349.4 beats/min 28.52 57.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18108 381
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 17 125.94 U/l 4.8 19.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36458 401
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 17 5.38 g/dl 0.1 0.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37041 401
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 26.3 ml/min 1.02 4.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20287 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20545 381
BN/NHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 24 875.85 s 23.17 113.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49376 461
BN/NHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 24 43.88 mmHg 2.21 10.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50074 461
BN/NHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 1201.4 s 34.75 166.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50305 461
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 13 56.81 fl 0.18 0.64 automated blood cell counting method Moms and pups used in studies were fed Teklad 38824 401
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 15 59.07 fl 0.23 0.88 automated blood cell counting method Moms and pups used in studies were fed Teklad 38823 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 9.54 x 10E6 cells/ul 0.11 0.41 automated blood cell counting method Moms and pups used in studies were fed Teklad 39316 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 19.07 pg 0.09 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 42623 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 17 143.82 mmol/l 0.52 2.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39467 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 20 0.24 mg/dl 0.01 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39654 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 134.12 % 8.01 33.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54338 381
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 32.27 g/dl 0.09 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 39855 401
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 99.83 % 5.2 15.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54546 381
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 32 189.6 g 2.5 14.3 whole body digital scale Moms and pups used in studies were fed Teklad 59140 526
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 20 47.55 U/l 3.11 13.92 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40792 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 17 54.05 % 0.45 1.85 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59336 526
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 20 8.04 mg/dl 0.17 0.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37672 401
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 7.92 mg/dl 0.2 0.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37673 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 17 24.0 mg/dl 0.92 3.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40907 401
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 32 1.57 g/kg 0.03 0.18 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59736 526
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 17.43 g/dl 0.15 0.56 automated blood cell counting method Moms and pups used in studies were fed Teklad 38047 401
BN/NHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 20 159.35 mg/dl 4.56 20.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38608 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 20 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41946 401
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 19 0.73 IU/g 0.06 0.28 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47506 461
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 27 20.64 ml/min/kg 1.27 6.61 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57677 526
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 27.08 mmHg 1.33 3.52 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16455 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 23 36.11 degrees C 0.21 1.0 digital rectal thermometry Moms and pups used in studies were fed Teklad 16651 381
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 28 49.29 ml/min/kg 3.1 16.42 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58077 526
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 28 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58567 526
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 146.43 mmHg 3.24 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45806 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 135.42 mmHg 3.67 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45807 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 4 40.49 IU/g 5.92 11.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46011 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 21 post-ischemic value/pre-ischemic value x 100% 57.27 % 3.35 15.34 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47155 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 post-ischemic value/pre-ischemic value x 100% 86.83 % 2.21 10.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48373 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 73.79 mmHg 3.69 17.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45348 461
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 0.28 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15312 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 103.25 breaths/min 4.73 20.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14874 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13651 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17091 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 8 31.77 mmHg 0.93 2.64 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17285 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 138.98 % 6.98 20.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14038 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 144.23 % 11.49 32.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14039 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19828 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 33.17 ml/min 1.96 5.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20706 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 119.67 % 6.41 27.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53765 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 118.59 % 6.31 26.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53897 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 106.19 % 3.96 16.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53998 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 48.85 mmHg 1.43 2.47 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19556 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 -7.76 mmHg 0.88 2.5 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19677 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 7.51 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17612 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 34.63 ml/min 3.33 9.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18075 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 28.92 ml/min 1.73 7.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18742 381
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 17 58.41 mg/dl 1.09 4.5 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37176 401
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 226.69 beats/min 13.62 49.11 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17547 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 36.54 degrees C 0.15 0.46 digital rectal thermometry Moms and pups used in studies were fed Dyets 18236 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 54.33 mmHg 1.8 6.25 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20519 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 53.58 mmHg 1.29 3.65 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20520 381
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 23 115.0 g 2.4 11.7 whole body digital scale Moms and pups used in studies were fed Teklad 49581 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 23 4.31 % 1.05 5.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49776 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 23 101.61 mmHg 5.04 24.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49966 461
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 20 3.65 g/dl 0.05 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42311 401
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 20 110.25 mmol/l 0.58 2.59 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39195 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 12 0.08 x 1000 cells/ul 0.04 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 39753 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 122.06 % 6.84 19.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54562 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 121.6 % 5.64 16.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53727 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 136.09 % 11.9 33.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53731 381
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 18 1.44 mg/kg 0.17 0.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58984 526
BN/NHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 20 2.11 g/dl 0.03 0.16 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40628 401
BN/NHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 17 1.75 g/dl 0.07 0.31 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40629 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 20 19.6 mg/dl 0.44 1.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40906 401
BN/NHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 15 6.44 x 1000 cells/ul 0.52 2.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41004 401
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 29 0.12 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59626 526
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 16 4.95 mmol/l 0.18 0.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38144 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 15 5.7 x 1000 cells/ul 0.53 2.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 41581 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 13 6.03 x 1000 cells/ul 0.42 1.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 41582 401
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 17 21.41 mmol/l 0.43 1.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38340 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 17 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41947 401
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 24 0.74 g 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45482 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 264.61 beats/min 9.44 45.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47660 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 55.29 % 3.87 18.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48605 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 52.63 % 2.7 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48604 461
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 24 0.42 null 0.03 0.15 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58192 526
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 23 5.16 g/kg 0.18 0.85 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45679 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 9.69 IU/g 0.76 2.4 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45711 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 21 16.32 ml/min/g 0.83 3.8 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46731 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 23 9.42 ml/min/g 0.62 2.95 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44796 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 post-ischemic value/pre-ischemic value x 100% 94.79 % 6.88 33.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48372 461