| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
75.0 days
| 5 |
14.4 |
um |
1.5 |
3.35 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
55 |
days |
|
|
108699 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 5 |
8.5 |
um |
0.7 |
1.57 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108718 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) |
Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. |
retinal photoreceptor layer morphology trait |
not specified |
56.0 days
| 15 |
0.0 |
um |
0.0 |
0.0 |
optical coherence tomography |
retina |
0.0 |
|
|
|
Heidelberg Spectralis SD-OCT |
|
110656 |
3181 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) |
Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. |
retinal photoreceptor layer morphology trait |
not specified |
70.0 days
| 12 |
0.0 |
um |
0.0 |
0.0 |
optical coherence tomography |
retina |
0.0 |
|
|
|
Heidelberg Spectralis SD-OCT |
|
110657 |
3181 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
51.0 days
| 5 |
27.7 |
um |
1.1 |
2.46 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
35 |
days |
pVAX2-rGDNF |
superior hemisphere |
108709 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
87.0 days
| 5 |
4.7 |
um |
0.7 |
1.57 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
71 |
days |
|
superior hemisphere |
108722 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) and sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
17.6 |
um |
1.7 |
3.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
54 |
days |
|
superior hemisphere |
108740 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) |
Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. |
retinal photoreceptor layer morphology trait |
not specified |
42.0 days
| 18 |
15.3 |
um |
0.7 |
2.97 |
optical coherence tomography |
retina |
0.0 |
|
|
|
Heidelberg Spectralis SD-OCT |
|
110655 |
3181 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
87.0 days
| 5 |
5.4 |
um |
0.6 |
1.34 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
71 |
days |
pVAX2-rGDNF |
superior hemisphere |
108721 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (15 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
16.8 |
um |
1.9 |
3.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108741 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) |
Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. |
retinal photoreceptor layer morphology trait |
not specified |
84.0 days
| 9 |
0.0 |
um |
0.0 |
0.0 |
optical coherence tomography |
retina |
0.0 |
|
|
|
Heidelberg Spectralis SD-OCT |
|
110658 |
3181 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
control condition |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
75.0 days
| 3 |
8.1 |
um |
1.2 |
2.08 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
|
55 |
days |
control for age matched plasmid injection |
|
108700 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
sham gene transfer using an empty plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
51.0 days
| 5 |
22.2 |
um |
0.9 |
2.01 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
35 |
days |
|
superior hemisphere |
108710 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 5 |
9.4 |
um |
1.0 |
2.24 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108717 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) and gene transfer of the rat GDNF gene using the plasmid vector pVAX2 (30 ug) |
Touchard E, et al., Gene Ther. 2012 Sep;19(9):886-98. doi: 10.1038/gt.2011.154. Epub 2011 Oct 13. |
retinal outer nuclear layer morphology trait |
both |
70.0 days
| 4 |
10.6 |
um |
1.7 |
3.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
|
0.0 |
plasmid delivery |
54 |
days |
pVAX2-rGDNF |
superior hemisphere |
108742 |
3131 |
| RCS-p+/LavRrrc |
retinal outer nuclear layer thickness |
light phase of controlled light/dark cycle (0-5 lux) (for 12 hours) |
Bubis E, et al., Transl Vis Sci Technol. 2019 Feb 28;8(1):26. doi: 10.1167/tvst.8.1.26. eCollection 2019 Jan. |
retinal photoreceptor layer morphology trait |
not specified |
28.0 days
| 21 |
50.5 |
um |
0.8 |
3.67 |
optical coherence tomography |
retina |
0.0 |
|
|
|
Heidelberg Spectralis SD-OCT |
|
110654 |
3181 |