| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (100 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
125.4 |
um |
3.53 |
7.9 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105472 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
142.2 |
um |
2.68 |
6.0 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105466 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
131.6 |
um |
4.87 |
10.9 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105470 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (600 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
129.6 |
um |
4.2 |
9.4 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105473 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
132.4 |
um |
3.44 |
7.7 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105469 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
134.5 |
um |
3.35 |
7.5 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105468 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
140.0 |
um |
3.22 |
7.2 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105467 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
AMG-8718 (10 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
129.9 |
um |
3.71 |
8.3 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105471 |
3016 |