Phenominer Database Results (408 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 3BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 137.53 mmHg 5.6 13.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15098 381
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 -0.28 degrees C 0.25 0.83 digital rectal thermometry Moms and pups used in studies were fed Teklad 15726 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.35 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15290 381
SS-Chr 3BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 397.67 beats/min 15.63 34.96 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14703 381
SS-Chr 3BN/Mcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 444.24 beats/min 17.85 30.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14709 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 110.93 breaths/min 8.36 28.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14851 381
SS-Chr 3BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 9 1.14 mEq/d 0.14 0.41 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52947 482
SS-Chr 3BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 8 2.03 ml/min 0.32 0.9 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52161 482
SS-Chr 3BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 9 408.25 beats/min 5.72 17.16 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52651 482
SS-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 9 270.13 mg/d 50.71 152.12 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52700 482
SS-Chr 3BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 7 17.73 mEq/d 1.8 4.76 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52754 482
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 146.53 % 6.57 20.78 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54146 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 113.71 mmHg 1.64 2.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13496 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.36 ml 0.03 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13980 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.29 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13985 381
SS-Chr 3BN/Mcwi post-insult time to mammary tumor formation 7,12-dimethyltetraphene (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152.0 days-162.0 days 14 95.48 d 1.67 6.23 manual palpation method 0 DMBA oral gavage 105 days 200 mg DMBA in 10 ml seame oil 11491 86
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19790 381
SS-Chr 3BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 4 7.48 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20635 381
SS-Chr 3BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 12 226.5 g 7.5 25.8 whole body digital scale Moms and pups used in studies were fed Dyets 17874 381
SS-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.27 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18044 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 111.21 breaths/min 5.04 16.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18327 381
SS-Chr 3BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 10 4.35 x 1000 cells/ul 0.27 0.85 automated blood cell counting method Moms and pups used in studies were fed Teklad 36902 401
SS-Chr 3BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 5.47 g/dl 0.08 0.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37231 401
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 10 152.9 U/l 8.62 27.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37477 401
SS-Chr 3BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 10 142.9 mmol/l 0.62 1.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36517 401
SS-Chr 3BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 0.65 g 0.06 0.17 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49116 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 6.27 mmHg 0.34 0.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49233 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 78.92 mmHg 4.85 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49943 461
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 7 887.86 s 38.76 102.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50175 461
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 7 109.14 mmol/l 0.7 1.86 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39173 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 8.94 x 10E6 cells/ul 0.1 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 39293 401
SS-Chr 3BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 10 0.25 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42673 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 6 0.43 mg/dl 0.05 0.12 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39637 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 7 0.32 x 1000 cells/ul 0.04 0.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 39730 401
SS-Chr 3BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 10 0.16 mg/dl 0.02 0.07 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42910 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 32.47 g/dl 0.25 0.67 automated blood cell counting method Moms and pups used in studies were fed Teklad 39833 401
SS-Chr 3BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 10 4.89 x 1000 cells/ul 0.3 0.95 automated blood cell counting method Moms and pups used in studies were fed Teklad 39918 401
SS-Chr 3BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 10 102.4 mmol/l 0.45 1.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40033 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 18.32 pg 0.15 0.48 automated blood cell counting method Moms and pups used in studies were fed Teklad 40231 401
SS-Chr 3BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 4.0 g/dl 0.07 0.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40440 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 7 1.7 g/dl 0.03 0.08 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40606 401
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 9 1.02 mg/kg 0.22 0.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59191 526
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 7 48.07 % 1.54 4.06 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59318 526
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 7 9.56 mg/dl 0.38 1.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37650 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 7 7.23 x 1000 cells/ul 0.41 1.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 40982 401
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.19 g/kg 0.04 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59487 526
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 15 1.38 g/kg 0.04 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59713 526
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 7 5.47 mmol/l 0.24 0.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38122 401
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 6 4.32 mmol/l 0.27 0.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38127 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41703 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 7 138.29 mg/dl 1.87 4.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38586 401
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 75.34 mmHg 5.35 13.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45560 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 0.53 IU/g 0.08 0.23 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47462 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 257.14 beats/min 8.39 25.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47637 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 81.85 mmHg 6.08 19.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48684 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 86.88 % 6.39 19.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48811 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 96.28 % 4.53 13.6 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48816 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 14.3 IU/g 1.82 5.14 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 48880 461
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 13.43 ml/min/kg 0.72 2.38 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57654 526
SS-Chr 3BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 10 248.4 g 5.8 18.3 whole body digital scale Moms and pups used in studies were fed Teklad 55198 522
SS-Chr 3BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 178.4 g 3.3 10.5 whole body digital scale Moms and pups used in studies were fed Teklad 55204 522
SS-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 -6.99 null 0.08 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55293 522
SS-Chr 3BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.44 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16530 381
SS-Chr 3BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.43 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16535 381
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.27 degrees C 0.15 0.48 digital rectal thermometry Moms and pups used in studies were fed Teklad 16634 381
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 61.14 ml/min/kg 6.06 16.04 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58259 526
SS-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 37.43 degrees C 0.14 0.46 digital rectal thermometry Moms and pups used in studies were fed Teklad 16874 381
SS-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 0.91 E-7mole 0.17 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55912 522
SS-Chr 3BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 13 254.8 g 11.2 40.2 whole body digital scale Moms and pups used in studies were fed Teklad 58365 526
SS-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 0.11 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54692 522
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 12 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58550 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 15 0.43 null 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58789 526
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.11 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59915 526
SS-Chr 3BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.44 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17427 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 35.08 mmHg 1.16 2.32 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16073 381
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 5.33 ml/min/g 0.36 1.03 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44773 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 4.86 mmHg 0.41 1.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47252 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 4.33 ml/min/g 0.46 1.3 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46262 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 0.87 IU/g 0.07 0.21 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47325 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 75.14 % 6.28 18.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48467 461
SS-Chr 3BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 140.86 mmHg 7.28 16.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15104 381
SS-Chr 3BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 70.24 ml/min 2.98 9.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14562 381
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 8 0.45 mg/dl 0.04 0.1 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52210 482
SS-Chr 3BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 5 0.34 mg/dl 0.03 0.07 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52213 482
SS-Chr 3BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 5 420.97 beats/min 7.06 15.79 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52654 482
SS-Chr 3BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 9 20.07 mEq/d 2.22 6.67 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52751 482
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 163.54 % 10.95 36.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54141 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 104.28 % 7.07 23.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54047 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 127.74 mmHg 7.4 16.55 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14336 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 2 26.75 mmHg 4.15 5.87 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17252 381
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 0.0 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19796 381
SS-Chr 3BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 65.55 ml/min 4.83 16.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20818 381
SS-Chr 3BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 403.59 beats/min 17.14 41.98 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20927 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 43.24 ml/min 4.31 14.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18719 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 4 115.63 mmHg 6.73 13.47 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18879 381
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 6 199.17 U/l 29.69 72.72 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36440 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 32.05 g/dl 0.11 0.36 automated blood cell counting method Moms and pups used in studies were fed Teklad 37361 401
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 6 9.48 mg/dl 0.27 0.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36685 401
SS-Chr 3BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 10 9.64 mg/dl 0.08 0.26 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36786 401
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 30.86 ml/min 2.29 7.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20270 381
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 0.11 degrees C 0.25 0.86 digital rectal thermometry Moms and pups used in studies were fed Teklad 20366 381
SS-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 36.85 degrees C 0.32 1.01 digital rectal thermometry Moms and pups used in studies were fed Teklad 19131 381
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 6 844.83 s 29.58 72.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49354 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 9.24 % 1.05 3.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49457 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 9 11.09 % 2.64 7.92 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49758 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1134.3 s 50.23 158.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50287 461
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 7 59.33 fl 0.48 1.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 38806 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 64.4 U/l 6.88 21.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42450 401
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 6 109.5 mmol/l 0.92 2.26 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39178 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 6 144.5 mmol/l 1.09 2.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39449 401
SS-Chr 3BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.22 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42679 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 7 0.2 x 1000 cells/ul 0.05 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 39735 401
SS-Chr 3BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 13.8 mmol/l 0.49 1.55 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43164 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 17.64 pg 0.23 0.71 automated blood cell counting method Moms and pups used in studies were fed Teklad 40225 401
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 14 131.0 g 7.5 28.0 whole body digital scale Moms and pups used in studies were fed Teklad 59123 526
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 6 50.67 U/l 7.6 18.61 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40775 401
SS-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 7 23.43 mg/dl 1.25 3.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40884 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 7 5.56 x 1000 cells/ul 0.69 1.82 automated blood cell counting method Moms and pups used in studies were fed Teklad 40987 401
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 8 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59385 526
SS-Chr 3BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 10 1.74 g/dl 0.06 0.19 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41054 401
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59608 526
SS-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 16.96 g/dl 0.27 0.7 automated blood cell counting method Moms and pups used in studies were fed Teklad 38024 401
SS-Chr 3BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 92.9 mg/dl 2.7 8.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38466 401
SS-Chr 3BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 19.8 mg/dl 0.88 2.78 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41785 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 6 154.33 mg/dl 18.87 46.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38591 401
SS-Chr 3BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 10 55.2 fl 0.68 2.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 38674 401
SS-Chr 3BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 57.13 fl 0.53 1.68 automated blood cell counting method Moms and pups used in studies were fed Teklad 38680 401
SS-Chr 3BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1153.7 s 31.84 100.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46609 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 268.88 beats/min 13.6 40.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47642 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 26.21 % 6.91 20.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48582 461
SS-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 0.76 g/mg 0.1 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57352 522
SS-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 10 42.57 % 0.56 1.78 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57514 526
SS-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 29.07 ml/min 2.38 7.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16209 381
SS-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 0.92 g/mg 0.07 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55806 522
SS-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.1 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54698 522
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 19.78 ml/min/kg 2.29 6.05 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58656 526
SS-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.09 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54930 522
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 6 1.51 mg/kg 0.37 0.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58967 526
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 6.19 g/kg 0.33 1.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45640 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 88.16 mmHg 5.92 18.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45789 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 51.52 mmHg 6.59 16.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47757 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 8.48 ml/min/g 0.81 2.56 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46930 461
SS-Chr 3BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.7 g/kg 0.36 1.13 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47015 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 77.45 mmHg 8.59 21.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44871 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 47.3 % 2.58 7.3 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46121 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 52.46 % 3.95 11.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46126 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 6 27.83 mmHg 3.07 7.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48089 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 34.9 mmHg 3.33 10.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48094 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 5.29 ml/min/g 0.76 2.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46257 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 6.31 mmHg 0.25 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47257 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.44 IU/g 0.08 0.27 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47331 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 78.73 % 3.86 11.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48355 461
SS-Chr 3BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 7 1.04 mEq/d 0.11 0.3 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52950 482
SS-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 9 138.24 mg/d 24.67 74.0 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52600 482
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 156.18 % 8.71 28.9 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54275 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 131.71 % 6.41 22.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13737 381
SS-Chr 3BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 402.36 beats/min 12.37 27.65 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20933 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 123.77 % 9.64 31.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53814 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 113.73 % 4.34 15.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53941 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 109.67 % 6.85 22.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53946 381
SS-Chr 3BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.46 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20629 381
SS-Chr 3BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 11 180.7 g 3.7 12.3 whole body digital scale Moms and pups used in studies were fed Dyets 17879 381
SS-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 0.32 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18039 381
SS-Chr 3BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 168.19 breaths/min 11.61 36.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16973 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 120.99 breaths/min 8.33 28.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18322 381
SS-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 93.05 breaths/min 5.68 18.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18472 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 105.33 mmHg 6.94 13.87 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18873 381
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 6 5.27 g/dl 0.11 0.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37023 401
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 7 5.56 g/dl 0.13 0.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37018 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 7 76.71 mg/dl 3.68 9.74 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37153 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 31.95 g/dl 0.12 0.37 automated blood cell counting method Moms and pups used in studies were fed Teklad 37355 401
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 124.8 % 8.1 26.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18605 381
SS-Chr 3BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 142.2 mmol/l 0.49 1.55 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36523 401
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during 2-3 min hypercapnia/control during standard conditions 257.47 % 17.31 57.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19268 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 -41.7 mmHg 8.05 16.11 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19469 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 -58.5 mmHg 10.7 15.13 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19475 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 61.05 mmHg 2.85 4.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20487 381
SS-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 231.37 beats/min 14.3 40.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49001 461
SS-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 198.86 beats/min 15.19 45.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49006 461
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 932.6 s 36.18 114.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49359 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 8 14.38 % 3.08 8.72 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49452 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 8 20.92 % 5.35 15.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49753 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 34.5 mmHg 3.14 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50057 461
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 894.1 s 37.56 118.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50180 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1046.22 s 43.57 130.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50282 461
SS-Chr 3BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 10 0.52 x 1000 cells/ul 0.05 0.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 38923 401
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 6 20.17 mmol/l 1.11 2.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42123 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 6 3.77 g/dl 0.13 0.31 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42294 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 8.12 x 10E6 cells/ul 0.28 0.73 automated blood cell counting method Moms and pups used in studies were fed Teklad 39298 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 7 88.29 U/l 4.25 11.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42826 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 6 67.83 U/l 5.58 13.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42831 401
SS-Chr 3BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.15 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42916 401
SS-Chr 3BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 29.7 mmol/l 0.6 1.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43023 401
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 117.12 % 6.91 23.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54382 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 124.51 % 10.02 33.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54387 381
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 31.96 g/dl 0.21 0.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 39838 401
SS-Chr 3BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 10 6.6 x 1000 cells/ul 0.45 1.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 39912 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 7 0.78 x 1000 cells/ul 0.07 0.19 automated blood cell counting method Moms and pups used in studies were fed Teklad 43280 401
SS-Chr 3BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 102.7 mmol/l 0.54 1.7 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40039 401
SS-Chr 3BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 13.6 g/dl 0.18 0.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 40129 401
SS-Chr 3BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 10 4.15 mmol/l 0.09 0.3 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43354 401
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 176.64 % 18.52 58.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53695 381
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 8 0.72 mg/kg 0.19 0.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59197 526
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 6 11.27 mg/dl 0.7 1.72 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37655 401
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 10 50.0 U/l 3.01 9.51 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37734 401
SS-Chr 3BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 10 9.43 mg/dl 0.36 1.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37854 401
SS-Chr 3BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 9.69 mg/dl 0.29 0.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37860 401
SS-Chr 3BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 1.47 g/dl 0.05 0.16 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41060 401
SS-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 41.76 % 0.51 1.62 automated blood cell counting method Moms and pups used in studies were fed Teklad 41335 401
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.39 null 0.02 0.07 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59799 526
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 7 4.58 x 1000 cells/ul 0.68 1.79 automated blood cell counting method Moms and pups used in studies were fed Teklad 41564 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 6 19.0 mmol/l 1.84 4.52 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38322 401
SS-Chr 3BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 10 83.1 mg/dl 1.82 5.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38460 401
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 90.87 mmHg 7.51 23.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45565 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 56.19 mmHg 4.66 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46472 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 59.04 mmHg 4.3 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46477 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 7 1074.86 s 39.42 104.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46604 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 87.22 mmHg 4.06 12.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48679 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 7 16.25 IU/g 2.42 6.41 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 48874 461
SS-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.05 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55299 522
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 14.94 ml/min/kg 1.39 4.8 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57659 526
SS-Chr 3BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 9 224.0 g 11.9 35.8 whole body digital scale Moms and pups used in studies were fed Teklad 55432 522
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 11 19.73 ml/min/kg 1.38 4.59 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57856 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 13 0.24 null 0.01 0.03 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57928 526
SS-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 -7.08 null 0.08 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55643 522
SS-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 25.0 ml/min 1.5 4.97 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16752 381
SS-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.05 g/mg 0.08 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55812 522
SS-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 -7.21 null 0.13 0.38 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56123 522
SS-Chr 3BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 9 0.08 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54924 522
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 14 0.41 null 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58794 526
SS-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 1.53 E-7mole 0.22 0.66 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56544 522
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.33 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59805 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 10.61 ml/min/kg 0.92 2.6 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60021 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 11.69 ml/min/kg 1.54 4.09 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60027 526
SS-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -6.98 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56933 522
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 4 32.45 mmHg 2.26 4.53 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16079 381
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.39 g/kg 0.36 1.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45634 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 10.41 ml/min/g 1.05 2.96 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46708 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 9.12 ml/min/g 0.68 2.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46713 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 69.36 mmHg 5.56 13.63 balloon tipped catheter with pressure transducer in isolated perfused heart 46806 461
SS-Chr 3BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 132.4 g 6.4 20.1 whole body digital scale Moms and pups used in studies were fed Teklad 47837 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 18.62 IU/g 3.31 9.36 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45978 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 15.78 IU/g 1.02 3.22 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45983 461
SS-Chr 3BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 5.58 g/kg 0.38 1.14 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47009 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 25.93 mmHg 5.83 14.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47967 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 79.28 mmHg 9.58 28.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44876 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 103.99 % 11.21 27.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44974 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 88.25 % 1.92 5.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48350 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 88.03 % 4.05 11.44 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48462 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 30.01 mmHg 4.66 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45330 461
SS-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 96.43 breaths/min 4.49 14.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14992 381
SS-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 98.7 breaths/min 5.57 17.62 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14997 381
SS-Chr 3BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 441.68 beats/min 10.42 23.3 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15933 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15295 381
SS-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.29 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15459 381
SS-Chr 3BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 66.41 ml/min 4.03 13.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14557 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 11 111.3 breaths/min 5.55 18.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14856 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 5 175.0 mmHg 4.7 10.52 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52852 482
SS-Chr 3BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 5 1.84 ml/min 0.2 0.46 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52164 482
SS-Chr 3BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 7 95.55 mg/d 11.55 30.56 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52703 482
SS-Chr 3BN/Mcwi percentage of study population developing mammary tumors during a period of time 7,12-dimethyltetraphene (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152.0 days-162.0 days 14 29.0 % manual palpation method 0 DMBA oral gavage 105 days 200 mg DMBA in 10 ml seame oil 65566 86
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 255.61 % 21.59 71.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14255 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 140.79 mmHg 7.38 16.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14342 381
SS-Chr 3BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 158.92 breaths/min 6.83 21.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17173 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 131.38 % 6.78 22.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13742 381
SS-Chr 3BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 114.48 mmHg 5.52 9.57 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19877 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 107.12 % 5.25 18.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53809 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -5.0 mmHg 1.05 2.09 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19638 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 11 32.36 ml/min 2.01 6.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18724 381
SS-Chr 3BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 10 5.66 x 1000 cells/ul 0.4 1.27 automated blood cell counting method Moms and pups used in studies were fed Teklad 36896 401
SS-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.35 degrees C 0.21 0.7 digital rectal thermometry Moms and pups used in studies were fed Teklad 19126 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 115.88 % 4.44 15.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18600 381
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 406.64 beats/min 9.8 21.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17515 381
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 7 9.1 mg/dl 0.1 0.25 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36680 401
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 11 -0.15 degrees C 0.22 0.72 digital rectal thermometry Moms and pups used in studies were fed Teklad 20371 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 61.72 mmHg 1.84 4.51 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20481 381
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 89.04 mmHg 6.57 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49948 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 28.0 mmHg 1.77 5.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50052 461
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 7 58.47 fl 0.54 1.42 automated blood cell counting method Moms and pups used in studies were fed Teklad 38801 401
SS-Chr 3BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 10 0.37 x 1000 cells/ul 0.06 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 38929 401
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 7 21.57 mmol/l 1.17 3.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42118 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 7 52.26 % 0.74 1.95 automated blood cell counting method Moms and pups used in studies were fed Teklad 39047 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 7 3.86 g/dl 0.11 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42289 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 10 90.4 U/l 6.73 21.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42444 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 7 18.99 pg 0.26 0.69 automated blood cell counting method Moms and pups used in studies were fed Teklad 42601 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 18.96 pg 0.12 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 42606 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 7 144.0 mmol/l 0.58 1.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39444 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 7 0.31 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39632 401
SS-Chr 3BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 10 29.2 mmol/l 0.36 1.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43017 401
SS-Chr 3BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 10 15.6 mmol/l 0.37 1.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43158 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 7 0.76 x 1000 cells/ul 0.14 0.36 automated blood cell counting method Moms and pups used in studies were fed Teklad 43285 401
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 162.65 % 10.95 36.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54481 381
SS-Chr 3BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 3.91 mmol/l 0.12 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43360 401
SS-Chr 3BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 10 3.86 g/dl 0.05 0.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40434 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 6 1.5 g/dl 0.04 0.09 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40611 401
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 13 1.01 g/kg 0.04 0.14 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59481 526
SS-Chr 3BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 10 154.6 mg/dl 4.35 13.76 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41221 401
SS-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 42.57 % 0.56 1.78 automated blood cell counting method Moms and pups used in studies were fed Teklad 41329 401
SS-Chr 3BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 10 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41431 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 6 0.15 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41929 401
SS-Chr 3BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 7.72 x 10E6 cells/ul 0.12 0.37 automated blood cell counting method Moms and pups used in studies were fed Teklad 41996 401
SS-Chr 3BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 7.31 x 10E6 cells/ul 0.08 0.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 42002 401
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.62 g 0.04 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45460 461
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.75 g 0.04 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45465 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 32.48 % 4.75 14.24 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48587 461
SS-Chr 3BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.92 g/mg 0.13 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57358 522
SS-Chr 3BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 10 41.76 % 0.51 1.62 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57520 526
SS-Chr 3BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 169.6 g 3.4 10.8 whole body digital scale Moms and pups used in studies were fed Teklad 55438 522
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.36 degrees C 0.22 0.75 digital rectal thermometry Moms and pups used in studies were fed Teklad 16629 381
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 60.83 ml/min/kg 8.03 26.62 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58060 526
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.43 null 0.03 0.12 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58174 526
SS-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 32.33 ml/min 2.03 7.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16747 381
SS-Chr 3BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 184.2 g 4.4 13.9 whole body digital scale Moms and pups used in studies were fed Teklad 58371 526
SS-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 84.11 % 4.62 13.86 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54804 522
SS-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 1.21 E-7mole 0.21 0.67 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56538 522
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 11 1.2 mg/kg 0.21 0.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58962 526
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59921 526
SS-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 -6.85 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56939 522
SS-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 98.86 % 1.14 3.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57242 522
SS-Chr 3BN/Mcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.44 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17432 381
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 92.09 mmHg 3.83 11.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45784 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 88.06 mmHg 7.79 23.37 balloon tipped catheter with pressure transducer in isolated perfused heart 46811 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 55.22 % 6.66 18.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47132 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 48.99 % 3.5 11.07 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47137 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 36.43 % 6.01 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46375 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 33.5 % 6.33 17.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46380 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 228.17 beats/min 8.63 24.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45203 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 201.83 beats/min 12.42 39.26 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45208 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 22.73 mmHg 5.51 16.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45325 461
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 -0.17 degrees C 0.38 1.2 digital rectal thermometry Moms and pups used in studies were fed Teklad 15731 381
SS-Chr 3BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15454 381
SS-Chr 3BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 458.32 beats/min 23.26 40.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15939 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 9 175.29 mmHg 9.17 27.52 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52849 482
SS-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 8 0.42 ng/ml/h 0.07 0.2 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52455 482
SS-Chr 3BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 5 2.16 ng/ml/h 0.15 0.33 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52458 482
SS-Chr 3BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 7 55.99 mg/d 8.97 23.72 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52603 482
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 163.95 % 8.7 27.51 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54280 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 110.05 % 5.59 19.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54042 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 129.67 mmHg 6.23 13.92 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13490 381
SS-Chr 3BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.07 degrees C 0.2 0.66 digital rectal thermometry Moms and pups used in studies were fed Teklad 13616 381
SS-Chr 3BN/Mcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 36.68 degrees C 0.3 0.95 digital rectal thermometry Moms and pups used in studies were fed Teklad 13621 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 248.45 % 11.49 36.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14260 381
SS-Chr 3BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 148.94 breaths/min 7.18 23.81 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17168 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 6 29.25 mmHg 1.05 2.58 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17246 381
SS-Chr 3BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 123.13 mmHg 3.42 7.64 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19871 381
SS-Chr 3BN/Mcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 70.37 ml/min 3.53 11.17 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20823 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 -6.65 mmHg 1.05 1.48 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19644 381
SS-Chr 3BN/Mcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 150.89 breaths/min 4.81 15.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16968 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17054 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 7.52 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17060 381
SS-Chr 3BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 12 104.65 breaths/min 6.89 23.88 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18467 381
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 7 251.29 U/l 14.1 37.3 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36435 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 6 84.67 mg/dl 3.35 8.21 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37158 401
SS-Chr 3BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 10 5.6 g/dl 0.06 0.19 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37225 401
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 102.0 U/l 11.89 37.59 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37483 401
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 400.21 beats/min 26.78 59.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17509 381
SS-Chr 3BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 10 9.42 mg/dl 0.09 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36792 401
SS-Chr 3BN/Mcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 251.55 % 17.0 53.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19273 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 12 37.93 ml/min 3.4 11.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20265 381
SS-Chr 3BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.75 g 0.05 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49121 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 5.3 mmHg 0.21 0.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49238 461
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 117.1 g 6.8 21.5 whole body digital scale Moms and pups used in studies were fed Teklad 49536 461
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 122.4 g 5.6 17.6 whole body digital scale Moms and pups used in studies were fed Teklad 49542 461
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 7 48.07 % 1.54 4.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 39052 401
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 153.85 % 8.31 26.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54486 381
SS-Chr 3BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 13.4 g/dl 0.17 0.54 automated blood cell counting method Moms and pups used in studies were fed Teklad 40135 401
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 159.18 % 7.76 25.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53690 381
SS-Chr 3BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 10 0.39 x 1000 cells/ul 0.06 0.18 automated blood cell counting method Moms and pups used in studies were fed Teklad 40321 401
SS-Chr 3BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 10 0.13 x 1000 cells/ul 0.03 0.08 automated blood cell counting method Moms and pups used in studies were fed Teklad 40327 401
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 15 184.0 g 12.4 47.9 whole body digital scale Moms and pups used in studies were fed Teklad 59118 526
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 7 58.71 U/l 3.84 10.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40770 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 7 52.26 % 0.74 1.95 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59313 526
SS-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 6 30.67 mg/dl 2.47 6.06 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40889 401
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59391 526
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 35.4 U/l 3.59 11.35 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37740 401
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 14 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59603 526
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 12 1.45 g/kg 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59718 526
SS-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 7 15.39 g/dl 0.48 1.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 38029 401
SS-Chr 3BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 148.4 mg/dl 4.61 14.58 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41227 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 7 18.71 mmol/l 1.08 2.87 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38317 401
SS-Chr 3BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 10 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 41437 401
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 7 6.12 x 1000 cells/ul 0.44 1.15 automated blood cell counting method Moms and pups used in studies were fed Teklad 41559 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Teklad 41708 401
SS-Chr 3BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 10 16.5 mg/dl 0.78 2.46 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41779 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41924 401
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.39 IU/g 0.03 0.11 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47467 461
SS-Chr 3BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 26.4 ml/min 1.43 4.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16204 381
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 12 25.32 ml/min/kg 2.58 8.95 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57861 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.22 null 0.01 0.03 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57934 526
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 12 47.56 ml/min/kg 6.07 21.04 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58055 526
SS-Chr 3BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -7.13 null 0.08 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55649 522
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 10 0.47 null 0.04 0.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58169 526
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 45.31 ml/min/kg 5.18 14.64 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58253 526
SS-Chr 3BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.25 degrees C 0.12 0.43 digital rectal thermometry Moms and pups used in studies were fed Teklad 16869 381
SS-Chr 3BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.84 E-7mole 0.16 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55918 522
SS-Chr 3BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.08 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56129 522
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 14 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58545 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 17.07 ml/min/kg 1.65 4.67 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58650 526
SS-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 87.8 % 4.57 14.47 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54798 522
SS-Chr 3BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 90.75 % 3.82 10.79 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57248 522
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 51.46 mmHg 7.5 22.5 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47762 461
SS-Chr 3BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 9 116.1 g 3.7 11.0 whole body digital scale Moms and pups used in studies were fed Teklad 47831 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 8 11.06 ml/min/g 1.35 3.81 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46925 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 27.83 mmHg 5.78 17.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47972 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 4.3 ml/min/g 0.16 0.5 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44778 461
SS-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 262.72 beats/min 10.89 30.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48253 461
SS-Chr 3BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 271.35 beats/min 10.97 34.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48258 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 84.8 % 8.14 24.43 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44979 461