Phenominer Database Results (167 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 121.4 % 7.59 25.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13671 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 30.63 mmHg 0.54 1.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17214 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 97.92 % 3.21 13.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53969 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.43 % 8.23 27.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53975 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 412.27 U/l 8.23 27.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36370 401
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.49 breaths/min 4.28 18.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14779 381
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 15.17 mmol/l 0.89 3.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42047 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.27 g/dl 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39768 401
FHH-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 4.89 x 1000 cells/ul 0.44 1.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40911 401
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 16.41 g/dl 0.18 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37953 401
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 4.08 x 1000 cells/ul 0.43 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41488 401
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 7.35 g/kg 0.2 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45590 461
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.78 ml/min/kg 3.48 10.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57990 526
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 36.58 degrees C 0.4 1.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16557 381
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.36 ml/min/g 0.47 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44709 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 7.27 g/kg 0.45 1.57 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45606 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 89.28 % 19.25 66.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48286 461
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 32.71 ml/min 2.41 7.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20199 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -6.89 mmHg 0.78 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19607 381
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 43.75 % 6.29 25.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47062 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 50.37 mmHg 5.31 19.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45255 461
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 24.09 mmol/l 0.67 2.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38252 401
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58480 526
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 56.97 fl 0.18 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38730 401
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 1.21 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45396 461
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 41.75 U/l 2.01 6.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40699 401
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 193.3 g 3.2 11.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59053 526
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59532 526
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 51.08 % 0.54 1.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38976 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38982 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 21.64 mg/dl 0.95 3.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40819 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 21.25 mg/dl 0.66 2.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40813 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 24.86 ml/min/kg 1.05 3.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57785 526
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 143.09 mmol/l 0.34 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39379 401
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 17 122.37 mmHg 3.52 14.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14302 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 107.2 % 7.1 23.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53874 381
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17032 381
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 286.33 U/l 7.3 25.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36364 401
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.75 mg/dl 0.09 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36609 401
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.71 mg/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36615 401
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 28.0 ml/min 0.84 3.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18647 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 33.51 ml/min 1.39 4.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18653 381
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 1139.92 s 62.15 215.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50218 461
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 12 169.2 g 6.0 20.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49508 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 891.13 s 79.07 306.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49284 461
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.93 x 10E6 cells/ul 0.12 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39228 401
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.11 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39659 401
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 114.12 % 3.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54315 381
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.12 g/dl 0.1 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39762 401
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 157.8 g 3.4 11.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59047 526
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 129.03 % 6.28 27.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53736 381
FHH-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.2 mg/dl 0.18 0.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37585 401
FHH-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 11 5.26 mmol/l 0.16 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38057 401
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.77 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59642 526
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.53 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59648 526
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41859 401
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 73.96 % 7.93 26.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48747 461
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.49 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58718 526
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.34 IU/g 0.03 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47438 461
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.49 mmHg 1.9 6.3 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20459 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 30.22 mmHg 0.8 2.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17226 381
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 207.48 beats/min 12.18 43.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45133 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 47.22 mmHg 8.01 25.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45261 461
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 4.4 x 1000 cells/ul 0.39 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41494 401
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41638 401
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 18 138.3 g 2.1 8.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49492 461
FHH-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 43.25 mmHg 3.84 13.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49988 461
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59248 526
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 8.97 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39222 401
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 143.58 mmol/l 0.26 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39373 401
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 81.45 mg/dl 2.51 8.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37088 401
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.58 breaths/min 4.82 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14785 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 %change=VE during 2-3 min hypoxia/control during standard conditions 134.35 % 5.92 25.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13665 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.06 breaths/min 5.06 16.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18256 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -46.38 mmHg 1.86 6.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19436 381
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 55.69 mmHg 1.25 4.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20447 381
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 106.78 mmHg 9.73 30.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49879 461
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 8.86 % 3.33 11.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49689 461
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 55.58 fl 0.18 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38736 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.28 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39567 401
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.93 mg/kg 0.35 1.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58891 526
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.1 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40541 401
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59538 526
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 150.18 mg/dl 6.18 20.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38521 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 16.94 ml/min/kg 0.59 2.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57583 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 13.9 ml/min/kg 0.58 1.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57589 526
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 82.98 % 8.82 30.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48741 461
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 45.28 ml/min/kg 1.36 4.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57984 526
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 10.71 ml/min/g 0.51 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46638 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 70.13 % 8.72 33.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48280 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.91 mmHg 0.14 0.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47182 461
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.05 mmHg 0.64 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19618 381
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 102.81 mmHg 5.11 19.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49873 461
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.18 mg/kg 0.48 1.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58897 526
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 16 9.38 % 3.21 12.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49683 461
FHH-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 5.58 x 1000 cells/ul 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40917 401
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13908 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19757 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.04 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19768 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 105.47 % 3.84 16.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53868 381
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 5.87 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36953 401
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 411.34 beats/min 11.45 37.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17487 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 -0.29 degrees C 0.12 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20294 381
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 13.64 mmol/l 0.51 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42053 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 18.31 pg 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42530 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.95 pg 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42536 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.26 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39561 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 12 82.08 U/l 2.68 9.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42755 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 91.82 U/l 3.43 11.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42761 401
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.02 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40535 401
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.8 g/dl 0.18 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37959 401
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58474 526
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 11 0.52 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58724 526
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 20.8 IU/g 5.77 12.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45949 461
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 115.85 % 6.55 21.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53742 381
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 16 0.29 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47422 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 59.57 mmHg 5.75 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46408 461
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 21.92 mmol/l 0.87 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38246 401
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.55 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58098 526
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.5 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58104 526
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41632 401
FHH-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 38.56 mmHg 2.77 11.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49982 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 262.5 beats/min 10.58 42.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47567 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 240.81 beats/min 10.48 36.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47573 461
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 43.85 % 11.32 25.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48512 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 111.93 mmHg 2.53 5.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48609 461
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 53.82 U/l 2.48 8.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40705 401
FHH-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.28 mg/dl 0.22 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37579 401
FHH-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 110.64 mmol/l 0.36 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39108 401
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 21.34 ml/min/kg 0.88 2.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57791 526
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15218 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15224 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13914 381
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 5.93 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36947 401
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17020 381
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 17 411.57 beats/min 13.0 53.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17475 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 26.0 ml/min 0.89 3.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20193 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.34 degrees C 0.11 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20300 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.69 breaths/min 4.07 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18250 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -46.57 mmHg 2.47 8.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19447 381
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 1196.63 s 65.49 261.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50212 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 909.5 s 58.4 202.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49290 461
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 3.91 g/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42218 401
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 127.71 % 3.97 17.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54309 381
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.22 x 1000 cells/ul 0.04 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39665 401
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 159.75 mg/dl 4.42 15.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38515 401
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 32.38 % 5.22 14.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48518 461
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41853 401
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.43 degrees C 0.21 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16563 381
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 5.93 ml/min/g 0.73 2.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44703 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 121.86 mmHg 4.68 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45714 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 259.58 beats/min 49.97 158.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45139 461
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 75.25 mg/dl 1.64 5.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37082 401
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 119.18 mmHg 4.58 15.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14314 381
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 30.85 % 5.02 17.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47068 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.91 mmHg 0.17 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47188 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 52.44 mmHg 3.49 13.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46402 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 143.49 mmHg 10.46 31.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45720 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 11.57 ml/min/g 0.41 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46644 461
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 1.01 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45390 461
FHH-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.67 x 1000 cells/ul 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43209 401
FHH-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.91 x 1000 cells/ul 0.11 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43215 401
FHH-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 111.08 mmol/l 0.26 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39102 401
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 140.05 mmHg 11.43 32.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48615 461
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 51.08 % 0.54 1.87 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59242 526
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.77 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42224 401
FHH-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.37 mmol/l 0.16 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38051 401