| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
48.9 |
um |
3.13 |
7.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105445 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (600 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
59.0 days-66.0 days |
5 |
38.6 |
um |
1.07 |
2.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105437 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (10 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
59.0 days-66.0 days |
5 |
40.8 |
um |
1.25 |
2.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105435 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
59.0 days-66.0 days |
5 |
41.0 |
um |
1.12 |
2.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105434 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
53.4 |
um |
2.33 |
5.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105442 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
55.6 |
um |
1.25 |
2.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105444 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
52.5 |
um |
2.33 |
5.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105443 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
51.1 |
um |
1.65 |
3.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105455 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
40.9 |
um |
2.15 |
4.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105457 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (100 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
59.0 days-66.0 days |
5 |
38.5 |
um |
1.07 |
2.4 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105436 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
49.2 |
um |
2.95 |
6.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105456 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
50.6 |
um |
1.61 |
3.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
outer nuc layer |
105454 |
3016 |